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George Hedger
George Hedger
Vertex Pharmaceuticals, D. E. Shaw Research, University of Oxford
在 vrtx.com 的电子邮件经过验证
标题
引用次数
引用次数
年份
Structural basis of Smoothened regulation by its extracellular domains
EFX Byrne, R Sircar, PS Miller, G Hedger, G Luchetti, S Nachtergaele, ...
Nature 535 (7613), 517-522, 2016
3542016
PtdIns (4, 5) P 2 stabilizes active states of GPCRs and enhances selectivity of G-protein coupling
HY Yen, KK Hoi, I Liko, G Hedger, MR Horrell, W Song, D Wu, P Heine, ...
Nature 559 (7714), 423-427, 2018
2562018
Lipid interaction sites on channels, transporters and receptors: recent insights from molecular dynamics simulations
G Hedger, MSP Sansom
Biochimica et Biophysica Acta (BBA)-Biomembranes 1858 (10), 2390-2400, 2016
1712016
The juxtamembrane regions of human receptor tyrosine kinases exhibit conserved interaction sites with anionic lipids
G Hedger, MSP Sansom, H Koldsø
Scientific reports 5 (1), 9198, 2015
1162015
Convergence and sampling in determining free energy landscapes for membrane protein association
J Domański, G Hedger, RB Best, PJ Stansfeld, MSP Sansom
The journal of physical chemistry B 121 (15), 3364-3375, 2017
942017
Cholesterol interaction sites on the transmembrane domain of the hedgehog signal transducer and class FG protein-coupled receptor smoothened
G Hedger, H Koldsø, M Chavent, C Siebold, R Rohatgi, MSP Sansom
Structure 27 (3), 549-559. e2, 2019
822019
Lipid-loving ANTs: molecular simulations of cardiolipin interactions and the organization of the adenine nucleotide translocase in model mitochondrial membranes
G Hedger, SL Rouse, J Domański, M Chavent, H Koldsø, MSP Sansom
Biochemistry 55 (45), 6238-6249, 2016
622016
Free energy landscape of lipid interactions with regulatory binding sites on the transmembrane domain of the EGF receptor
G Hedger, D Shorthouse, H Koldsø, MSP Sansom
The Journal of Physical Chemistry B 120 (33), 8154-8163, 2016
572016
Interactions of the EphA2 kinase domain with PIPs in membranes: implications for receptor function
M Chavent, D Karia, AC Kalli, J Domański, AL Duncan, G Hedger, ...
Structure 26 (7), 1025-1034. e2, 2018
392018
Lipid interactions of a ciliary membrane TRP channel: Simulation and structural studies of polycystin-2
Q Wang, RA Corey, G Hedger, P Aryal, M Grieben, C Nasrallah, ...
Structure 28 (2), 169-184. e5, 2020
382020
Molecular simulations of glycolipids: Towards mammalian cell membrane models
D Shorthouse, G Hedger, H Koldsø, MSP Sansom
Biochimie 120, 105-109, 2016
352016
GPCRs: What can we learn from molecular dynamics simulations?
N Velgy, G Hedger, PC Biggin
Computational Methods for GPCR Drug Discovery, 133-158, 2018
142018
Computational Methods for GPCR Drug Discovery
A Heifetz
Humana Press, 2018
32018
PIP2 stabilises active states of GPCRs and enhances the selectivity
H Yen, K Hoi, I Liko, G Hedger, M Horrell, W Song, D Wu, P Heine, ...
Nature 559, 2018
12018
A PIP2 binding site on a human TRP channel: Simulation studies of PKD2
Q Wang, G Hedger, P Aryal, J Shi, EP Carpenter, MSP Sansom
Biophysical Journal 114 (3), 397a, 2018
12018
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