Intravenous delivery of oncolytic reovirus to brain tumor patients immunologically primes for subsequent checkpoint blockade A Samson, KJ Scott, D Taggart, EJ West, E Wilson, GJ Nuovo, S Thomson, ... Science translational medicine 10 (422), eaam7577, 2018 | 372 | 2018 |
The autophagic tumor stroma model of cancer: Role of oxidative stress and ketone production in fueling tumor cell metabolism S Pavlides, A Tsirigos, G Migneco, D Whitaker-Menezes, B Chiavarina, ... Cell cycle 9 (17), 3485-3505, 2010 | 284 | 2010 |
Tumor cells induce the cancer associated fibroblast phenotype via caveolin-1 degradation: implications for breast cancer and DCIS therapy with autophagy inhibitors UE Martinez-Outschoorn, S Pavlides, D Whitaker-Menezes, KM Daumer, ... Cell Cycle 9 (12), 2423-2433, 2010 | 270 | 2010 |
HIF1-alpha functions as a tumor promoter in cancer-associated fibroblasts, and as a tumor suppressor in breast cancer cells: autophagy drives compartment-specific oncogenesis B Chiavarina, D Whitaker-Menezes, G Migneco, UE Martinez-Outschoorn, ... Cell cycle 9 (17), 3534-3551, 2010 | 266 | 2010 |
The reverse Warburg effect: glycolysis inhibitors prevent the tumor promoting effects of caveolin-1 deficient cancer associated fibroblasts G Bonuccelli, D Whitaker-Menezes, R Castello-Cros, S Pavlides, ... Cell cycle 9 (10), 1960-1971, 2010 | 258 | 2010 |
The autophagic tumor stroma model of cancer or “battery-operated tumor growth” a simple solution to the autophagy paradox UE Martinez-Outschoorn, D Whitaker-Menezes, S Pavlides, B Chiavarina, ... Cell cycle 9 (21), 4297-4306, 2010 | 189 | 2010 |
Glycolytic cancer associated fibroblasts promote breast cancer tumor growth, without a measurable increase in angiogenesis: evidence for stromal-epithelial metabolic coupling G Migneco, D Whitaker-Menezes, B Chiavarina, R Castello-Cros, ... Cell cycle 9 (12), 2412-2422, 2010 | 167 | 2010 |
Potentiating oncolytic virus-induced immune-mediated tumor cell killing using histone deacetylase inhibition VA Jennings, GB Scott, AMS Rose, KJ Scott, G Migneco, B Keller, K Reilly, ... Molecular Therapy 27 (6), 1139-1152, 2019 | 53 | 2019 |
Oncolytic reovirus enhances rituximab-mediated antibody-dependent cellular cytotoxicity against chronic lymphocytic leukaemia C Parrish, GB Scott, G Migneco, KJ Scott, LP Steele, E Ilett, EJ West, ... Leukemia 29 (9), 1799-1810, 2015 | 50 | 2015 |
Targeting human plasmacytoid dendritic cells through BDCA2 prevents skin inflammation and fibrosis in a novel xenotransplant mouse model of scleroderma RL Ross, C Corinaldesi, G Migneco, IM Carr, A Antanaviciute, ... Annals of the Rheumatic Diseases 80 (7), 920-929, 2021 | 32 | 2021 |
Virally programmed extracellular vesicles sensitize cancer cells to oncolytic virus and small molecule therapy ME Wedge, VA Jennings, MJF Crupi, J Poutou, T Jamieson, A Pelin, ... Nature communications 13 (1), 1898, 2022 | 28 | 2022 |
Silencing of caveolin-1 in fibroblasts as opposed to epithelial tumor cells results in increased tumor growth rate and chemoresistance in a human pancreatic cancer model K Kamposioras, C Tsimplouli, C Verbeke, A Anthoney, A Daoukopoulou, ... International journal of oncology 54 (2), 537-549, 2019 | 20 | 2019 |
Reovirus-induced cell-mediated immunity for the treatment of multiple myeloma within the resistant bone marrow niche LME Müller, G Migneco, GB Scott, J Down, S King, B Askar, V Jennings, ... Journal for immunotherapy of cancer 9 (3), 2021 | 14 | 2021 |
SAT0281 BIOSAMPLES FROM AT RISK SSC PATIENTS SHOW CLASSIC PATHOLOGICAL SIGNS OF SCLERODERMA: OPPORTUNITY FOR DIAGNOSIS OF PRE-CLINICAL SSC R Ross, I Georgiou, A Carriero, G Abignano, C Wasson, G Migneco, ... Annals of the Rheumatic Diseases 79 (Suppl 1), 1085-1085, 2020 | 1 | 2020 |
Evaluating the contribution of anti-myeloma immunity for the efficacy of oncolytic reovirus therapy LME Müller, C Parrish, G Migneco, GB Scott, M Holmes, AA Melcher, ... Clinical Cancer Research 23 (24_Supplement), 18-18, 2017 | 1 | 2017 |
The β-Secretase BACE1 Drives Fibroblast Activation in Systemic Sclerosis through the APP/β-Catenin/Notch Signaling Axis CW Wasson, E De Lorenzis, EM Clavane, RL Ross, KA Walker, ... Journal of Investigative Dermatology, 2024 | | 2024 |
Enhancing oncolytic virotherapy by exosome-mediated microRNA reprograming of the tumour microenvironment. V Jennings, R Rumbold-Hall, G Migneco, T Barr, K Reilly, N Ingram, ... bioRxiv, 2024.06. 07.597913, 2024 | | 2024 |
OP0113 The Beta Secretase Bace1 Drives Systemic Sclerosis Fibroblasts Activation Through Β-Catenin And Notch Signalling C Wasson, E Clavane, R Ross, G Migneco, C Antinozzi, J Brown, ... Annals of the Rheumatic Diseases 82 (Suppl 1), 75-75, 2023 | | 2023 |
The Beta secretase BACE1 drives Systemic Sclerosis fibroblasts activation through β-catenin and Notch signalling CW Wasson, EM Clavane, RL Ross, G Migneco, C Antinozzi, JMY Brown, ... bioRxiv, 2022.12. 22.521579, 2022 | | 2022 |
P163 Biosamples from at risk SSc patients show classic pathological signs of scleroderma: opportunity for a diagnosis of pre-clinical SSc RL Ross, I Georgiou, A Carriero, G Abignano, C Wasson, G Migneco, ... Rheumatology 59 (Supplement_2), keaa111. 158, 2020 | | 2020 |