The FDA-approved drug ivermectin inhibits the replication of SARS-CoV-2 in vitro L Caly, JD Druce, MG Catton, DA Jans, KM Wagstaff Antiviral research 178, 104787, 2020 | 2702 | 2020 |
Ivermectin is a specific inhibitor of importin α/β-mediated nuclear import able to inhibit replication of HIV-1 and dengue virus KM Wagstaff, H Sivakumaran, SM Heaton, D Harrich, DA Jans Biochemical Journal 443 (3), 851-856, 2012 | 835 | 2012 |
Targeted delivery to the nucleus CW Pouton, KM Wagstaff, DM Roth, GW Moseley, DA Jans Advanced drug delivery reviews 59 (8), 698-717, 2007 | 304 | 2007 |
The Type III Effectors NleE and NleB from Enteropathogenic E. coli and OspZ from Shigella Block Nuclear Translocation of NF-κB p65 HJ Newton, JS Pearson, L Badea, M Kelly, M Lucas, G Holloway, ... PLoS pathogens 6 (5), e1000898, 2010 | 263 | 2010 |
Protein transduction: cell penetrating peptides and their therapeutic applications KM Wagstaff, DA Jans Current medicinal chemistry 13 (12), 1371-1387, 2006 | 241 | 2006 |
An AlphaScreen®-Based Assay for High-Throughput Screening for Specific Inhibitors of Nuclear Import KM Wagstaff, SM Rawlinson, AC Hearps, DA Jans Journal of biomolecular screening 16 (2), 192-200, 2011 | 215 | 2011 |
Importins and beyond: non‐conventional nuclear transport mechanisms KM Wagstaff, DA Jans Traffic 10 (9), 1188-1198, 2009 | 207 | 2009 |
Nuclear import and export inhibitors alter capsid protein distribution in mammalian cells and reduce Venezuelan Equine Encephalitis Virus replication L Lundberg, C Pinkham, A Baer, M Amaya, A Narayanan, KM Wagstaff, ... Antiviral research 100 (3), 662-672, 2013 | 205 | 2013 |
Ivermectin and COVID-19: a report in Antiviral Research, widespread interest, an FDA warning, two letters to the editor and the authors' responses M Bray, C Rayner, F Noël, D Jans, K Wagstaff Antiviral research 178, 104805, 2020 | 165 | 2020 |
Inhibitors of nuclear transport DA Jans, AJ Martin, KM Wagstaff Current opinion in cell biology 58, 50-60, 2019 | 152 | 2019 |
Nuclear trafficking of proteins from RNA viruses: potential target for antivirals? L Caly, KM Wagstaff, DA Jans Antiviral research 95 (3), 202-206, 2012 | 142 | 2012 |
Nuclear import of the respiratory syncytial virus matrix protein is mediated by importin β1 independent of importin α R Ghildyal, A Ho, KM Wagstaff, MM Dias, CL Barton, P Jans, P Bardin, ... Biochemistry 44 (38), 12887-12895, 2005 | 130 | 2005 |
A nuclear transport inhibitor that modulates the unfolded protein response and provides in vivo protection against lethal dengue virus infection JE Fraser, S Watanabe, C Wang, WKK Chan, B Maher, A Lopez-Denman, ... The Journal of infectious diseases 210 (11), 1780-1791, 2014 | 102 | 2014 |
Nucleocytoplasmic transport of DNA: enhancing non-viral gene transfer KM Wagstaff, DA Jans Biochemical Journal 406 (2), 185-202, 2007 | 96 | 2007 |
Histone-mediated transduction as an efficient means for gene delivery KM Wagstaff, DJ Glover, DJ Tremethick, DA Jans Molecular Therapy 15 (4), 721-731, 2007 | 88 | 2007 |
Ivermectin as a broad-spectrum host-directed antiviral: the real deal? DA Jans, KM Wagstaff Cells 9 (9), 2100, 2020 | 85 | 2020 |
Nuclear drug delivery to target tumour cells KM Wagstaff, DA Jans European journal of pharmacology 625 (1-3), 174-180, 2009 | 74 | 2009 |
Intramolecular masking of nuclear localization signals: analysis of importin binding using a novel AlphaScreen-based method KM Wagstaff, DA Jans Analytical biochemistry 348 (1), 49-56, 2006 | 72 | 2006 |
Global enhancement of nuclear localization‐dependent nuclear transport in transformed cells HV Kuusisto, KM Wagstaff, G Alvisi, DM Roth, DA Jans The FASEB Journal 26 (3), 1181-1193, 2012 | 70 | 2012 |
Fatty acid-binding proteins 1 and 2 differentially modulate the activation of peroxisome proliferator-activated receptor α in a ligand-selective manner MLR Hughes, B Liu, ML Halls, KM Wagstaff, R Patil, T Velkov, DA Jans, ... Journal of Biological Chemistry 290 (22), 13895-13906, 2015 | 68 | 2015 |