Structural basis of Smoothened regulation by its extracellular domains EFX Byrne, R Sircar, PS Miller, G Hedger, G Luchetti, S Nachtergaele, ... Nature 535 (7613), 517-522, 2016 | 354 | 2016 |
PtdIns (4, 5) P 2 stabilizes active states of GPCRs and enhances selectivity of G-protein coupling HY Yen, KK Hoi, I Liko, G Hedger, MR Horrell, W Song, D Wu, P Heine, ... Nature 559 (7714), 423-427, 2018 | 256 | 2018 |
Lipid interaction sites on channels, transporters and receptors: recent insights from molecular dynamics simulations G Hedger, MSP Sansom Biochimica et Biophysica Acta (BBA)-Biomembranes 1858 (10), 2390-2400, 2016 | 171 | 2016 |
The juxtamembrane regions of human receptor tyrosine kinases exhibit conserved interaction sites with anionic lipids G Hedger, MSP Sansom, H Koldsø Scientific reports 5 (1), 9198, 2015 | 116 | 2015 |
Convergence and sampling in determining free energy landscapes for membrane protein association J Domański, G Hedger, RB Best, PJ Stansfeld, MSP Sansom The journal of physical chemistry B 121 (15), 3364-3375, 2017 | 94 | 2017 |
Cholesterol interaction sites on the transmembrane domain of the hedgehog signal transducer and class FG protein-coupled receptor smoothened G Hedger, H Koldsø, M Chavent, C Siebold, R Rohatgi, MSP Sansom Structure 27 (3), 549-559. e2, 2019 | 82 | 2019 |
Lipid-loving ANTs: molecular simulations of cardiolipin interactions and the organization of the adenine nucleotide translocase in model mitochondrial membranes G Hedger, SL Rouse, J Domański, M Chavent, H Koldsø, MSP Sansom Biochemistry 55 (45), 6238-6249, 2016 | 62 | 2016 |
Free energy landscape of lipid interactions with regulatory binding sites on the transmembrane domain of the EGF receptor G Hedger, D Shorthouse, H Koldsø, MSP Sansom The Journal of Physical Chemistry B 120 (33), 8154-8163, 2016 | 57 | 2016 |
Interactions of the EphA2 kinase domain with PIPs in membranes: implications for receptor function M Chavent, D Karia, AC Kalli, J Domański, AL Duncan, G Hedger, ... Structure 26 (7), 1025-1034. e2, 2018 | 39 | 2018 |
Lipid interactions of a ciliary membrane TRP channel: Simulation and structural studies of polycystin-2 Q Wang, RA Corey, G Hedger, P Aryal, M Grieben, C Nasrallah, ... Structure 28 (2), 169-184. e5, 2020 | 38 | 2020 |
Molecular simulations of glycolipids: Towards mammalian cell membrane models D Shorthouse, G Hedger, H Koldsø, MSP Sansom Biochimie 120, 105-109, 2016 | 35 | 2016 |
GPCRs: What can we learn from molecular dynamics simulations? N Velgy, G Hedger, PC Biggin Computational Methods for GPCR Drug Discovery, 133-158, 2018 | 14 | 2018 |
Computational Methods for GPCR Drug Discovery A Heifetz Humana Press, 2018 | 3 | 2018 |
PIP2 stabilises active states of GPCRs and enhances the selectivity H Yen, K Hoi, I Liko, G Hedger, M Horrell, W Song, D Wu, P Heine, ... Nature 559, 2018 | 1 | 2018 |
A PIP2 binding site on a human TRP channel: Simulation studies of PKD2 Q Wang, G Hedger, P Aryal, J Shi, EP Carpenter, MSP Sansom Biophysical Journal 114 (3), 397a, 2018 | 1 | 2018 |