| Targeting hypoxia in cancer therapy WR Wilson, MP Hay Nature Reviews Cancer 11 (6), 393-410, 2011 | 3323 | 2011 |
| Targeting GLUT1 and the Warburg effect in renal cell carcinoma by chemical synthetic lethality DA Chan, PD Sutphin, P Nguyen, S Turcotte, EW Lai, A Banh, ... Science translational medicine 3 (94), 94ra70-94ra70, 2011 | 584 | 2011 |
| A molecule targeting VHL-deficient renal cell carcinoma that induces autophagy S Turcotte, DA Chan, PD Sutphin, MP Hay, WA Denny, AJ Giaccia Cancer cell 14 (1), 90-102, 2008 | 292 | 2008 |
| Use of three-dimensional tissue cultures to model extravascular transport and predict in vivo activity of hypoxia-targeted anticancer drugs KO Hicks, FB Pruijn, TW Secomb, MP Hay, R Hsu, JM Brown, WA Denny, ... Journal of the National Cancer Institute 98 (16), 1118-1128, 2006 | 175 | 2006 |
| Recent developments in the design of bioreductive drugs. WA Denny, WR Wilson, MP Hay The British journal of cancer. Supplement 27, S32, 1996 | 142 | 1996 |
| Structure− activity relationships of 1, 2, 4-benzotriazine 1, 4-dioxides as hypoxia-selective analogues of tirapazamine MP Hay, SA Gamage, MS Kovacs, FB Pruijn, RF Anderson, AV Patterson, ... Journal of medicinal chemistry 46 (1), 169-182, 2003 | 139 | 2003 |
| Pharmacokinetic/pharmacodynamic modeling identifies SN30000 and SN29751 as tirapazamine analogues with improved tissue penetration and hypoxic cell killing in tumors KO Hicks, BG Siim, JK Jaiswal, FB Pruijn, AM Fraser, R Patel, A Hogg, ... Clinical Cancer Research 16 (20), 4946-4957, 2010 | 138 | 2010 |
| Targeting growth hormone function: strategies and therapeutic applications M Lu, JU Flanagan, RJ Langley, MP Hay, JK Perry Signal transduction and targeted therapy 4 (1), 3, 2019 | 131 | 2019 |
| Activation of 3-amino-1, 2, 4-benzotriazine 1, 4-dioxide antitumor agents to oxidizing species following their one-electron reduction RF Anderson, SS Shinde, MP Hay, SA Gamage, WA Denny Journal of the American Chemical Society 125 (3), 748-756, 2003 | 131 | 2003 |
| DNA-targeted 1, 2, 4-benzotriazine 1, 4-dioxides: potent analogues of the hypoxia-selective cytotoxin tirapazamine MP Hay, FB Pruijn, SA Gamage, HDS Liyanage, MS Kovacs, ... Journal of medicinal chemistry 47 (2), 475-488, 2004 | 102 | 2004 |
| Hypoxia-selective antitumor agents. 8. Bis (nitroimidazolyl) alkanecarboxamides: a new class of hypoxia-selective cytotoxins and hypoxic cell radiosensitizers MP Hay, WR Wilson, JW Moselen, BD Palmer, WA Denny Journal of medicinal chemistry 37 (3), 381-391, 1994 | 102 | 1994 |
| Chemical space mimicry for drug discovery W Yuan, D Jiang, DK Nambiar, LP Liew, MP Hay, J Bloomstein, P Lu, ... Journal of chemical information and modeling 57 (4), 875-882, 2017 | 97 | 2017 |
| Tricyclic [1, 2, 4] triazine 1, 4-dioxides as hypoxia selective cytotoxins MP Hay, KO Hicks, K Pchalek, HH Lee, A Blaser, FB Pruijn, RF Anderson, ... Journal of medicinal chemistry 51 (21), 6853-6865, 2008 | 96 | 2008 |
| Synthesis and evaluation of nitroheterocyclic carbamate prodrugs for use with nitroreductase-mediated gene-directed enzyme prodrug therapy MP Hay, RF Anderson, DM Ferry, WR Wilson, WA Denny Journal of medicinal chemistry 46 (25), 5533-5545, 2003 | 95 | 2003 |
| A 2-nitroimidazole carbamate prodrug of 5-amino-1-(chloromethyl)-3-[(5, 6, 7-trimethoxyindol-2-yl) carbonyl]-1, 2-dihydro-3H-benz [e] indole (amino-seco-CBI-TMI) for use with … MP Hay, BM Sykes, WA Denny, WR Wilson Bioorganic & medicinal chemistry letters 9 (15), 2237-2242, 1999 | 86 | 1999 |
| 4-Pyridylanilinothiazoles that selectively target von Hippel− Lindau deficient renal cell carcinoma cells by inducing autophagic cell death MP Hay, S Turcotte, JU Flanagan, M Bonnet, DA Chan, PD Sutphin, ... Journal of medicinal chemistry 53 (2), 787-797, 2010 | 85 | 2010 |
| Selective reaction of glycine residues in hydrogen atom transfer from amino acid derivatives VA Burgess, CJ Easton, MP Hay Journal of the American Chemical Society 111 (3), 1047-1052, 1989 | 80 | 1989 |
| The 2-nitroimidazole EF5 is a biomarker for oxidoreductases that activate the bioreductive prodrug CEN-209 under hypoxia J Wang, A Foehrenbacher, J Su, R Patel, MP Hay, KO Hicks, WR Wilson Clinical Cancer Research 18 (6), 1684-1695, 2012 | 72 | 2012 |
| Spin Trapping of Radicals Other Than the •OH Radical upon Reduction of the Anticancer Agent Tirapazamine by Cytochrome P450 Reductase SS Shinde, MP Hay, AV Patterson, WA Denny, RF Anderson Journal of the American Chemical Society 131 (40), 14220-14221, 2009 | 72 | 2009 |
| Extravascular transport of drugs in tumor tissue: effect of lipophilicity on diffusion of tirapazamine analogues in multicellular layer cultures FB Pruijn, JR Sturman, HDS Liyanage, KO Hicks, MP Hay, WR Wilson Journal of medicinal chemistry 48 (4), 1079-1087, 2005 | 69 | 2005 |
