Generation of human induced pluripotent stem cells from dermal fibroblasts WE Lowry, L Richter, R Yachechko, AD Pyle, J Tchieu, R Sridharan, ... Proceedings of the National Academy of Sciences 105 (8), 2883-2888, 2008 | 1394 | 2008 |
Induced pluripotent stem cells and embryonic stem cells are distinguished by gene expression signatures MH Chin, MJ Mason, W Xie, S Volinia, M Singer, C Peterson, ... Cell stem cell 5 (1), 111-123, 2009 | 1241 | 2009 |
Proliferative neural stem cells have high endogenous ROS levels that regulate self-renewal and neurogenesis in a PI3K/Akt-dependant manner JE Le Belle, NM Orozco, AA Paucar, JP Saxe, J Mottahedeh, AD Pyle, ... Cell stem cell 8 (1), 59-71, 2011 | 811 | 2011 |
Defining the role of Wnt/β‐catenin signaling in the survival, proliferation, and self‐renewal of human embryonic stem cells G Dravid, Z Ye, H Hammond, G Chen, A Pyle, P Donovan, X Yu, L Cheng Stem cells 23 (10), 1489-1501, 2005 | 474 | 2005 |
A single CRISPR-Cas9 deletion strategy that targets the majority of DMD patients restores dystrophin function in hiPSC-derived muscle cells CS Young, MR Hicks, NV Ermolova, H Nakano, M Jan, S Younesi, ... Cell stem cell 18 (4), 533-540, 2016 | 411 | 2016 |
Female human iPSCs retain an inactive X chromosome J Tchieu, E Kuoy, MH Chin, H Trinh, M Patterson, SP Sherman, ... Cell stem cell 7 (3), 329-342, 2010 | 334 | 2010 |
Neurotrophins mediate human embryonic stem cell survival AD Pyle, LF Lock, PJ Donovan Nature biotechnology 24 (3), 344-350, 2006 | 329 | 2006 |
Specific loss of histone H3 lysine 9 trimethylation and HP1γ/cohesin binding at D4Z4 repeats is associated with facioscapulohumeral dystrophy (FSHD) W Zeng, JC De Greef, YY Chen, R Chien, X Kong, HC Gregson, ... PLoS genetics 5 (7), e1000559, 2009 | 320 | 2009 |
BRCA2 deficiency in mice leads to meiotic impairment and infertility SK Sharan, A Pyle, V Coppola, J Babus, S Swaminathan, J Benedict, ... Oxford University Press for The Company of Biologists Limited 131 (1), 131-142, 2004 | 235 | 2004 |
Increased lysis of stem cells but not their differentiated cells by natural killer cells; de-differentiation or reprogramming activates NK cells HC Tseng, A Arasteh, A Paranjpe, A Teruel, W Yang, A Behel, JA Alva, ... PloS one 5 (7), e11590, 2010 | 194 | 2010 |
Evidence for meiotic spindle checkpoint from analysis of spermatocytes from Robertsonian-chromosome heterozygous mice S Eaker, A Pyle, J Cobb, MA Handel Journal of Cell Science 114 (16), 2953-2965, 2001 | 173 | 2001 |
ERBB3 and NGFR mark a distinct skeletal muscle progenitor cell in human development and hPSCs MR Hicks, J Hiserodt, K Paras, W Fujiwara, A Eskin, M Jan, H Xi, ... Nature cell biology 20 (1), 46-57, 2018 | 168 | 2018 |
Involvement of lysosomal exocytosis in the excretion of mesoporous silica nanoparticles and enhancement of drug delivery effect by exocytosis inhibition RE Yanes, D Tarn, AA Hwang, DP Ferris, S Sherman, CR Thomas, J Lu, ... Small (Weinheim an der Bergstrasse, Germany) 9 (5), 697, 2013 | 168 | 2013 |
In vivo human somitogenesis guides somite development from hPSCs H Xi, W Fujiwara, K Gonzalez, M Jan, S Liebscher, B Van Handel, ... Cell reports 18 (6), 1573-1585, 2017 | 135 | 2017 |
Meiotic prophase abnormalities and metaphase cell death in MLH1-deficient mouse spermatocytes: insights into regulation of spermatogenic progress S Eaker, J Cobb, A Pyle, MA Handel Developmental biology 249 (1), 85-95, 2002 | 128 | 2002 |
A human skeletal muscle atlas identifies the trajectories of stem and progenitor cells across development and from human pluripotent stem cells H Xi, J Langerman, S Sabri, P Chien, CS Young, S Younesi, M Hicks, ... Cell stem cell 27 (1), 158-176. e10, 2020 | 123 | 2020 |
Creation of a novel humanized dystrophic mouse model of duchenne muscular dystrophy and application of a CRISPR/Cas9 gene editing therapy CS Young, E Mokhonova, M Quinonez, AD Pyle, MJ Spencer Journal of neuromuscular diseases 4 (2), 139-145, 2017 | 93 | 2017 |
Nucleofection mediates high-efficiency stable gene knockdown and transgene expression in human embryonic stem cells KA Hohenstein, AD Pyle, JY Chern, LF Lock, PJ Donovan Stem cells 26 (6), 1436-1443, 2008 | 86 | 2008 |
Copy number variant analysis of human embryonic stem cells H Wu, KJ Kim, K Mehta, S Paxia, A Sundstrom, T Anantharaman, ... Stem Cells 26 (6), 1484-1489, 2008 | 71 | 2008 |
Generation and characterization of transgene-free human induced pluripotent stem cells and conversion to putative clinical-grade status JP Awe, PC Lee, C Ramathal, A Vega-Crespo, J Durruthy-Durruthy, ... Stem cell research & therapy 4, 1-15, 2013 | 69 | 2013 |