The mycobacterial transcriptional regulator whiB7 gene links redox homeostasis and intrinsic antibiotic resistance J Burian, S Ramón-García, G Sweet, A Gómez-Velasco, Y Av-Gay, ... Journal of Biological Chemistry 287 (1), 299-310, 2012 | 162 | 2012 |
The mycobacterial antibiotic resistance determinant WhiB7 acts as a transcriptional activator by binding the primary sigma factor SigA (RpoV) J Burian, G Yim, M Hsing, P Axerio-Cilies, A Cherkasov, GB Spiegelman, ... Nucleic acids research 41 (22), 10062-10076, 2013 | 114 | 2013 |
A system for the targeted amplification of bacterial gene clusters multiplies antibiotic yield in Streptomyces coelicolor T Murakami, J Burian, K Yanai, MJ Bibb, CJ Thompson Proceedings of the National Academy of Sciences 108 (38), 16020-16025, 2011 | 89 | 2011 |
WhiB7, a transcriptional activator that coordinates physiology with intrinsic drug resistance in Mycobacterium tuberculosis J Burian, S Ramon-Garcia, CG Howes, CJ Thompson Expert review of anti-infective therapy 10 (9), 1037-1047, 2012 | 74 | 2012 |
WhiB7, an Fe-S-dependent transcription factor that activates species-specific repertoires of drug resistance determinants in actinobacteria S Ramón-García, C Ng, PR Jensen, M Dosanjh, J Burian, RP Morris, ... Journal of Biological Chemistry 288 (48), 34514-34528, 2013 | 69 | 2013 |
Antagonism between Front-Line Antibiotics Clarithromycin and Amikacin in the Treatment of Mycobacterium abscessus Infections Is Mediated by the whiB7 Gene M Pryjma, J Burian, K Kuchinski, CJ Thompson Antimicrobial agents and chemotherapy 61 (11), 10.1128/aac. 01353-17, 2017 | 67 | 2017 |
Rifabutin acts in synergy and is bactericidal with frontline Mycobacterium abscessus antibiotics clarithromycin and tigecycline, suggesting a potent treatment combination M Pryjma, J Burian, CJ Thompson Antimicrobial agents and chemotherapy 62 (8), 10.1128/aac. 00283-18, 2018 | 51 | 2018 |
Regulatory genes coordinating antibiotic‐induced changes in promoter activity and early transcriptional termination of the mycobacterial intrinsic resistance gene whiB7 J Burian, CJ Thompson Molecular microbiology 107 (3), 402-415, 2018 | 30 | 2018 |
Multiplexed mobilization and expression of biosynthetic gene clusters V Libis, LW MacIntyre, R Mehmood, L Guerrero, MA Ternei, N Antonovsky, ... Nature Communications 13 (1), 5256, 2022 | 18 | 2022 |
High-throughput retrieval of target sequences from complex clone libraries using CRISPRi J Burian, VK Libis, YA Hernandez, L Guerrero-Porras, MA Ternei, ... Nature biotechnology 41 (5), 626-630, 2023 | 11 | 2023 |
Present and future outlooks on environmental DNA-based methods for antibiotic discovery AF Rosenzweig, J Burian, SF Brady Current opinion in microbiology 75, 102335, 2023 | 7 | 2023 |
DNA glycosylases provide antiviral defence in prokaryotes AA Hossain, YZ Pigli, CF Baca, S Heissel, A Thomas, VK Libis, J Burian, ... Nature, 1-7, 2024 | 4 | 2024 |
Research briefing J Burian, SF Brady Nature Biotechnology 41, 620-621, 2023 | | 2023 |
6.02 General Strategies for Biosynthetic Gene Cluster Identification, Capture, and Heterologous Expression J Burian, SF Brady Comprehensive Natural Products III: Chemistry and Biology, 3, 2020 | | 2020 |
Characterization of the transcriptional regulator WhiB7 establishes a link between metabolism and intrinsic antibiotic resistance in mycobacteria J Burian University of British Columbia, 2015 | | 2015 |
Insights into whiB7 activation and action J Burian, S Ramón-García, G Sweet, A Gómez-Velasco, Y Av-Gay, ... | | 2011 |
Lamichhane G Liu J Machado D Martins M H Morbidoni, H Boshoff, P Brennan, J Burian, R Buxton, K Chater, ... | | |