| Type I interferon signals in macrophages and dendritic cells control dengue virus infection: implications for a new mouse model to test dengue vaccines R Züst, YX Toh, I Valdés, D Cerny, J Heinrich, L Hermida, E Marcos, ... Journal of virology 88 (13), 7276-7285, 2014 | 117 | 2014 |
| The ICL1 gene of Pichia pastoris, transcriptional regulation and use of its promoter J Menendez, I Valdes, N Cabrera Yeast 20 (13), 1097-1108, 2003 | 108 | 2003 |
| A novel fusion protein domain III-capsid from dengue-2, in a highly aggregated form, induces a functional immune response and protection in mice I Valdés, L Bernardo, L Gil, A Pavón, L Lazo, C López, Y Romero, ... Virology 394 (2), 249-258, 2009 | 85 | 2009 |
| The cellular immune response plays an important role in protecting against dengue virus in the mouse encephalitis model L Gil, C López, A Blanco, L Lazo, J Martín, I Valdés, Y Romero, ... Viral immunology 22 (1), 23-30, 2009 | 68 | 2009 |
| In vitro assembly of nucleocapsid-like particles from purified recombinant capsid protein of dengue-2 virus C López, L Gil, L Lazo, I Menéndez, E Marcos, J Sánchez, I Valdés, ... Archives of virology 154, 695-698, 2009 | 66 | 2009 |
| Amino acid changes in the recombinant Dengue 3 Envelope domain III determine its antigenicity and immunogenicity in mice A Zulueta, J Martín, L Hermida, M Alvarez, I Valdés, I Prado, G Chinea, ... Virus research 121 (1), 65-73, 2006 | 61 | 2006 |
| Immunological evaluation in nonhuman primates of formulations based on the chimeric protein P64k-domain III of dengue 2 and two components of Neisseria meningitidis I Valdés, L Hermida, J Martín, T Menéndez, L Gil, L Lazo, J Castro, ... Vaccine 27 (7), 995-1001, 2009 | 59 | 2009 |
| A fragment of the envelope protein from dengue‐1 virus, fused in two different sites of the meningococcal P64k protein carrier, induces a functional immune response in mice L Hermida, R Rodríguez, L Lazo, L Bernardo, R Silva, A Zulueta, C Lopez, ... Biotechnology and applied biochemistry 39 (1), 107-114, 2004 | 53 | 2004 |
| Recombinant nucleocapsid-like particles from dengue-2 virus induce protective CD4+ and CD8+ cells against viral encephalitis in mice L Gil, C Lopez, L Lazo, I Valdés, E Marcos, R Alonso, A Gambe, J Martín, ... International immunology 21 (10), 1175-1183, 2009 | 47 | 2009 |
| The protein DIIIC‐2, aggregated with a specific oligodeoxynucleotide and adjuvanted in alum, protects mice and monkeys against DENV‐2 L Gil, E Marcos, A Izquierdo, L Lazo, I Valdés, P Ambala, L Ochola, ... Immunology and cell biology 93 (1), 57-66, 2015 | 43 | 2015 |
| Dengue‐4 envelope domain III fused twice within the meningococcal P64k protein carrier induces partial protection in mice L Lazo, A Zulueta, L Hermida, A Blanco, J Sánchez, I Valdés, L Gil, ... Biotechnology and applied biochemistry 52 (4), 265-271, 2009 | 42 | 2009 |
| Generation and characterization of potential dengue vaccine candidates based on domain III of the envelope protein and the capsid protein of the four serotypes of dengue virus E Suzarte, E Marcos, L Gil, I Valdés, L Lazo, Y Ramos, Y Pérez, V Falcón, ... Archives of virology 159, 1629-1640, 2014 | 39 | 2014 |
| The fusion site of envelope fragments from each serotype of Dengue virus in the P64k protein, influence some parameters of the resulting chimeric constructs A Zulueta, L Hermida, L Lazo, I Valdés, R Rodrı́guez, C López, R Silva, ... Biochemical and biophysical research communications 308 (3), 619-626, 2003 | 39 | 2003 |
| Co-administration of tilapia alpha-helical antimicrobial peptides with subunit antigens boost immunogenicity in mice and tilapia (Oreochromis niloticus) J Acosta, Y Carpio, I Valdés, J Velázquez, Y Zamora, R Morales, ... Vaccine 32 (2), 223-229, 2014 | 35 | 2014 |
| Recombinant nucleocapsid-like particles from dengue-2 induce functional serotype-specific cell-mediated immunity in mice L Gil, L Bernardo, A Pavon, A Izquierdo, I Valdes, L Lazo, E Marcos, ... Journal of general virology 93 (6), 1204-1214, 2012 | 35 | 2012 |
| Nucleocapsid-like particles of dengue-2 virus enhance the immune response against a recombinant protein of dengue-4 virus L Lazo, L Gil, C Lopez, I Valdes, E Marcos, M Álvarez, A Blanco, ... Archives of virology 155, 1587-1595, 2010 | 35 | 2010 |
| The chimeric protein domain III-capsid of dengue virus serotype 2 (DEN-2) successfully boosts neutralizing antibodies generated in monkeys upon infection with DEN-2 I Valdés, L Gil, Y Romero, J Castro, P Puente, L Lazo, E Marcos, ... Clinical and Vaccine Immunology 18 (3), 455-459, 2011 | 34 | 2011 |
| A novel tetravalent formulation combining the four aggregated domain III-capsid proteins from dengue viruses induces a functional immune response in mice and monkeys E Suzarte, L Gil, I Valdés, E Marcos, L Lazo, A Izquierdo, A García, ... International immunology 27 (8), 367-379, 2015 | 33 | 2015 |
| A tetravalent formulation based on recombinant nucleocapsid-like particles from dengue viruses induces a functional immune response in mice and monkeys L Gil, K Cobas, L Lazo, E Marcos, L Hernández, E Suzarte, A Izquierdo, ... The Journal of Immunology 197 (9), 3597-3606, 2016 | 32 | 2016 |
| Heterologous prime-boost strategy in non-human primates combining the infective dengue virus and a recombinant protein in a formulation suitable for human use I Valdés, L Hermida, L Gil, L Lazo, J Castro, J Martín, L Bernardo, C López, ... International Journal of Infectious Diseases 14 (5), e377-e383, 2010 | 32 | 2010 |
