| Executioner caspase-3,-6, and-7 perform distinct, non-redundant roles during the demolition phase of apoptosis EA Slee, C Adrain, SJ Martin Journal of biological Chemistry 276 (10), 7320-7326, 2001 | 1530 | 2001 |
| The mitochondrial apoptosome: a killer unleashed by the cytochrome seas C Adrain, SJ Martin Trends in biochemical sciences 26 (6), 390-397, 2001 | 847 | 2001 |
| Serial killers: ordering caspase activation events in apoptosis EA Slee, C Adrain, SJ Martin Cell Death & Differentiation 6 (11), 1067-1074, 1999 | 650 | 1999 |
| Apoptosis‐associated release of Smac/DIABLO from mitochondria requires active caspases and is blocked by Bcl‐2 C Adrain, EM Creagh, SJ Martin The EMBO journal, 2001 | 620 | 2001 |
| Analysis of the composition, assembly kinetics and activity of native Apaf‐1 apoptosomes MM Hill, C Adrain, PJ Duriez, EM Creagh, SJ Martin The EMBO journal 23 (10), 2134-2145, 2004 | 501 | 2004 |
| Tumor necrosis factor signaling requires iRhom2 to promote trafficking and activation of TACE C Adrain, M Zettl, Y Christova, N Taylor, M Freeman Science 335 (6065), 225, 2012 | 460 | 2012 |
| Role for CED-9 and Egl-1 as regulators of mitochondrial fission and fusion dynamics P Delivani, C Adrain, RC Taylor, PJ Duriez, SJ Martin Molecular cell 21 (6), 761-773, 2006 | 238 | 2006 |
| Molecular ordering of the caspase activation cascade initiated by the cytotoxic T lymphocyte/natural killer (CTL/NK) protease granzyme B C Adrain, BM Murphy, SJ Martin Journal of Biological Chemistry 280 (6), 4663-4673, 2005 | 233 | 2005 |
| Rhomboid family pseudoproteases use the ER quality control machinery to regulate intercellular signaling M Zettl, C Adrain, K Strisovsky, V Lastun, M Freeman Cell 145 (1), 79-91, 2011 | 179 | 2011 |
| New lives for old: evolution of pseudoenzyme function illustrated by iRhoms C Adrain, M Freeman Nature reviews Molecular cell biology 13 (8), 489-498, 2012 | 176 | 2012 |
| Regulation of apoptotic protease activating factor-1 oligomerization and apoptosis by the WD-40 repeat region C Adrain, EA Slee, MT Harte, SJ Martin Journal of Biological Chemistry 274 (30), 20855-20860, 1999 | 169 | 1999 |
| Portrait of a killer: the mitochondrial apoptosome emerges from the shadows MM Hill, C Adrain, SJ Martin Molecular interventions 3 (1), 19, 2003 | 166 | 2003 |
| Pro-apoptotic proteins released from the mitochondria regulate the protein composition and caspase-processing activity of the native Apaf-1/caspase-9 apoptosome complex D Twiddy, DG Brown, C Adrain, R Jukes, SJ Martin, GM Cohen, ... Journal of Biological Chemistry 279 (19), 19665-19682, 2004 | 160 | 2004 |
| Mammalian iRhoms have distinct physiological functions including an essential role in TACE regulation Y Christova, C Adrain, P Bambrough, A Ibrahim, M Freeman EMBO reports 14 (10), 884-890, 2013 | 153 | 2013 |
| The Apoptosome Pathway to Caspase Activation in Primary Human Neutrophils Exhibits Dramatically Reduced Requirements for Cytochrome c BM Murphy, AJ O'Neill, C Adrain, RWG Watson, SJ Martin The Journal of experimental medicine 197 (5), 625-632, 2003 | 151 | 2003 |
| Human and murine granzyme B exhibit divergent substrate preferences SP Cullen, C Adrain, AU Lüthi, PJ Duriez, SJ Martin The Journal of cell biology 176 (4), 435-444, 2007 | 150 | 2007 |
| CARDINAL, a novel caspase recruitment domain protein, is an inhibitor of multiple NF-κB activation pathways L Bouchier-Hayes, H Conroy, H Egan, C Adrain, EM Creagh, ... Journal of Biological Chemistry 276 (47), 44069-44077, 2001 | 134 | 2001 |
| Mammalian EGF receptor activation by the rhomboid protease RHBDL2 C Adrain, K Strisovsky, M Zettl, L Hu, MK Lemberg, M Freeman EMBO reports 12 (5), 421-427, 2011 | 128 | 2011 |
| The cytotoxic lymphocyte protease, granzyme B, targets the cytoskeleton and perturbs microtubule polymerization dynamics C Adrain, PJ Duriez, G Brumatti, P Delivani, SJ Martin Journal of biological chemistry 281 (12), 8118-8125, 2006 | 111 | 2006 |
| Phosphorylation of iRhom2 controls stimulated proteolytic shedding by the metalloprotease ADAM17/TACE M Cavadas, I Oikonomidi, CJ Gaspar, E Burbridge, M Badenes, I Félix, ... Cell Reports 21 (3), 745-757, 2017 | 106 | 2017 |
