Nitration of tyrosine 74 prevents human cytochrome c to play a key role in apoptosis signaling by blocking caspase-9 activation JM García-Heredia, I Díaz-Moreno, PM Nieto, M Orzáez, S Kocanis, ... Biochimica et Biophysica Acta (BBA)-Bioenergetics 1797 (6-7), 981-993, 2010 | 83 | 2010 |
Tyrosine phosphorylation turns alkaline transition into a biologically relevant process and makes human cytochrome c behave as an anti-apoptotic switch JM García-Heredia, A Díaz-Quintana, M Salzano, M Orzáez, ... JBIC Journal of Biological Inorganic Chemistry 16, 1155-1168, 2011 | 74 | 2011 |
Role of mitochondria in cancer stem cell resistance JM García-Heredia, A Carnero Cells 9 (7), 1693, 2020 | 71 | 2020 |
Acetylsalicylic acid induces programmed cell death in Arabidopsis cell cultures JM García-Heredia, M Hervás, MA De la Rosa, JA Navarro Planta 228, 89-97, 2008 | 67 | 2008 |
The cargo protein MAP17 (PDZK1IP1) regulates the cancer stem cell pool activating the Notch pathway by abducting NUMB JM Garcia-Heredia, A Lucena-Cacace, EM Verdugo-Sivianes, M Pérez, ... Clinical Cancer Research 23 (14), 3871-3883, 2017 | 64 | 2017 |
Decoding Warburg's hypothesis: tumor-related mutations in the mitochondrial respiratory chain JM Garcia-Heredia, A Carnero Oncotarget 6 (39), 41582, 2015 | 62 | 2015 |
Numb-like (NumbL) downregulation increases tumorigenicity, cancer stem cell-like properties and resistance to chemotherapy JM García-Heredia, EMV Sivianes, A Lucena-Cacace, S Molina-Pinelo, ... Oncotarget 7 (39), 63611, 2016 | 51 | 2016 |
Effect of Nitration on the Physicochemical and Kinetic Features of Wild-Type and Monotyrosine Mutants of Human Respiratory Cytochrome c V Rodríguez-Roldán, JM García-Heredia, JA Navarro, MAD Rosa, ... Biochemistry 47 (47), 12371-12379, 2008 | 51 | 2008 |
Nitration of tyrosines 46 and 48 induces the specific degradation of cytochrome c upon change of the heme iron state to high-spin I Díaz-Moreno, JM García-Heredia, A Díaz-Quintana, M Teixeira, A Miguel Biochimica et Biophysica Acta (BBA)-Bioenergetics 1807 (12), 1616-1623, 2011 | 44 | 2011 |
Perturbation of the Redox Site Structure of Cytochrome c Variants upon Tyrosine Nitration HK Ly, T Utesch, I Díaz-Moreno, JM Garcia-Heredia, MA De La Rosa, ... The Journal of Physical Chemistry B 116 (19), 5694-5702, 2012 | 42 | 2012 |
Specific nitration of tyrosines 46 and 48 makes cytochrome c assemble a non-functional apoptosome JM García-Heredia, I Díaz-Moreno, A Díaz-Quintana, M Orzáez, ... FEBS letters 586 (2), 154-158, 2012 | 40 | 2012 |
New markers for human ovarian cancer that link platinum resistance to the cancer stem cell phenotype and define new therapeutic combinations and diagnostic tools S Muñoz-Galván, B Felipe-Abrio, M García-Carrasco, J Domínguez-Piñol, ... Journal of Experimental & Clinical Cancer Research 38, 1-14, 2019 | 38 | 2019 |
Cytochrome c signalosome in mitochondria I Díaz-Moreno, JM García-Heredia, A Díaz-Quintana, MA De la Rosa European Biophysics Journal 40, 1301-1315, 2011 | 37 | 2011 |
Autoencoded DNA methylation data to predict breast cancer recurrence: Machine learning models and gene-weight significance L Macías-García, M Martinez-Ballesteros, JM Luna-Romera, ... Artificial Intelligence in Medicine 110, 101976, 2020 | 35 | 2020 |
A comparative kinetic analysis of the reactivity of plant, horse, and human respiratory cytochrome c towards cytochrome c oxidase V Rodríguez-Roldán, JM García-Heredia, JA Navarro, M Hervás, ... Biochemical and biophysical research communications 346 (3), 1108-1113, 2006 | 33 | 2006 |
Machine learning techniques to discover genes with potential prognosis role in Alzheimer’s disease using different biological sources M Martínez-Ballesteros, García-Heredia, J M., IA Nepomuceno-Chamorro, ... Information Fusion 36, 114-129, 2017 | 29 | 2017 |
MAP17 predicts sensitivity to platinum-based therapy, EGFR inhibitors and the proteasome inhibitor bortezomib in lung adenocarcinoma I Ferrer, Á Quintanal-Villalonga, S Molina-Pinelo, JM Garcia-Heredia, ... Journal of Experimental & Clinical Cancer Research 37, 1-13, 2018 | 24 | 2018 |
The cargo protein MAP17 (PDZK1IP1) regulates the immune microenvironment JM García-Heredia, A Carnero Oncotarget 8 (58), 98580, 2017 | 24 | 2017 |
Efficacy of bortezomib in sarcomas with high levels of MAP17 (PDZK1IP1) M Perez, J Peinado-Serrano, JM Garcia-Heredia, I Felipe-Abrio, C Tous, ... Oncotarget 7 (41), 67033, 2016 | 24 | 2016 |
Coordinated downregulation of Spinophilin and the catalytic subunits of PP1, PPP1CA/B/C, contributes to a worse prognosis in lung cancer EM Verdugo-Sivianes, L Navas, S Molina-Pinelo, I Ferrer, ... Oncotarget 8 (62), 105196, 2017 | 17 | 2017 |