| Quorum sensing controls adaptive immunity through the regulation of multiple CRISPR-Cas systems AG Patterson, SA Jackson, C Taylor, GB Evans, GPC Salmond, ... Molecular cell 64 (6), 1102-1108, 2016 | 215 | 2016 |
| Femtomolar transition state analogue inhibitors of 5′-methylthioadenosine/S-adenosylhomocysteine nucleosidase from Escherichia coli V Singh, GB Evans, DH Lenz, JM Mason, K Clinch, S Mee, GF Painter, ... Journal of Biological Chemistry 280 (18), 18265-18273, 2005 | 189 | 2005 |
| Achieving the ultimate physiological goal in transition state analogue inhibitors for purine nucleoside phosphorylase A Lewandowicz, PC Tyler, GB Evans, RH Furneaux, VL Schramm Journal of Biological Chemistry 278 (34), 31465-31468, 2003 | 180 | 2003 |
| Plasmodium falciparum purine nucleoside phosphorylase: crystal structures, immucillin inhibitors, and dual catalytic function W Shi, LM Ting, GA Kicska, A Lewandowicz, PC Tyler, GB Evans, ... Journal of Biological Chemistry 279 (18), 18103-18106, 2004 | 176 | 2004 |
| Potentiation of methicillin activity against methicillin-resistant Staphylococcus aureus by diterpenes K Nicolson, G Evans, PW O'Toole FEMS Microbiology Letters 179 (2), 233-239, 1999 | 171 | 1999 |
| Purine-less Death in Plasmodium falciparumInduced by Immucillin-H, a Transition State Analogue of Purine Nucleoside Phosphorylase GA Kicska, PC Tyler, GB Evans, RH Furneaux, VL Schramm, K Kim Journal of Biological Chemistry 277 (5), 3226-3231, 2002 | 164 | 2002 |
| Targeting a novel Plasmodium falciparum purine recycling pathway with specific immucillins LM Ting, W Shi, A Lewandowicz, V Singh, A Mwakingwe, MR Birck, ... Journal of Biological Chemistry 280 (10), 9547-9554, 2005 | 148 | 2005 |
| Transition state analogue inhibitors of purine nucleoside phosphorylase from Plasmodium falciparum GA Kicska, PC Tyler, GB Evans, RH Furneaux, K Kim, VL Schramm Journal of Biological Chemistry 277 (5), 3219-3225, 2002 | 131 | 2002 |
| Exploring structure− activity relationships of transition state analogues of human purine nucleoside phosphorylase GB Evans, RH Furneaux, A Lewandowicz, VL Schramm, PC Tyler Journal of medicinal chemistry 46 (15), 3412-3423, 2003 | 127 | 2003 |
| Synthesis of second-generation transition state analogues of human purine nucleoside phosphorylase GB Evans, RH Furneaux, A Lewandowicz, VL Schramm, PC Tyler Journal of medicinal chemistry 46 (24), 5271-5276, 2003 | 124 | 2003 |
| Addition of Lithiated 9-Deazapurine Derivatives to a Carbohydrate Cyclic Imine: Convergent Synthesis of the Aza-C-nucleoside Immucillins GB Evans, RH Furneaux, TL Hutchison, HS Kezar, PE Morris, ... The Journal of organic chemistry 66 (17), 5723-5730, 2001 | 124 | 2001 |
| Synthesis of transition state analogue inhibitors for purine nucleoside phosphorylase and N-riboside hydrolases GB Evans, RH Furneaux, GJ Gainsford, VL Schramm, PC Tyler Tetrahedron 56 (19), 3053-3062, 2000 | 110 | 2000 |
| Synthesis of a transition state analogue inhibitor of purine nucleoside phosphorylase via the Mannich reaction GB Evans, RH Furneaux, PC Tyler, VL Schramm Organic Letters 5 (20), 3639-3640, 2003 | 106 | 2003 |
| Azetidine Based Transition State Analogue Inhibitors of N-Ribosyl Hydrolases and Phosphorylases GB Evans, RH Furneaux, B Greatrex, AS Murkin, VL Schramm, PC Tyler Journal of medicinal chemistry 51 (4), 948-956, 2008 | 101 | 2008 |
| Growth and metastases of human lung cancer are inhibited in mouse xenografts by a transition state analogue of 5′-methylthioadenosine phosphorylase I Basu, J Locker, MB Cassera, TJ Belbin, EF Merino, X Dong, I Hemeon, ... Journal of Biological Chemistry 286 (6), 4902-4911, 2011 | 99 | 2011 |
| Iminoribitol transition state analogue inhibitors of protozoan nucleoside hydrolases RW Miles, PC Tyler, GB Evans, RH Furneaux, DW Parkin, VL Schramm Biochemistry 38 (40), 13147-13154, 1999 | 99 | 1999 |
| Four generations of transition-state analogues for human purine nucleoside phosphorylase MC Ho, W Shi, A Rinaldo-Matthis, PC Tyler, GB Evans, K Clinch, SC Almo, ... Proceedings of the National Academy of Sciences 107 (11), 4805-4812, 2010 | 94 | 2010 |
| Structural Rationale for the Affinity of Pico-and Femtomolar Transition State Analogues of Escherichia coli 5′-Methylthioadenosine/S-Adenosylhomocysteine Nucleosidase*♦ JE Lee, V Singh, GB Evans, PC Tyler, RH Furneaux, KA Cornell, ... Journal of Biological Chemistry 280 (18), 18274-18282, 2005 | 93 | 2005 |
| Picomolar transition state analogue inhibitors of human 5 ‘-methylthioadenosine phosphorylase and X-ray structure with MT-Immucillin-A V Singh, W Shi, GB Evans, PC Tyler, RH Furneaux, SC Almo, ... Biochemistry 43 (1), 9-18, 2004 | 91 | 2004 |
| Structure and Inhibition of a Quorum Sensing Target from Streptococcus pneumoniae V Singh, W Shi, SC Almo, GB Evans, RH Furneaux, PC Tyler, GF Painter, ... Biochemistry 45 (43), 12929-12941, 2006 | 89 | 2006 |
