| Small-molecule–induced DNA damage identifies alternative DNA structures in human genes R Rodriguez, KM Miller, JV Forment, CR Bradshaw, M Nikan, S Britton, ... Nature chemical biology 8 (3), 301-310, 2012 | 713 | 2012 |
| A non-canonical DNA structure is a binding motif for the transcription factor SP1 in vitro EA Raiber, R Kranaster, E Lam, M Nikan, S Balasubramanian Nucleic acids research 40 (4), 1499-1508, 2012 | 225 | 2012 |
| Comparison of partially and fully chemically-modified siRNA in conjugate-mediated delivery in vivo MR Hassler, AA Turanov, JF Alterman, RA Haraszti, AH Coles, MF Osborn, ... Nucleic acids research 46 (5), 2185-2196, 2018 | 158 | 2018 |
| Hydrophobicity drives the systemic distribution of lipid-conjugated siRNAs via lipid transport pathways MF Osborn, AH Coles, A Biscans, RA Haraszti, L Roux, S Davis, S Ly, ... Nucleic acids research 47 (3), 1070-1081, 2019 | 117 | 2019 |
| Docosahexaenoic acid conjugation enhances distribution and safety of siRNA upon local administration in mouse brain M Nikan, MF Osborn, AH Coles, BMDC Godinho, LM Hall, RA Haraszti, ... Molecular Therapy-Nucleic Acids 5, 2016 | 92 | 2016 |
| Template-assembled synthetic G-quartets (TASQs) M Nikan University of British Columbia, 2008 | 74 | 2008 |
| Overcoming the challenges of tissue delivery for oligonucleotide therapeutics T Gökirmak, M Nikan, S Wiechmann, TP Prakash, M Tanowitz, PP Seth Trends in pharmacological sciences 42 (7), 588-604, 2021 | 60 | 2021 |
| Guanabenz (Wytensin™) selectively enhances uptake and efficacy of hydrophobically modified siRNAs MF Osborn, JF Alterman, M Nikan, H Cao, MC Didiot, MR Hassler, ... Nucleic acids research 43 (18), 8664-8672, 2015 | 50 | 2015 |
| An acetylene‐bridged 6, 8‐purine dimer as a fluorescent switch‐on probe for parallel G‐quadruplexes M Nikan, M Di Antonio, K Abecassis, K McLuckie, S Balasubramanian Angewandte Chemie International Edition 52 (5), 1428-1431, 2013 | 50 | 2013 |
| Glucagon like peptide 1 receptor agonists for targeted delivery of antisense oligonucleotides to pancreatic beta cell L Knerr, TP Prakash, R Lee, WJ Drury III, M Nikan, W Fu, E Pirie, LD Maria, ... Journal of the American Chemical Society 143 (9), 3416-3429, 2021 | 47 | 2021 |
| Pharmacokinetic profiling of conjugated therapeutic oligonucleotides: a high-throughput method based upon serial blood microsampling coupled to peptide nucleic acid … BMDC Godinho, JW Gilbert, RA Haraszti, AH Coles, A Biscans, L Roux, ... nucleic acid therapeutics 27 (6), 323-334, 2017 | 44 | 2017 |
| Cation-complexation behavior of template-assembled synthetic G-quartets M Nikan, JC Sherman The Journal of Organic Chemistry 74 (15), 5211-5218, 2009 | 43 | 2009 |
| Hydrophobicity of lipid-conjugated siRNAs predicts productive loading to small extracellular vesicles A Biscans, RA Haraszti, D Echeverria, R Miller, MC Didiot, M Nikan, ... Molecular Therapy 26 (6), 1520-1528, 2018 | 40 | 2018 |
| Transvascular delivery of hydrophobically modified siRNAs: gene silencing in the rat brain upon disruption of the blood-brain barrier BMDC Godinho, N Henninger, J Bouley, JF Alterman, RA Haraszti, ... Molecular Therapy 26 (11), 2580-2591, 2018 | 38 | 2018 |
| Synthesis and Evaluation of Parenchymal Retention and Efficacy of a Metabolically Stable O-Phosphocholine-N-docosahexaenoyl-l-serine siRNA Conjugate in … M Nikan, MF Osborn, AH Coles, A Biscans, BMDC Godinho, RA Haraszti, ... Bioconjugate chemistry 28 (6), 1758-1766, 2017 | 38 | 2017 |
| Targeted delivery of antisense oligonucleotides using neurotensin peptides M Nikan, M Tanowitz, CA Dwyer, M Jackson, HJ Gaus, EE Swayze, ... Journal of Medicinal Chemistry 63 (15), 8471-8484, 2020 | 32 | 2020 |
| Synthesis of a water-soluble triazole-linked cavitand–guanosine conjugate M Nikan, GAL Bare, JC Sherman Tetrahedron letters 52 (15), 1791-1793, 2011 | 20 | 2011 |
| Bioactive conjugates for oligonucleotide delivery A Khvorova, M Nikan, M Hassler, M Osborn, R Haraszti, A Coles, ... US Patent 10,633,653, 2020 | 17 | 2020 |
| Crystal Structure of a Template‐Assembled Synthetic G‐Quadruplex M Nikan, BO Patrick, JC Sherman ChemBioChem 13 (10), 1413-1415, 2012 | 16 | 2012 |
| Targeted Delivery of Antisense Oligonucleotides Through Angiotensin Type 1 Receptor C Kuo, M Nikan, ST Yeh, AE Chappell, M Tanowitz, PP Seth, TP Prakash, ... nucleic acid therapeutics 32 (4), 300-311, 2022 | 5 | 2022 |
