Overcoming the challenges of solid bridging and constriction during Pd-Catalyzed C− N bond formation in microreactors RL Hartman, JR Naber, N Zaborenko, SL Buchwald, KF Jensen Organic Process Research & Development 14 (6), 1347-1357, 2010 | 274 | 2010 |
Accelerating reactions with microreactors at elevated temperatures and pressures: profiling aminocarbonylation reactions ER Murphy, JR Martinelli, N Zaborenko, SL Buchwald, KF Jensen Angewandte Chemie International Edition 46 (10), 1734-1737, 2007 | 271 | 2007 |
Development and scale-up of a continuous, high-pressure, asymmetric hydrogenation reaction, workup, and isolation MD Johnson, SA May, JR Calvin, J Remacle, JR Stout, WD Diseroad, ... Organic Process Research & Development 16 (5), 1017-1038, 2012 | 163 | 2012 |
Aminolysis of epoxides in a microreactor system: a continuous flow approach to β-amino alcohols MW Bedore, N Zaborenko, KF Jensen, TF Jamison Organic Process Research & Development 14 (2), 432-440, 2010 | 159 | 2010 |
Development of an automated microfluidic reaction platform for multidimensional screening: reaction discovery employing bicyclo [3.2. 1] octanoid scaffolds JR Goodell, JP McMullen, N Zaborenko, JR Maloney, CX Ho, KF Jensen, ... The Journal of organic chemistry 74 (16), 6169-6180, 2009 | 131 | 2009 |
Kinetic and scale-up investigations of epoxide aminolysis in microreactors at high temperatures and pressures N Zaborenko, MW Bedore, TF Jamison, KF Jensen Organic Process Research & Development 15 (1), 131-139, 2011 | 118 | 2011 |
First-Principles and Empirical Approaches to Predicting In Vitro Dissolution for Pharmaceutical Formulation and Process Development and for Product Release … N Zaborenko, Z Shi, CC Corredor, BM Smith-Goettler, L Zhang, ... The AAPS journal 21, 1-20, 2019 | 106 | 2019 |
Solder-based chip-to-tube and chip-to-chip packaging for microfluidic devices ER Murphy, T Inoue, HR Sahoo, N Zaborenko, KF Jensen Lab on a Chip 7 (10), 1309-1314, 2007 | 64 | 2007 |
Pilot-scale continuous production of LY2886721: amide formation and reactive crystallization CS Polster, KP Cole, CL Burcham, BM Campbell, AL Frederick, ... Organic Process Research & Development 18 (11), 1295-1309, 2014 | 56 | 2014 |
Synthesis and kinetics of highly energetic intermediates by micromixers: direct multistep synthesis of sodium nitrotetrazolate N Zaborenko, ER Murphy, JG Kralj, KF Jensen Industrial & engineering chemistry research 49 (9), 4132-4139, 2010 | 53 | 2010 |
Microfluidic assisted synthesis of hybrid Au–pd dumbbell-like nanostructures: Sequential addition of reagents and ultrasonic radiation V Sebastian, N Zaborenko, L Gu, KF Jensen Crystal Growth & Design 17 (5), 2700-2710, 2017 | 33 | 2017 |
Acetophenone hydrogenation on Rh/Al2O3 catalyst: Intrinsic reaction kinetics and effects of internal diffusion S Lee, Z Yu, N Zaborenko, A Varma Chemical Engineering Journal 288, 711-723, 2016 | 32 | 2016 |
Development of pilot-scale continuous production of an LY2886721 starting material by packed-bed hydrogenolysis N Zaborenko, RJ Linder, TM Braden, BM Campbell, MM Hansen, ... Organic Process Research & Development 19 (9), 1231-1243, 2015 | 31 | 2015 |
Synthesis of BACE inhibitor LY2886721. Part II. isoxazolidines as precursors to chiral aminothiazines, selective peptide coupling, and a controlled reactive crystallization MM Hansen, DJ Jarmer, E Arslantas, AC DeBaillie, AL Frederick, ... Organic Process Research & Development 19 (9), 1214-1230, 2015 | 29 | 2015 |
Acetophenone hydrogenation on Rh/Al2O3 catalyst: Flow regime effect and trickle bed reactor modeling S Lee, N Zaborenko, A Varma Chemical Engineering Journal 317, 42-50, 2017 | 14 | 2017 |
Methods for handling solids in microfluidic systems RL Hartman, JR Naber, N Zaborenko, JP McMullen, KF Jensen US Patent 8,763,623, 2014 | 12 | 2014 |
Continuous flow synthesis of amino alcohols using microreactors MW Bedore, N Zaborenko, KF Jensen, TF Jamison US Patent 8,877,930, 2014 | 11 | 2014 |
Latent variables-based process modeling of a continuous hydrogenation reaction in API synthesis of small molecules Z Shi, N Zaborenko, DE Reed Journal of Pharmaceutical Innovation 8, 1-10, 2013 | 10 | 2013 |
Continuous-flow study and scale-up of conventionally difficult chemical processes N Zaborenko Massachusetts Institute of Technology, 2010 | 3 | 2010 |
Dissolution Method Troubleshooting: An Industry Perspective J Mann, A Hermans, N Contrella, B Nickerson, CA Coutant, C Jede, S Kao, ... Dissolution technologies 29 (4), 190-203, 2022 | 1 | 2022 |