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Karan H. Muchhala
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Effects of acute and repeated treatment with the biased mu opioid receptor agonist TRV130 (oliceridine) on measures of antinociception, gastrointestinal function, and abuse …
AA Altarifi, B David, KH Muchhala, BE Blough, H Akbarali, SS Negus
Journal of Psychopharmacology 31 (6), 730-739, 2017
1582017
Chemotherapy induced gastrointestinal toxicities
HI Akbarali, KH Muchhala, DK Jessup, S Cheatham
Advances in cancer research 155, 131-166, 2022
262022
Glycine and GABAA ultra-sensitive ethanol receptors as novel tools for alcohol and brain research
A Naito, KH Muchhala, L Asatryan, JR Trudell, GE Homanics, DI Perkins, ...
Molecular Pharmacology 86 (6), 635-646, 2014
152014
Role of β-arrestin-2 in short-and long-term opioid tolerance in the dorsal root ganglia
KH Muchhala, JC Jacob, WL Dewey, HI Akbarali
European journal of pharmacology 899, 174007, 2021
132021
Manipulations of extracellular Loop 2 in α1 GlyR ultra-sensitive ethanol receptors (USERs) enhance receptor sensitivity to isoflurane, ethanol, and lidocaine, but not propofol
A Naito, KH Muchhala, J Trang, L Asatryan, JR Trudell, GE Homanics, ...
Neuroscience 297, 68-77, 2015
82015
Sex-specific role for serotonin 5-HT2A receptor in modulation of opioid-induced antinociception and reward in mice
S Sierra, KH Muchhala, DK Jessup, KM Contreras, UH Shah, DL Stevens, ...
Neuropharmacology 209, 108988, 2022
72022
The guts of the opioid crisis
KH Muchhala, JC Jacob, M Kang, WL Dewey, HI Akbarali
Physiology 36 (5), 315-323, 2021
52021
Morphine exacerbates experimental colitis-induced depression of nesting in mice
SM Cheatham, KH Muchhala, E Koseli, JC Jacob, E Komla, SS Negus, ...
Frontiers in Pain Research 2, 738499, 2021
42021
The “culture” of pain control: A review of opioid-induced dysbiosis (OID) in antinociceptive tolerance
RA Mischel, KH Muchhala, WL Dewey, HI Akbarali
The Journal of Pain 21 (7-8), 751-762, 2020
42020
The role of morphine-induced impairment of intestinal epithelial antibacterial activity in dysbiosis and its impact on the microbiota-gut-brain axis
K Muchhala, M Kang, E Koseli, J Poklis, Q Xu, W Dewey, J Fettweis, ...
Research Square, 2023
32023
Chronic Morphine Induces IL-18 in Ileum Myenteric Plexus Neurons Through Mu-opioid Receptor Activation in Cholinergic and VIPergic Neurons
KH Muchhala, E Koseli, AR Gade, K Woods, S Minai, M Kang, ...
Journal of Neuroimmune Pharmacology 17 (1-2), 111-130, 2022
32022
Rapid tolerance to morphine in the myenteric neurons of the small intestine is independent of β-arrestin-2 and mediated by PKC
KH Muchhala, JC Jacob, I Alam, S Hasan, A Khan, M Kang, WL Dewey, ...
BioRxiv, 2020.07. 17.209437, 2020
32020
Mutations In GABAA Receptor Loop 2 Create Ultrasensitive Ethanol Receptors (USERs) Sensitive To Micromolar Ethanol Concentrations
A Naito, K Muchhala, L Asatryan, JR Trudell, GE Homanics, DL Davies, ...
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH 37, 242A-242A, 2013
12013
Endocannabinoid biosynthetic enzymes regulate pain response via LKB1–AMPK signaling
M Chen, M Shin, TB Ware, G Donvito, KH Muchhala, R Mischel, ...
Proceedings of the National Academy of Sciences 120 (52), e2304900120, 2023
2023
Enhanced Cholinergic Action of Myenteric Neurons During Chemotherapy Induced Diarrhea
S Cheatham, KH Muchhala, HI Akbarali
Journal of Pharmacology and Experimental Therapeutics 385 (S3), 2023
2023
Chronic Morphine and Fentanyl Induce Intestinal Dysbiosis by Decreasing the Antimicrobial Activity of the Ileum
KH Muchhala, GK Mahon, E Koseli, J Bethea, M Kang, HI Akbarali
Journal of Pharmacology and Experimental Therapeutics 385 (S3), 368, 2023
2023
O-13: INHIBITION OF THE ENDOCANNABINOID REGULATING ENZYME MONOACYLGLYCEROL LIPASE AMELIORATES THE HYPER-NOCICEPTIVE PHENOTYPE IN THE BERKELEY MOUSE MODEL OF SICKLE CELL DISEASE
K GOLDSBOROUGH, K MUCHHALA, A ADU-GYAMFI, S HERZ, ...
HemaSphere 6 (Suppl), 2022
2022
Distinct Mechanisms of Morphine Tolerance in Enteric Neurons and Dorsal Root Ganglia Neurons: Role of β‐arrestin‐2
KH Muchhala, HI Akbarali
The FASEB Journal 36, 2022
2022
An investigation on the role of β-arrestin 2, protein kinase C and sex on the mechanism of morphine tolerance in the mouse ileum
KH Muchhala
2019
μ-Opioid Receptors Co-Expressed in Cholinergic Neurons of Mouse Ileum Myenteric Plexus Develop Tolerance to Chronic Morphine Exposure
K Muchhala, A Gade, WL Dewey, HI Akbarali
Gastroenterology 152 (5), S710, 2017
2017
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