| Aβ oligomers induce neuronal oxidative stress through an N-methyl-D-aspartate receptor-dependent mechanism that is blocked by the Alzheimer drug memantine FG De Felice, PT Velasco, MP Lambert, K Viola, SJ Fernandez, ... Journal of Biological Chemistry 282 (15), 11590-11601, 2007 | 1092 | 2007 |
| An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer’s disease–associated Aβ oligomers TR Bomfim, L Forny-Germano, LB Sathler, J Brito-Moreira, JC Houzel, ... The Journal of clinical investigation 122 (4), 1339-1353, 2012 | 919 | 2012 |
| Protection of synapses against Alzheimer's-linked toxins: insulin signaling prevents the pathogenic binding of Aβ oligomers FG De Felice, MNN Vieira, TR Bomfim, H Decker, PT Velasco, ... Proceedings of the National Academy of Sciences 106 (6), 1971-1976, 2009 | 779 | 2009 |
| Amyloid beta oligomers induce impairment of neuronal insulin receptors WQ Zhao, FG De Felice, S Fernandez, H Chen, MP Lambert, MJ Quon, ... The FASEB Journal 22 (1), 246-260, 2008 | 723 | 2008 |
| Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer’s models MV Lourenco, RL Frozza, GB de Freitas, H Zhang, GC Kincheski, ... Nature medicine 25 (1), 165-175, 2019 | 704 | 2019 |
| Alzheimer's disease-type neuronal tau hyperphosphorylation induced by Aβ oligomers FG De Felice, D Wu, MP Lambert, SJ Fernandez, PT Velasco, PN Lacor, ... Neurobiology of aging 29 (9), 1334-1347, 2008 | 613 | 2008 |
| Inflammation, defective insulin signaling, and mitochondrial dysfunction as common molecular denominators connecting type 2 diabetes to Alzheimer disease FG De Felice, ST Ferreira Diabetes 63 (7), 2262-2272, 2014 | 610 | 2014 |
| Intranasal insulin as a treatment for Alzheimer’s disease: a review of basic research and clinical evidence J Freiherr, M Hallschmid, WH Frey, YF Brünner, CD Chapman, ... CNS drugs 27, 505-514, 2013 | 540 | 2013 |
| Monoclonal antibodies that target pathological assemblies of Aβ MP Lambert, PT Velasco, L Chang, KL Viola, S Fernandez, PN Lacor, ... Journal of neurochemistry 100 (1), 23-35, 2007 | 439 | 2007 |
| Soluble amyloid-β oligomers as synaptotoxins leading to cognitive impairment in Alzheimer’s disease ST Ferreira, MV Lourenco, MM Oliveira, FG De Felice Frontiers in cellular neuroscience 9, 191, 2015 | 425 | 2015 |
| Inflammation, defective insulin signaling, and neuronal dysfunction in Alzheimer's disease ST Ferreira, JR Clarke, TR Bomfim, FG De Felice Alzheimer's & dementia 10 (1), S76-S83, 2014 | 420 | 2014 |
| How does brain insulin resistance develop in Alzheimer's disease? FG De Felice, MV Lourenco, ST Ferreira Alzheimer's & Dementia 10 (1), S26-S32, 2014 | 414 | 2014 |
| Soluble protein oligomers as emerging toxins in Alzheimer's and other amyloid diseases ST Ferreira, MNN Vieira, FG De Felice IUBMB life 59 (4‐5), 332-345, 2007 | 409 | 2007 |
| TNF-α mediates PKR-dependent memory impairment and brain IRS-1 inhibition induced by Alzheimer’s β-amyloid oligomers in mice and monkeys MV Lourenco, JR Clarke, RL Frozza, TR Bomfim, L Forny-Germano, ... Cell metabolism 18 (6), 831-843, 2013 | 399 | 2013 |
| Alzheimer’s disease and insulin resistance: translating basic science into clinical applications FG De Felice The Journal of clinical investigation 123 (2), 531-539, 2013 | 373 | 2013 |
| Mitochondrial bound hexokinase activity as a preventive antioxidant defense: steady-state ADP formation as a regulatory mechanism of membrane potential and reactive oxygen … WS da-Silva, A Gómez-Puyou, MT de Gómez-Puyou, R Moreno-Sanchez, ... Journal of Biological Chemistry 279 (38), 39846-39855, 2004 | 324 | 2004 |
| Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the central nervous system FG De Felice, F Tovar-Moll, J Moll, DP Munoz, ST Ferreira Trends in neurosciences 43 (6), 355-357, 2020 | 277 | 2020 |
| Mitochondrial creatine kinase activity prevents reactive oxygen species generation: antioxidant role of mitochondrial kinase-dependent ADP re-cycling activity LE Meyer, LB Machado, APSA Santiago, WS da-Silva, FG De Felice, ... Journal of Biological Chemistry 281 (49), 37361-37371, 2006 | 242 | 2006 |
| Alzheimer's disease-like pathology induced by amyloid-β oligomers in nonhuman primates L Forny-Germano, NML e Silva, AF Batista, J Brito-Moreira, M Gralle, ... Journal of Neuroscience 34 (41), 13629-13643, 2014 | 231 | 2014 |
| Targeting the neurotoxic species in Alzheimer's disease: inhibitors of Aβ oligomerization FG De Felice, MNN Vieira, LM Saraiva, JD Figueroa‐Villar, ... The FASEB journal 18 (12), 1366-1372, 2004 | 227 | 2004 |
