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Lucas Farnung
Lucas Farnung
Assistant Professor of Cell Biology, Harvard Medical School
在 hms.harvard.edu 的电子邮件经过验证 - 首页
标题
引用次数
引用次数
年份
Structure of replicating SARS-CoV-2 polymerase
HS Hillen, G Kokic, L Farnung, C Dienemann, D Tegunov, P Cramer
Nature 584 (7819), 154-156, 2020
7892020
Mechanism of SARS-CoV-2 polymerase stalling by remdesivir
G Kokic, HS Hillen, D Tegunov, C Dienemann, F Seitz, J Schmitzova, ...
Nature communications 12 (1), 1-7, 2021
5762021
Structure of activated transcription complex Pol II–DSIF–PAF–SPT6
SM Vos, L Farnung, M Boehning, C Wigge, A Linden, H Urlaub, P Cramer
Nature 560 (7720), 607-612, 2018
3892018
Structure of paused transcription complex Pol II–DSIF–NELF
SM Vos, L Farnung, H Urlaub, P Cramer
Nature 560 (7720), 601-606, 2018
3492018
The interaction landscape between transcription factors and the nucleosome
F Zhu, L Farnung, E Kaasinen, B Sahu, Y Yin, B Wei, SO Dodonova, ...
Nature 562 (7725), 76-81, 2018
3312018
Nucleosome–Chd1 structure and implications for chromatin remodelling
L Farnung, SM Vos, C Wigge, P Cramer
Nature 550 (7677), 539-542, 2017
2442017
The structure and substrate specificity of human Cdk12/Cyclin K
CA Bösken, L Farnung, C Hintermair, M Merzel Schachter, ...
Nature communications 5 (1), 3505, 2014
1912014
Structure of complete Pol II–DSIF–PAF–SPT6 transcription complex reveals RTF1 allosteric activation
SM Vos, L Farnung, A Linden, H Urlaub, P Cramer
Nature Structural & Molecular Biology 27 (7), 668-677, 2020
1262020
Structure of transcribing RNA polymerase II-nucleosome complex
L Farnung, SM Vos, P Cramer
Nature communications 9 (1), 5432, 2018
1052018
Structural basis of nucleosome transcription mediated by Chd1 and FACT
L Farnung, M Ochmann, M Engeholm, P Cramer
Nature Structural & Molecular Biology 28 (4), 382-387, 2021
952021
Two distinct mechanisms of RNA polymerase II elongation stimulation in vivo
K Žumer, KC Maier, L Farnung, MG Jaeger, P Rus, G Winter, P Cramer
Molecular Cell 81 (15), 3096-3109. e8, 2021
782021
Nucleosome-CHD4 chromatin remodeller structure maps human disease mutations
L Farnung, M Ochmann, P Cramer
eLife 9, e56178, 2020
69*2020
Structure of H3K36-methylated nucleosome–PWWP complex reveals multivalent cross-gyre binding
H Wang, L Farnung, C Dienemann, P Cramer
Nature structural & molecular biology 27 (1), 8-13, 2020
692020
Ruler elements in chromatin remodelers set nucleosome array spacing and phasing
E Oberbeckmann, V Niebauer, S Watanabe, L Farnung, M Moldt, ...
Nature Communications 12 (1), 3232, 2021
602021
Structural basis of nucleosome retention during transcription elongation
M Filipovski, JHM Soffers, SM Vos, L Farnung
Science 376 (6599), 1313-1316, 2022
532022
Cryo-EM structure of a mammalian RNA polymerase II elongation complex inhibited by α-amanitin
X Liu, L Farnung, C Wigge, P Cramer
Journal of Biological Chemistry 293 (19), 7189-7194, 2018
452018
Structure of a backtracked hexasomal intermediate of nucleosome transcription
L Farnung, M Ochmann, G Garg, SM Vos, P Cramer
Molecular Cell 82 (17), 3126-3134. e7, 2022
432022
Assembly of RNA polymerase II transcription initiation complexes
L Farnung, SM Vos
Current opinion in structural biology 73, 102335, 2022
282022
Structural basis of sirtuin 6-catalyzed nucleosome deacetylation
ZA Wang, JW Markert, SD Whedon, M Yapa Abeywardana, K Lee, ...
Journal of the American Chemical Society 145 (12), 6811-6822, 2023
222023
Nucleosomal arrangement affects single-molecule transcription dynamics
V Fitz, J Shin, C Ehrlich, L Farnung, P Cramer, V Zaburdaev, SW Grill
Proceedings of the National Academy of Sciences 113 (45), 12733-12738, 2016
212016
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