关注
Claudio Zambaldo
Claudio Zambaldo
Scientist, Hoffmann-La Roche
在 roche.com 的电子邮件经过验证
标题
引用次数
引用次数
年份
A metabolite-derived protein modification integrates glycolysis with KEAP1–NRF2 signalling
MJ Bollong, G Lee, JS Coukos, H Yun, C Zambaldo, JW Chang, EN Chin, ...
Nature 562 (7728), 600-604, 2018
2402018
Genetically encoding phosphotyrosine and its nonhydrolyzable analog in bacteria
X Luo, G Fu, RE Wang, X Zhu, C Zambaldo, R Liu, T Liu, X Lyu, J Du, ...
Nature chemical biology 13 (8), 845-849, 2017
1282017
PNA-encoded chemical libraries
C Zambaldo, S Barluenga, N Winssinger
Current opinion in chemical biology 26, 8-15, 2015
912015
DNA display of fragment pairs as a tool for the discovery of novel biologically active small molecules
JP Daguer, C Zambaldo, M Ciobanu, P Morieux, S Barluenga, ...
Chemical science 6 (1), 739-744, 2015
832015
Small molecule-mediated inhibition of myofibroblast transdifferentiation for the treatment of fibrosis
MJ Bollong, B Yang, N Vergani, BA Beyer, EN Chin, C Zambaldo, D Wang, ...
Proceedings of the National Academy of Sciences 114 (18), 4679-4684, 2017
762017
Expanding the Scope of PNA‐Encoded Synthesis (PES): Mtt‐Protected PNA Fully Orthogonal to Fmoc Chemistry and a Broad Array of Robust Diversity‐Generating Reactions
D Chouikhi, M Ciobanu, C Zambaldo, V Duplan, S Barluenga, ...
Chemistry–A European Journal 18 (40), 12698-12704, 2012
752012
2-Sulfonylpyridines as tunable, cysteine-reactive electrophiles
C Zambaldo, EV Vinogradova, X Qi, J Iaconelli, RM Suciu, M Koh, ...
Journal of the American Chemical Society 142 (19), 8972-8979, 2020
742020
Recombinant thiopeptides containing noncanonical amino acids
X Luo, C Zambaldo, T Liu, Y Zhang, W Xuan, C Wang, SA Reed, PY Yang, ...
Proceedings of the National Academy of Sciences 113 (13), 3615-3620, 2016
682016
Screening for covalent inhibitors using DNA-display of small molecule libraries functionalized with cysteine reactive moieties
C Zambaldo, JP Daguer, J Saarbach, S Barluenga, N Winssinger
MedChemComm 7 (7), 1340-1351, 2016
642016
Identification of covalent bromodomain binders through DNA display of small molecules
JP Daguer, C Zambaldo, D Abegg, S Barluenga, C Tallant, S Müller, ...
Angewandte Chemie International Edition 54 (20), 6057-6061, 2015
612015
Targeted delivery of an anti-inflammatory PDE4 inhibitor to immune cells via an antibody–drug conjugate
S Yu, AD Pearson, RKV Lim, DT Rodgers, S Li, HB Parker, M Weglarz, ...
Molecular Therapy 24 (12), 2078-2089, 2016
522016
Recombinant macrocyclic lanthipeptides incorporating non-canonical amino acids
C Zambaldo, X Luo, AP Mehta, PG Schultz
Journal of the american chemical society 139 (34), 11646-11649, 2017
442017
Novel PTP1B inhibitors identified by DNA display of fragment pairs
S Barluenga, C Zambaldo, HA Ioannidou, M Ciobanu, P Morieux, ...
Bioorganic & medicinal chemistry letters 26 (3), 1080-1085, 2016
402016
YAP-dependent proliferation by a small molecule targeting annexin A2
SZ Shalhout, PY Yang, EM Grzelak, K Nutsch, S Shao, C Zambaldo, ...
Nature Chemical Biology 17 (7), 767-775, 2021
302021
Asymmetric synthesis of pochonin E and F, revision of their proposed structure, and their conversion to potent Hsp90 inhibitors
G Karthikeyan, C Zambaldo, S Barluenga, V Zoete, M Karplus, ...
Chemistry–A European Journal 18 (29), 8978-8986, 2012
302012
Selective affinity-based probe for oncogenic kinases suitable for live cell imaging
C Zambaldo, KK Sadhu, G Karthikeyan, S Barluenga, JP Daguer, ...
Chemical Science 4 (5), 2088-2092, 2013
272013
High-throughput solid-phase building block synthesis for DNA-encoded libraries
C Zambaldo, SN Geigle, AL Satz
Organic letters 21 (23), 9353-9357, 2019
152019
An orthogonal seryl-tRNA synthetase/tRNA pair for noncanonical amino acid mutagenesis in Escherichia coli
C Zambaldo, M Koh, F Nasertorabi, GW Han, A Chatterjee, RC Stevens, ...
Bioorganic & medicinal chemistry 28 (20), 115662, 2020
132020
Facile access to modified and functionalized PNAs through Ugi-based solid phase oligomerization
J Saarbach, D Masi, C Zambaldo, N Winssinger
Bioorganic & medicinal chemistry 25 (19), 5171-5177, 2017
132017
Identifizierung von niedermolekularen kovalenten Bromodomäne‐Bindern aus einer DNA‐kodierten Bibliothek
JP Daguer, C Zambaldo, D Abegg, S Barluenga, C Tallant, S Müller, ...
Angewandte Chemie 127 (20), 6155-6159, 2015
72015
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