| Bi-cycling the furin pathway: from TGN localization to pathogen activation and embryogenesis SS Molloy, ED Anderson, F Jean, G Thomas, SS Molloy, ED Anderson, ... Trends in cell biology 9 (1), 28-35, 1999 | 483 | 1999 |
| α1-Antitrypsin Portland, a bioengineered serpin highly selective for furin: Application as an antipathogenic agent F Jean, K Stella, L Thomas, G Liu, Y Xiang, AJ Reason, G Thomas Proceedings of the National Academy of Sciences 95 (13), 7293-7298, 1998 | 346 | 1998 |
| BMP-4 is proteolytically activated by furin and/or PC6 during vertebrate embryonic development Y Cui, F Jean, G Thomas, JL Christian The EMBO journal 17 (16), 4735-4743, 1998 | 328 | 1998 |
| Activation of the furin endoprotease is a multiple‐step process: requirements for acidification and internal propeptide cleavage ED Anderson, JK VanSlyke, CD Thulin, F Jean, G Thomas The EMBO journal, 1997 | 294 | 1997 |
| The pore-forming toxin proaerolysin is activated by furin L Abrami, M Fivaz, E Decroly, NG Seidah, F Jean, G Thomas, SH Leppla, ... Journal of Biological Chemistry 273 (49), 32656-32661, 1998 | 197 | 1998 |
| The activity and signaling range of mature BMP-4 is regulated by sequential cleavage at two sites within the prodomain of the precursor Y Cui, R Hackenmiller, L Berg, F Jean, T Nakayama, G Thomas, ... Genes & development 15 (21), 2797-2802, 2001 | 180 | 2001 |
| The convertases furin and PC1 can both cleave the human immunodeficiency virus (HIV)-1 envelope glycoprotein gp160 into gp120 (HIV-1 SU) and gp41 (HIV-I TM). E Decroly, M Vandenbranden, JM Ruysschaert, J Cogniaux, GS Jacob, ... Journal of Biological Chemistry 269 (16), 12240-12247, 1994 | 180 | 1994 |
| The Ordered and Compartment-specific Autoproteolytic Removal of the Furin Intramolecular Chaperone Is Required for Enzyme Activation∗ ED Anderson, SS Molloy, F Jean, H Fei, S Shimamura, G Thomas Journal of Biological Chemistry 277 (15), 12879-12890, 2002 | 172 | 2002 |
| Cerebral edema associated with meningiomas: possible role of a secretory-excretory phenomenon J Philippon, JF Foncin, R Grob, A Srour, M Poisson, BF Pertuiset Neurosurgery 14 (3), 295-301, 1984 | 158 | 1984 |
| A TMPRSS2 inhibitor acts as a pan-SARS-CoV-2 prophylactic and therapeutic T Shapira, IA Monreal, SP Dion, DW Buchholz, B Imbiakha, AD Olmstead, ... Nature 605 (7909), 340-348, 2022 | 144 | 2022 |
| Pandemic H1N1 influenza infection and vaccination in humans induces cross-protective antibodies that target the hemagglutinin stem CA Thomson, Y Wang, LM Jackson, M Olson, W Wang, A Liavonchanka, ... Frontiers in immunology 3, 87, 2012 | 131 | 2012 |
| Cleavages within the prodomain direct intracellular trafficking and degradation of mature bone morphogenetic protein-4 C Degnin, F Jean, G Thomas, JL Christian Molecular biology of the cell 15 (11), 5012-5020, 2004 | 124 | 2004 |
| Fluorescent peptidyl substrates as an aid in studying the substrate specificity of human prohormone convertase PC1 and human furin and designing a potent irreversible inhibitor F Jean, A Boudreault, A Basak, NG Seidah, C Lazure Journal of Biological Chemistry 270 (33), 19225-19231, 1995 | 111 | 1995 |
| Inhibition of soluble recombinant furin by human proteinase inhibitor 8 JR Dahlen, F Jean, G Thomas, DC Foster, W Kisiel Journal of Biological Chemistry 273 (4), 1851-1854, 1998 | 110 | 1998 |
| Enzymic characterization of murine and human prohormone convertase-1 (mPC1 and hPC1) expressed in mammalian GH4C1 cells F Jean, A Basak, N Rondeau, S Benjannet, GN Hendy, NG Seidah, ... Biochemical Journal 292 (3), 891-900, 1993 | 110 | 1993 |
| Temporal-and strain-specific host microRNA molecular signatures associated with swine-origin H1N1 and avian-origin H7N7 influenza A virus infection EK Loveday, V Svinti, S Diederich, J Pasick, F Jean Journal of virology 86 (11), 6109-6122, 2012 | 105 | 2012 |
| Human subtilase SKI-1/S1P is a master regulator of the HCV Lifecycle and a potential host cell target for developing indirect-acting antiviral agents AD Olmstead, W Knecht, I Lazarov, SB Dixit, F Jean PLoS pathogens 8 (1), e1002468, 2012 | 100 | 2012 |
| A protein-based therapeutic for human cytomegalovirus infection F Jean, L Thomas, SS Molloy, G Liu, MA Jarvis, JA Nelson, G Thomas Proceedings of the National Academy of Sciences 97 (6), 2864-2869, 2000 | 94 | 2000 |
| Identification of a pH sensor in the furin propeptide that regulates enzyme activation SF Feliciangeli, L Thomas, GK Scott, E Subbian, CH Hung, SS Molloy, ... Journal of Biological Chemistry 281 (23), 16108-16116, 2006 | 88 | 2006 |
| In vitro cleavage of internally quenched fluorogenic human proparathyroid hormone and proparathyroid-related peptide substrates by furin: Generation of a potent inhibitor C Lazure, D Gauthier, F Jean, A Boudreault, NG Seidah, HPJ Bennett, ... Journal of Biological Chemistry 273 (15), 8572-8580, 1998 | 74 | 1998 |
