Combination therapy with histone deacetylase inhibitors (HDACi) for the treatment of cancer: achieving the full therapeutic potential of HDACi A Suraweera, KJ O’Byrne, DJ Richard Frontiers in oncology 8, 92, 2018 | 651 | 2018 |
PARP inhibitors: clinical relevance, mechanisms of action and tumor resistance M Rose, JT Burgess, K O’Byrne, DJ Richard, E Bolderson Frontiers in cell and developmental biology 8, 564601, 2020 | 450 | 2020 |
Generation and characterisation of cisplatin-resistant non-small cell lung cancer cell lines displaying a stem-like signature MP Barr, SG Gray, AC Hoffmann, RA Hilger, J Thomale, JD O’Flaherty, ... PloS one 8 (1), e54193, 2013 | 314 | 2013 |
Functions and therapeutic roles of exosomes in cancer JA Tickner, AJ Urquhart, SA Stephenson, DJ Richard, KJ O’Byrne Frontiers in oncology 4, 127, 2014 | 287 | 2014 |
Single-stranded DNA-binding protein hSSB1 is critical for genomic stability DJ Richard, E Bolderson, L Cubeddu, RIM Wadsworth, K Savage, ... Nature 453 (7195), 677-681, 2008 | 282 | 2008 |
Nucleophosmin: from structure and function to disease development JK Box, N Paquet, MN Adams, D Boucher, E Bolderson, KJ O’Byrne, ... BMC molecular biology 17, 1-12, 2016 | 263 | 2016 |
Recent advances in cancer therapy targeting proteins involved in DNA double-strand break repair E Bolderson, DJ Richard, BBS Zhou, KK Khanna Clinical Cancer Research 15 (20), 6314-6320, 2009 | 251 | 2009 |
Phosphorylation of Exo1 modulates homologous recombination repair of DNA double-strand breaks E Bolderson, N Tomimatsu, DJ Richard, D Boucher, R Kumar, TK Pandita, ... Nucleic acids research 38 (6), 1821-1831, 2010 | 225 | 2010 |
Circulating tumour cells, their role in metastasis and their clinical utility in lung cancer JD O’Flaherty, S Gray, JJ O’Leary, FH Blackhall, KJ O’Byrne Lung Cancer, 2011 | 211 | 2011 |
Identification of a BRCA1-mRNA splicing complex required for efficient DNA repair and maintenance of genomic stability KI Savage, JJ Gorski, EM Barros, GW Irwin, L Manti, AJ Powell, ... Molecular cell 54 (3), 445-459, 2014 | 198 | 2014 |
The role of DNA repair pathways in cisplatin resistant lung cancer S O’Grady, SP Finn, S Cuffe, DJ Richard, KJ O’Byrne, MP Barr Cancer treatment reviews 40 (10), 1161-1170, 2014 | 157 | 2014 |
The cancer stem-cell hypothesis: its emerging role in lung cancer biology and its relevance for future therapy JD O’Flaherty, M Barr, D Fennell, D Richard, J Reynolds, J O’Leary, ... Journal of thoracic oncology 7 (12), 1880-1890, 2012 | 155 | 2012 |
BRCA1 deficiency exacerbates estrogen-induced DNA damage and genomic instability KI Savage, KB Matchett, EM Barros, KM Cooper, GW Irwin, JJ Gorski, ... Cancer research 74 (10), 2773-2784, 2014 | 149 | 2014 |
Transcriptional regulation in response to oxygen and nitrate of the operons encoding the [NiFe] hydrogenases 1 and 2 of Escherichia coli DJ Richard, G Sawers, F Sargent, L McWalter, DH Boxer Microbiology 145 (10), 2903-2912, 1999 | 139 | 1999 |
Chemotherapeutic compounds targeting the DNA double-strand break repair pathways: the good, the bad, and the promising C Jekimovs, E Bolderson, A Suraweera, M Adams, KJ O’Byrne, ... Frontiers in oncology 4, 86, 2014 | 138 | 2014 |
Drug discovery approaches utilizing three-dimensional cell culture SL Ryan, AM Baird, G Vaz, AJ Urquhart, hias Senge, DJ Richard, ... Assay and drug development technologies 14 (1), 19-28, 2016 | 131 | 2016 |
HSSB1 and hSSB2 form similar multiprotein complexes that participate in DNA damage response Y Li, E Bolderson, R Kumar, PA Muniandy, Y Xue, DJ Richard, ... Journal of biological chemistry 284 (35), 23525-23531, 2009 | 128 | 2009 |
Multiple human single-stranded DNA binding proteins function in genome maintenance: structural, biochemical and functional analysis DJ Richard, E Bolderson, KK Khanna Critical reviews in biochemistry and molecular biology 44 (2-3), 98-116, 2009 | 122 | 2009 |
Par4 is a coactivator for a splice isoform–specific transcriptional activation domain in WT1 DJ Richard, V Schumacher, B Royer-Pokora, SGE Roberts Genes & development 15 (3), 328-339, 2001 | 122 | 2001 |
Human single-stranded DNA binding proteins are essential for maintaining genomic stability NW Ashton, E Bolderson, L Cubeddu, KJ O’Byrne, DJ Richard BMC molecular biology 14, 1-20, 2013 | 119 | 2013 |