The crystal structure of the proprotein processing proteinase furin explains its stringent specificity S Henrich, A Cameron, GP Bourenkov, R Kiefersauer, R Huber, ... Nature Structural & Molecular Biology 10 (7), 520-526, 2003 | 435 | 2003 |
Disruption of PC1/3 expression in mice causes dwarfism and multiple neuroendocrine peptide processing defects X Zhu, A Zhou, A Dey, C Norrbom, R Carroll, C Zhang, V Laurent, ... Proceedings of the National Academy of Sciences 99 (16), 10293-10298, 2002 | 424 | 2002 |
Polyarginines are potent furin inhibitors A Cameron, J Appel, RA Houghten, I Lindberg Journal of Biological Chemistry 275 (47), 36741-36749, 2000 | 268 | 2000 |
Purification and characterization of the prohormone convertase PC1 (PC3). Y Zhou, I Lindberg Journal of Biological Chemistry 268 (8), 5615-5623, 1993 | 214 | 1993 |
The neuroendocrine protein 7B2 is required for peptide hormone processing in vivo and provides a novel mechanism for pituitary Cushing’s disease CH Westphal, L Muller, A Zhou, X Zhu, S Bonner-Weir, M Schambelan, ... Cell 96 (5), 689-700, 1999 | 210 | 1999 |
Proprotein convertase models based on the crystal structures of furin and kexin: explanation of their specificity S Henrich, I Lindberg, W Bode, ME Than Journal of molecular biology 345 (2), 211-227, 2005 | 197 | 2005 |
Prodynorphin processing by proprotein convertase 2: cleavage at single basic residues and enhanced processing in the presence of carboxypeptidase activity R Day, C Lazure, A Basak, A Boudreault, P Limperis, W Dong, I Lindberg Journal of Biological Chemistry 273 (2), 829-836, 1998 | 191 | 1998 |
The neuroendocrine polypeptide 7B2 is an endogenous inhibitor of prohormone convertase PC2. GJ Martens, JA Braks, DW Eib, Y Zhou, I Lindberg Proceedings of the National Academy of Sciences 91 (13), 5784-5787, 1994 | 181 | 1994 |
7B2 facilitates the maturation of proPC2 in neuroendocrine cells and is required for the expression of enzymatic activity. X Zhu, I Lindberg The Journal of cell biology 129 (6), 1641-1650, 1995 | 178 | 1995 |
Differential processing of proenkephalin by prohormone convertases 1 (3) and 2 and furin. MB Breslin, I Lindberg, S Benjannet, JP Mathis, C Lazure, NG Seidah Journal of Biological Chemistry 268 (36), 27084-27093, 1993 | 173 | 1993 |
The cell biology of the prohormone convertases PCI and PC2 L Muller, I Lindberg Progress in nucleic acid research and molecular biology 63, 69-108, 1999 | 164 | 1999 |
Congenital proprotein convertase 1/3 deficiency causes malabsorptive diarrhea and other endocrinopathies in a pediatric cohort MG Martín, I Lindberg, RS Solorzano–Vargas, J Wang, Y Avitzur, ... Gastroenterology 145 (1), 138-148, 2013 | 152 | 2013 |
Biosynthesis of the prohormone convertase mPC1 in AtT-20 cells. O Vindrola, I Lindberg Molecular Endocrinology 6 (7), 1088-1094, 1992 | 151 | 1992 |
Inhibition of furin by polyarginine-containing peptides: nanomolar inhibition by nona-D-arginine MM Kacprzak, JR Peinado, ME Than, J Appel, S Henrich, G Lipkind, ... Journal of Biological Chemistry 279 (35), 36788-36794, 2004 | 145 | 2004 |
Potent inhibitors of furin and furin-like proprotein convertases containing decarboxylated P1 arginine mimetics GL Becker, F Sielaff, ME Than, I Lindberg, S Routhier, R Day, Y Lu, ... Journal of medicinal chemistry 53 (3), 1067-1075, 2010 | 128 | 2010 |
Highly potent inhibitors of proprotein convertase furin as potential drugs for treatment of infectious diseases GL Becker, Y Lu, K Hardes, B Strehlow, C Levesque, I Lindberg, ... Journal of Biological Chemistry 287 (26), 21992-22003, 2012 | 126 | 2012 |
Specificity of prohormone convertase 2 on proenkephalin and proenkephalin-related substrates K Johanning, MA Juliano, L Juliano, C Lazure, NS Lamango, DF Steiner, ... Journal of Biological Chemistry 273 (35), 22672-22680, 1998 | 121 | 1998 |
Mechanism of the facilitation of PC2 maturation by 7B2: involvement in ProPC2 transport and activation but not folding L Muller, X Zhu, I Lindberg The Journal of cell biology 139 (3), 625-638, 1997 | 117 | 1997 |
Purification and enzymatic characterization of recombinant prohormone convertase 2: stabilization of activity by 21 kDa 7B2 NS Lamango, X Zhu, I Lindberg Archives of biochemistry and biophysics 330 (2), 238-250, 1996 | 110 | 1996 |
Cleavage targets and the D-arginine-based inhibitors of the West Nile virus NS3 processing proteinase SA Shiryaev, BI Ratnikov, AV Chekanov, S Sikora, DV Rozanov, A Godzik, ... Biochemical Journal 393 (2), 503-511, 2006 | 107 | 2006 |