Simulation and prediction of in vivo drug metabolism in human populations from in vitro data A Rostami-Hodjegan, GT Tucker Nature reviews Drug discovery 6 (2), 140-148, 2007 | 590 | 2007 |
The Simcyp® Population-based ADME Simulator M Jamei, S Marciniak, K Feng, A Barnett, G Tucker, A Rostami-Hodjegan Expert opinion on drug metabolism & toxicology 5 (2), 211-223, 2009 | 579 | 2009 |
Prediction of the clearance of eleven drugs and associated variability in neonates, infants and children TN Johnson, A Rostami-Hodjegan, GT Tucker Clinical pharmacokinetics 45, 931-956, 2006 | 574 | 2006 |
Scaling factors for the extrapolation of in vivo metabolic drug clearance from in vitro data: reaching a consensus on values of human micro-somal protein and hepatocellularity … ZE Barter, MK Bayliss, PH Beaune, AR Boobis, DJ Carlile, RJ Edwards, ... Current drug metabolism 8 (1), 33-45, 2007 | 495 | 2007 |
Population-based mechanistic prediction of oral drug absorption M Jamei, D Turner, J Yang, S Neuhoff, S Polak, A Rostami-Hodjegan, ... The AAPS journal 11, 225-237, 2009 | 487 | 2009 |
The bisphosphonate, zoledronic acid, induces apoptosis of breast cancer cells: evidence for synergy with paclitaxel SP Jagdev, RE Coleman, CM Shipman, A Rostami-H, PI Croucher British journal of cancer 84 (8), 1126-1134, 2001 | 461 | 2001 |
A framework for assessing inter-individual variability in pharmacokinetics using virtual human populations and integrating general knowledge of physical chemistry, biology … M Jamei, GL Dickinson, A Rostami-Hodjegan Drug metabolism and pharmacokinetics 24 (1), 53-75, 2009 | 391 | 2009 |
Anatomical, physiological and metabolic changes with gestational age during normal pregnancy: a database for parameters required in physiologically based pharmacokinetic modelling K Abduljalil, P Furness, TN Johnson, A Rostami-Hodjegan, H Soltani Clinical pharmacokinetics 51, 365-396, 2012 | 385 | 2012 |
Prediction of intestinal first-pass drug metabolism J Yang, M Jamei, KR Yeo, GT Tucker, A Rostami-Hodjegan Current drug metabolism 8 (7), 676-684, 2007 | 377 | 2007 |
Modified-release hydrocortisone to provide circadian cortisol profiles M Debono, C Ghobadi, A Rostami-Hodjegan, H Huatan, MJ Campbell, ... The Journal of Clinical Endocrinology & Metabolism 94 (5), 1548-1554, 2009 | 376 | 2009 |
PBPK models for the prediction of in vivo performance of oral dosage forms ES Kostewicz, L Aarons, M Bergstrand, MB Bolger, A Galetin, O Hatley, ... European Journal of Pharmaceutical Sciences 57, 300-321, 2014 | 334 | 2014 |
Physiologically Based Pharmacokinetics Joined With In Vitro–In Vivo Extrapolation of ADME: A Marriage Under the Arch of Systems Pharmacology A Rostami‐Hodjegan Clinical Pharmacology & Therapeutics 92 (1), 50-61, 2012 | 334 | 2012 |
Changes in liver volume from birth to adulthood: a meta-analysis TN Johnson, GT Tucker, SM Tanner, A Rostami-Hodjegan Liver transplantation 11 (12), 1481-1493, 2005 | 333 | 2005 |
Influence of dose, cigarette smoking, age, sex, and metabolic activity on plasma clozapine concentrations: a predictive model and nomograms to aid clozapine dose adjustment and … A Rostami-Hodjegan, AM Amin, EP Spencer, MS Lennard, GT Tucker, ... Journal of clinical psychopharmacology 24 (1), 70-78, 2004 | 302 | 2004 |
In vivo methods for drug absorption–comparative physiologies, model selection, correlations with in vitro methods (IVIVC), and applications for formulation/API/excipient … E Sjögren, B Abrahamsson, P Augustijns, D Becker, MB Bolger, ... European Journal of Pharmaceutical Sciences 57, 99-151, 2014 | 299 | 2014 |
Weight‐related dosing, timing and monitoring hydrocortisone replacement therapy in patients with adrenal insufficiency PM Mah, RC Jenkins, A Rostami‐Hodjegan, J Newell‐Price, A Doane, ... Clinical endocrinology 61 (3), 367-375, 2004 | 282 | 2004 |
Combining the ‘bottom up’and ‘top down’approaches in pharmacokinetic modelling: fitting PBPK models to observed clinical data N Tsamandouras, A Rostami‐Hodjegan, L Aarons British journal of clinical pharmacology 79 (1), 48-55, 2015 | 267 | 2015 |
Cytochrome p450 turnover: regulation of synthesis and degradation, methods for determining rates, and implications for the prediction of drug interactions J Yang, M Liao, M Shou, M Jamei, KR Yeo, GT Tucker, ... Current drug metabolism 9 (5), 384-393, 2008 | 255 | 2008 |
‘In silico’simulations to assess the ‘in vivo’consequences of ‘in vitro’metabolic drug–drug interactions A Rostami-Hodjegan, G Tucker Drug Discovery Today: Technologies 1 (4), 441-448, 2004 | 248 | 2004 |
Predicting drug clearance from recombinantly expressed CYPs: intersystem extrapolation factors NJ Proctor, GT Tucker, A Rostami-Hodjegan Xenobiotica 34 (2), 151-178, 2004 | 244 | 2004 |