| ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex JH Lee, TT Paull Science 308 (5721), 551-554, 2005 | 1865 | 2005 |
| Direct activation of the ATM protein kinase by the Mre11/Rad50/Nbs1 complex JH Lee, TT Paull Science 304 (5667), 93-96, 2004 | 954 | 2004 |
| Activation and regulation of ATM kinase activity in response to DNA double-strand breaks JH Lee, TT Paull Oncogene 26 (56), 7741-7748, 2007 | 686 | 2007 |
| A forward chemical genetic screen reveals an inhibitor of the Mre11–Rad50–Nbs1 complex A Dupré, L Boyer-Chatenet, RM Sattler, AP Modi, JH Lee, ML Nicolette, ... Nature chemical biology 4 (2), 119-125, 2008 | 445 | 2008 |
| ATM functions at the peroxisome to induce pexophagy in response to ROS J Zhang, DN Tripathi, J Jing, A Alexander, J Kim, RT Powell, R Dere, ... Nature cell biology 17 (10), 1259-1269, 2015 | 411 | 2015 |
| The Mre11/Rad50/Nbs1 complex and its role as a DNA double-strand break sensor for ATM TT Paull, JH Lee Cell cycle 4 (6), 737-740, 2005 | 249 | 2005 |
| Catalytic and noncatalytic roles of the CtIP endonuclease in double-strand break end resection N Makharashvili, AT Tubbs, SH Yang, H Wang, O Barton, Y Zhou, ... Molecular cell 54 (6), 1022-1033, 2014 | 213 | 2014 |
| 53BP1 promotes ATM activity through direct interactions with the MRN complex JH Lee, AA Goodarzi, PA Jeggo, TT Paull The EMBO journal 29 (3), 574-585, 2010 | 179 | 2010 |
| Nbs1 converts the human Mre11/Rad50 nuclease complex into an endo/exonuclease machine specific for protein-DNA adducts RA Deshpande, JH Lee, S Arora, TT Paull Molecular cell 64 (3), 593-606, 2016 | 178 | 2016 |
| Cellular functions of the protein kinase ATM and their relevance to human disease JH Lee, TT Paull Nature Reviews Molecular Cell Biology 22 (12), 796-814, 2021 | 168 | 2021 |
| Hyperthermia activates a subset of ataxia-telangiectasia mutated effectors independent of DNA strand breaks and heat shock protein 70 status CR Hunt, RK Pandita, A Laszlo, R Higashikubo, M Agarwal, T Kitamura, ... Cancer research 67 (7), 3010-3017, 2007 | 163 | 2007 |
| ATP‐driven Rad50 conformations regulate DNA tethering, end resection, and ATM checkpoint signaling RA Deshpande, GJ Williams, O Limbo, RS Williams, J Kuhnlein, JH Lee, ... The EMBO journal 33 (5), 482-500, 2014 | 160 | 2014 |
| Rad50 adenylate kinase activity regulates DNA tethering by Mre11/Rad50 complexes V Bhaskara, A Dupré, B Lengsfeld, BB Hopkins, A Chan, JH Lee, X Zhang, ... Molecular cell 25 (5), 647-661, 2007 | 140 | 2007 |
| Regulation of the DNA damage response by DNA-PKcs inhibitory phosphorylation of ATM Y Zhou, JH Lee, W Jiang, JL Crowe, S Zha, TT Paull Molecular cell 65 (1), 91-104, 2017 | 139 | 2017 |
| Regulation of Mre11/Rad50 by Nbs1: effects on nucleotide-dependent DNA binding and association with ataxia-telangiectasia-like disorder mutant complexes JH Lee, R Ghirlando, V Bhaskara, MR Hoffmeyer, J Gu, TT Paull Journal of Biological Chemistry 278 (46), 45171-45181, 2003 | 138 | 2003 |
| Ataxia telangiectasia-mutated (ATM) kinase activity is regulated by ATP-driven conformational changes in the Mre11/Rad50/Nbs1 (MRN) complex JH Lee, MR Mand, RA Deshpande, E Kinoshita, SH Yang, C Wyman, ... Journal of Biological Chemistry 288 (18), 12840-12851, 2013 | 130 | 2013 |
| Multiple autophosphorylation sites are dispensable for murine ATM activation in vivo JA Daniel, M Pellegrini, JH Lee, TT Paull, L Feigenbaum, A Nussenzweig The Journal of cell biology 183 (5), 777-783, 2008 | 126 | 2008 |
| ATM directs DNA damage responses and proteostasis via genetically separable pathways JH Lee, MR Mand, CH Kao, Y Zhou, SW Ryu, AL Richards, JJ Coon, ... Science signaling 11 (512), eaan5598, 2018 | 106 | 2018 |
| ATM protein-dependent phosphorylation of Rad50 protein regulates DNA repair and cell cycle control M Gatei, B Jakob, P Chen, AW Kijas, OJ Becherel, N Gueven, G Birrell, ... Journal of Biological Chemistry 286 (36), 31542-31556, 2011 | 101 | 2011 |
| Mitochondrial redox sensing by the kinase ATM maintains cellular antioxidant capacity Y Zhang, JH Lee, TT Paull, S Gehrke, A D’alessandro, Q Dou, ... Science signaling 11 (538), eaaq0702, 2018 | 95 | 2018 |
