| Senolytics reduce coronavirus-related mortality in old mice CD Camell, MJ Yousefzadeh, Y Zhu, LGPL Prata, MA Huggins, M Pierson, ... Science 373 (6552), eabe4832, 2021 | 271 | 2021 |
| CD38 ecto-enzyme in immune cells is induced during aging and regulates NAD+ and NMN levels CCS Chini, TR Peclat, GM Warner, S Kashyap, JM Espindola-Netto, ... Nature metabolism 2 (11), 1284-1304, 2020 | 253 | 2020 |
| The pharmacology of CD38/NADase: an emerging target in cancer and diseases of aging EN Chini, CCS Chini, JME Netto, GC de Oliveira, W van Schooten Trends in pharmacological sciences 39 (4), 424-436, 2018 | 202 | 2018 |
| SARS-CoV-2 causes senescence in human cells and exacerbates the senescence-associated secretory phenotype through TLR-3 U Tripathi, R Nchioua, LGPL Prata, Y Zhu, EOW Gerdes, N Giorgadze, ... Aging (albany NY) 13 (18), 21838, 2021 | 80 | 2021 |
| Strategies for late phase preclinical and early clinical trials of senolytics EOW Gerdes, A Misra, JME Netto, T Tchkonia, JL Kirkland Mechanisms of ageing and development 200, 111591, 2021 | 72 | 2021 |
| A methionine-Mettl3-N6-methyladenosine axis promotes polycystic kidney disease H Ramalingam, S Kashyap, P Cobo-Stark, A Flaten, CM Chang, ... Cell metabolism 33 (6), 1234-1247. e7, 2021 | 63 | 2021 |
| Orally-active, clinically-translatable senolytics restore α-Klotho in mice and humans Y Zhu, LGPL Prata, EOW Gerdes, JME Netto, T Pirtskhalava, N Giorgadze, ... EBioMedicine 77, 2022 | 51 | 2022 |
| Preclinical efficacy of the novel competitive NAMPT inhibitor STF-118804 in pancreatic cancer JM Espindola-Netto, CCS Chini, M Tarragó, E Wang, S Dutta, K Pal, ... Oncotarget 8 (49), 85054, 2017 | 48 | 2017 |
| Antidiabetic activity of Sedum dendroideum: Metabolic enzymes as putative targets for the bioactive flavonoid kaempferitrin D Da Silva, LM Casanova, MC Marcondes, JM Espindola‐Netto, ... IUBMB life 66 (5), 361-370, 2014 | 43 | 2014 |
| Targeting CD38-dependent NAD+ metabolism to mitigate multiple organ fibrosis B Shi, W Wang, B Korman, L Kai, Q Wang, J Wei, S Bale, RG Marangoni, ... Iscience 24 (1), 2021 | 41 | 2021 |
| SIRT1-activating compounds (STAC) negatively regulate pancreatic cancer cell growth and viability through a SIRT1 lysosomal-dependent pathway CCS Chini, JM Espindola-Netto, G Mondal, AMG Guerrico, V Nin, ... Clinical Cancer Research 22 (10), 2496-2507, 2016 | 40 | 2016 |
| Interleukin-6 in patients with heart failure and preserved ejection fraction A Alogna, KE Koepp, M Sabbah, JM Espindola Netto, MD Jensen, ... Heart Failure 11 (11), 1549-1561, 2023 | 32 | 2023 |
| Exogenous citrate impairs glucose tolerance and promotes visceral adipose tissue inflammation in mice JGB Leandro, JM Espindola-Netto, MCF Vianna, LS Gomez, TM DeMaria, ... British Journal of Nutrition 115 (6), 967-973, 2016 | 29 | 2016 |
| The Use of NMR Metabolite Profiling and in vivo Hypoglycemic Assay for Comparison of Unfractionated Aqueous Leaf Extracts of Two Ocimum Species LM Casanova, JM Espíndola‐Netto, LW Tinoco, M Sola‐Penna, SS Costa Chemistry & Biodiversity 13 (6), 686-694, 2016 | 18 | 2016 |
| Wnt-induced, TRP53-mediated cell cycle arrest of precursors underlies interstitial cell of cajal depletion during aging Y Hayashi, DT Asuzu, MR Bardsley, GB Gajdos, SM Kvasha, DR Linden, ... Cellular and Molecular Gastroenterology and Hepatology 11 (1), 117-145, 2021 | 15 | 2021 |
| Clotrimazole is effective for the regression of endometriotic implants in a Wistar rat experimental model of endometriosis DE Machado, JA Perini, EM de Mendonça, JR Branco, ... Molecular and cellular endocrinology 476, 17-26, 2018 | 13 | 2018 |
| Circulating monocytes expressing senescence‐associated features are enriched in COVID‐19 patients with severe disease Y Lin, DF Postma, LS Steeneken, LS Melo Dos Santos, JL Kirkland, ... Aging Cell 22 (12), e14011, 2023 | 11 | 2023 |
| Past and future directions for research on cellular senescence Y Zhu, ZP Anastasiadis, JME Netto, T Evans, T Tchkonia, JL Kirkland Cold Spring Harbor Perspectives in Medicine 14 (2), a041205, 2024 | 9 | 2024 |
| Endogenous metabolism in endothelial and immune cells generates most of the tissue vitamin B3 (nicotinamide) JD Zeidler, CCS Chini, KS Kanamori, S Kashyap, JM Espindola-Netto, ... Iscience 25 (11), 2022 | 3 | 2022 |
| Clinical validation of C12FDG as a marker associated with senescence and osteoarthritic phenotypes WS Hambright, VR Duke, AD Goff, AW Goff, LT Minas, H Kloser, X Gao, ... Aging cell, e14113, 2024 | 2 | 2024 |
