| Characterization of Genomic Deletion Efficiency Mediated by Clustered Regularly Interspaced Palindromic Repeats (CRISPR)/Cas9 Nuclease System in Mammalian Cells*♦ MC Canver, DE Bauer, A Dass, YY Yien, J Chung, T Masuda, T Maeda, ... Journal of Biological Chemistry 289 (31), 21312-21324, 2014 | 443 | 2014 |
| Restored iron transport by a small molecule promotes absorption and hemoglobinization in animals AS Grillo, AM SantaMaria, MD Kafina, AG Cioffi, NC Huston, M Han, ... Science 356 (6338), 608-616, 2017 | 144 | 2017 |
| Snx3 regulates recycling of the transferrin receptor and iron assimilation C Chen, D Garcia-Santos, Y Ishikawa, A Seguin, L Li, KH Fegan, ... Cell metabolism 17 (3), 343-352, 2013 | 130 | 2013 |
| Mitochondrial ClpX activates a key enzyme for heme biosynthesis and erythropoiesis JR Kardon, YY Yien, NC Huston, DS Branco, GJ Hildick-Smith, KY Rhee, ... Cell 161 (4), 858-867, 2015 | 116 | 2015 |
| EKLF/KLF1, a tissue-restricted integrator of transcriptional control, chromatin remodeling, and lineage determination YY Yien, JJ Bieker Molecular and cellular biology, 2013 | 85 | 2013 |
| Mutation in human CLPX elevates levels of δ-aminolevulinate synthase and protoporphyrin IX to promote erythropoietic protoporphyria YY Yien, S Ducamp, LN van der Vorm, JR Kardon, H Manceau, ... Proceedings of the National Academy of Sciences 114 (38), E8045-E8052, 2017 | 83 | 2017 |
| TMEM14C is required for erythroid mitochondrial heme metabolism YY Yien, RF Robledo, IJ Schultz, N Takahashi-Makise, B Gwynn, ... The Journal of clinical investigation 124 (10), 4294-4304, 2014 | 78 | 2014 |
| The mTORC1/4E-BP pathway coordinates hemoglobin production with L-leucine availability J Chung, DE Bauer, A Ghamari, CP Nizzi, KM Deck, PD Kingsley, YY Yien, ... Science signaling 8 (372), ra34-ra34, 2015 | 76 | 2015 |
| Macrocytic anemia and mitochondriopathy resulting from a defect in sideroflexin 4 GJ Hildick-Smith, JD Cooney, C Garone, LS Kremer, TB Haack, JN Thon, ... The American Journal of Human Genetics 93 (5), 906-914, 2013 | 68 | 2013 |
| Reductions in the mitochondrial ABC transporter Abcb10 affect the transcriptional profile of heme biosynthesis genes A Seguin, N Takahashi-Makise, YY Yien, NC Huston, JC Whitman, ... Journal of Biological Chemistry 292 (39), 16284-16299, 2017 | 41 | 2017 |
| FAM210B is an erythropoietin target and regulates erythroid heme synthesis by controlling mitochondrial iron import and ferrochelatase activity YY Yien, J Shi, C Chen, JTM Cheung, AS Grillo, R Shrestha, L Li, X Zhang, ... Journal of Biological Chemistry 293 (51), 19797-19811, 2018 | 40 | 2018 |
| Functional interactions between erythroid Kruppel-like factor (EKLF/KLF1) and protein phosphatase PPM1B/PP2Cβ YY Yien, JJ Bieker Journal of Biological Chemistry 287 (19), 15193-15204, 2012 | 27 | 2012 |
| The ubiquitous mitochondrial protein unfoldase CLPX regulates erythroid heme synthesis by control of iron utilization and heme synthesis enzyme activation and turnover CM Rondelli, M Perfetto, A Danoff, H Bergonia, S Gillis, L O'Neill, ... Journal of Biological Chemistry 297 (2), 2021 | 26 | 2021 |
| The RNA helicase DDX3 induces neural crest by promoting AKT activity M Perfetto, X Xu, C Lu, Y Shi, N Yousaf, J Li, YY Yien, S Wei Development 148 (2), dev184341, 2021 | 18 | 2021 |
| Regulation of heme synthesis by mitochondrial homeostasis proteins YY Yien, M Perfetto Frontiers in Cell and Developmental Biology 10, 895521, 2022 | 16 | 2022 |
| A mutation in the iron-responsive element of ALAS2 is a modifier of disease severity in a patient suffering from CLPX associated erythropoietic protoporphyria S Ducamp, S Luscieti, X Ferrer-Cortès, G Nicolas, H Manceau, K Peoc’h, ... Haematologica 106 (7), 2030, 2021 | 16 | 2021 |
| A role for iron deficiency in dopaminergic neurodegeneration YY Yien, BH Paw Proceedings of the National Academy of Sciences 113 (13), 3417-3418, 2016 | 15 | 2016 |
| Peristaltic pumps adapted for laminar flow experiments enhance in vitro modeling of vascular cell behavior J Abello, S Raghavan, YY Yien, AN Stratman Journal of Biological Chemistry 298 (10), 2022 | 12 | 2022 |
| Mitochondrial transport of protoporphyrinogen IX in erythroid cells YY Yien, AR Ringel, BH Paw Oncotarget 6 (25), 20742, 2015 | 11 | 2015 |
| Metalloprotease ADAM9 cleaves ephrin-B ligands and differentially regulates Wnt and mTOR signaling downstream of Akt kinase in colorectal cancer cells P Chandrasekera, M Perfetto, C Lu, M Zhuo, H Bahudhanapati, J Li, ... Journal of Biological Chemistry 298 (8), 2022 | 7 | 2022 |
