p38α MAP kinase as a sensor of reactive oxygen species in tumorigenesis I Dolado, A Swat, N Ajenjo, G De Vita, A Cuadrado, AR Nebreda Cancer cell 11 (2), 191-205, 2007 | 496 | 2007 |
Pim 1 kinase inhibitor ETP-45299 suppresses cellular proliferation and synergizes with PI3K inhibition C Blanco-Aparicio, AMG Collazo, J Oyarzabal, JF Leal, MI Albarán, ... Cancer letters 300 (2), 145-153, 2011 | 67 | 2011 |
Myc antagonizes Ras-mediated growth arrest in leukemia cells through the inhibition of the Ras-ERK-p21Cip1 pathway JP Vaqué, J Navascues, Y Shiio, M Laiho, N Ajenjo, I Mauleon, ... Journal of Biological Chemistry 280 (2), 1112-1122, 2005 | 55 | 2005 |
The Rho family GTPase Cdc42 regulates the activation of Ras/MAP kinase by the exchange factor Ras-GRF I Arozarena, DS Aaronson, D Matallanas, V Sanz, N Ajenjo, SP Tenbaum, ... Journal of Biological Chemistry 275 (34), 26441-26448, 2000 | 54 | 2000 |
Myeloid leukemia cell growth and differentiation are independent of mitogen-activated protein kinase ERK1/2 activation N Ajenjo, DS Aaronson, E Ceballos, C Richard, J León, P Crespo Journal of Biological Chemistry 275 (10), 7189-7197, 2000 | 48 | 2000 |
Regulation of c-Myc and Max in megakaryocytic and monocytic-macrophagic differentiation of K562 cells induced by protein kinase C modifiers: c-Myc is down-regulated but does … A Lerga, P Crespo, M Berciano, MD Delgado, M Canelles, C Cales, ... | 35 | 1999 |
Discovery of novel triazolo [4, 3-b] pyridazin-3-yl-quinoline derivatives as PIM inhibitors S Martinez-Gonzalez, S Rodriguez-Aristegui, CAG de la Oliva, ... European Journal of Medicinal Chemistry 168, 87-109, 2019 | 30 | 2019 |
A clinically compatible drug‐screening platform based on organotypic cultures identifies vulnerabilities to prevent and treat brain metastasis L Zhu, D Retana, P García‐Gómez, L Álvaro‐Espinosa, N Priego, ... EMBO Molecular Medicine 14 (3), e14552, 2022 | 12 | 2022 |
Macrocyclization as a source of desired polypharmacology. Discovery of triple PI3K/mTOR/PIM inhibitors S Martínez-González, RM Alvarez, JI Martín, AB García, ... ACS Medicinal Chemistry Letters 12 (11), 1794-1801, 2021 | 10 | 2021 |
Determination of viability of human cartilage allografts by a rapid and quantitative method not requiring cartilage digestion C López, N Ajenjo, MJ Muñoz-Alonso, P Farde, J León, J Gómez-Cimiano Cell Transplantation 17 (7), 859-864, 2008 | 10 | 2008 |
Machine learning identifies experimental brain metastasis subtypes based on their influence on neural circuits A Sanchez-Aguilera, M Masmudi-Martín, A Navas-Olive, P Baena, ... Cancer Cell 41 (9), 1637-1649. e11, 2023 | 6 | 2023 |
Public-Private Partnerships in Biobanking: Current Practices MM Morente, F de Luna, MC Marin, N Ajenjo Advances in Biobanking Practice through Public and Private Collaborations, 1-11, 2017 | 2 | 2017 |
Co-targeting PIM and PI3K/mTOR pathways with a single molecule: Novel orally available combined PIM/PI3K and PIM/PI3K/mTOR kinase inhibitors. C Blanco Aparicio, O Renner, E Gomez-Casero, A Cebria, N Ajenjo, ... MOLECULAR CANCER THERAPEUTICS 12 (11), 2013 | 2 | 2013 |
National biobank networking: the case of Spain MM Morente, F Luna-Crespo, N Ajenjo, MJ Artiga, E Ortega-Paino Biobanking of Human Biospecimens: Lessons from 25 Years of Biobanking …, 2021 | 1 | 2021 |
Abstract A275: Co-targeting PIM and PI3K/mTOR pathways with a single molecule: Novel orally available combined PIM/PI3K and PIM/PI3K/mTOR kinase inhibitors. C Blanco Aparicio, O Renner, E Gomez-Casero, A Cebriá, N Ajenjo, ... Molecular Cancer Therapeutics 12 (11_Supplement), A275-A275, 2013 | 1 | 2013 |
Abstract B228: Discovery of 6-Methyl-3-aryl-7, 8-dihydro-6H-9-oxa-1, 2, 3a, 4, 6-pentaaza-cyclopenta [a] naphthalen-5-ylamine compounds as Pim kinase inhibitors with potent … CB Aparicio, S Martinez, B Garcia-Serelde, AM Garcia-Collazo, N Ajenjo, ... Molecular Cancer Therapeutics 10 (11_Supplement), B228-B228, 2011 | | 2011 |
54 Biological characterization of ETP-45299, a selective small molecule inhibitor of PIM1, in human tumor cell lines CB Aparicio, AG Collazo, FR Lima, N Ajenjo, I Palacios, H Quiñones, ... Ejc Supplements 7 (8), 26, 2010 | | 2010 |
MOLECULAR BASIS OF CELL AND DEVELOPMENTAL BIOLOGY-Subcellular Localization Determines the Protective Effects of Activated ERK2 against Distinct Apoptogenic Stimuli in Myeloid … N Ajenjo, E Canon, I Sanchez-Perez, D Matallanas, J Leon, R Perona, ... Journal of Biological Chemistry 279 (31), 32813-32823, 2004 | | 2004 |
MOLECULAR BASIS OF CELL AND DEVELOPMENTAL BIOLOGY-Myeloid leukemia cell growth and differentiation are independent of mitogen-activated protein kinase ERK1/2 activation N Ajenjo, DS Aaronson, E Ceballos, C Richard, J Leon, P Crespo Journal of Biological Chemistry 275 (10), 7189-7197, 2000 | | 2000 |