关注
Yasuhiro Uno
Yasuhiro Uno
在 vet.kagoshima-u.ac.jp 的电子邮件经过验证
标题
引用次数
引用次数
年份
CYP2C76, a novel cytochrome P450 in cynomolgus monkey, is a major CYP2C in liver, metabolizing tolbutamide and testosterone
Y Uno, H Fujino, G Kito, T Kamataki, R Nagata
Molecular pharmacology 70 (2), 477-486, 2006
1242006
Macaque cytochromes P450: nomenclature, transcript, gene, genomic structure, and function
Y Uno, K Iwasaki, H Yamazaki, DR Nelson
Drug metabolism reviews 43 (3), 346-361, 2011
1152011
Utility of non-human primates in drug development: Comparison of non-human primate and human drug-metabolizing cytochrome P450 enzymes
Y Uno, S Uehara, H Yamazaki
Biochemical pharmacology 121, 1-7, 2016
762016
Ancient genome‐wide admixture extends beyond the current hybrid zone between Macaca fascicularis and M. mulatta
N Osada, Y Uno, K Mineta, Y Kameoka, I Takahashi, K Terao
Molecular Ecology 19 (14), 2884-2895, 2010
712010
Characterization of cynomolgus monkey cytochrome P450 (CYP) cDNAs: is CYP2C76 the only monkey-specific CYP gene responsible for species differences in drug metabolism?
Y Uno, S Hosaka, K Matsuno, C Nakamura, G Kito, T Kamataki, R Nagata
Archives of Biochemistry and Biophysics 466 (1), 98-105, 2007
712007
Cynomolgus monkey CYPs: a comparison with human CYPs
K Iwasaki, Y Uno
Xenobiotica 39 (8), 578-581, 2009
702009
Natural selection in the TLR-related genes in the course of primate evolution
T Nakajima, H Ohtani, Y Satta, Y Uno, H Akari, T Ishida, A Kimura
Immunogenetics 60, 727-735, 2008
662008
Genetic variants of CYP3A4 and CYP3A5 in cynomolgus and rhesus macaques
Y Uno, A Matsushita, N Osada, S Uehara, S Kohara, R Nagata, ...
Drug metabolism and disposition 38 (2), 209-214, 2010
612010
Immunochemical detection of cytochrome P450 enzymes in liver microsomes of 27 cynomolgus monkeys
S Uehara, N Murayama, Y Nakanishi, DC Zeldin, H Yamazaki, Y Uno
Journal of Pharmacology and Experimental Therapeutics 339 (2), 654-661, 2011
602011
Characterization of six base pair deletion in the putative HNF1-binding site of human PXR promoter
Y Uno, Y Sakamoto, K Yoshida, T Hasegawa, Y Hasegawa, T Koshino, ...
Journal of human genetics 48 (11), 594-597, 2003
532003
Large-scale analysis of Macaca fascicularis transcripts and inference of genetic divergence between M. fascicularis and M. mulatta
N Osada, K Hashimoto, Y Kameoka, M Hirata, R Tanuma, Y Uno, I Inoue, ...
BMC genomics 9, 1-15, 2008
482008
Drug oxygenation activities mediated by liver microsomal flavin-containing monooxygenases 1 and 3 in humans, monkeys, rats, and minipigs
M Yamazaki, M Shimizu, Y Uno, H Yamazaki
Biochemical pharmacology 90 (2), 159-165, 2014
472014
Human liver microsomal cytochrome P450 3A enzymes involved in thalidomide 5-hydroxylation and formation of a glutathione conjugate
G Chowdhury, N Murayama, Y Okada, Y Uno, M Shimizu, N Shibata, ...
Chemical research in toxicology 23 (6), 1018-1024, 2010
462010
CYP1D1, pseudogenized in human, is expressed and encodes a functional drug-metabolizing enzyme in cynomolgus monkey
Y Uno, S Uehara, N Murayama, H Yamazaki
Biochemical pharmacology 81 (3), 442-450, 2011
452011
CYP2C76-mediated species difference in drug metabolism: A comparison of pitavastatin metabolism between monkeys and humans
Y Uno, T Kumano, G Kito, R Nagata, T Kamataki, H Fujino
Xenobiotica 37 (1), 30-43, 2007
452007
Novel marmoset cytochrome P450 2C19 in livers efficiently metabolizes human P450 2C9 and 2C19 substrates, S-warfarin, tolbutamide, flurbiprofen, and omeprazole
S Uehara, Y Uno, T Inoue, M Kawano, M Shimizu, A Toda, M Utoh, ...
Drug metabolism and disposition 43 (10), 1408-1416, 2015
442015
Cynomolgus monkey CYP2D44 newly identified in liver, metabolizes bufuralol, and dextromethorphan
Y Uno, S Uehara, S Kohara, N Murayama, H Yamazaki
Drug Metabolism and Disposition 38 (9), 1486-1492, 2010
412010
A null allele impairs function of CYP2C76 gene in cynomolgus monkeys: a possible genetic tool for generation of a better animal model in drug metabolism
Y Uno, H Sakuraba, S Uehara, T Kumano, K Matsuno, C Nakamura, ...
Drug metabolism and disposition 37 (1), 14-17, 2009
402009
Pitavastatin as an in vivo probe for studying hepatic organic anion transporting polypeptide-mediated drug–drug interactions in cynomolgus monkeys
T Takahashi, T Ohtsuka, T Yoshikawa, I Tatekawa, Y Uno, M Utoh, ...
Drug Metabolism and Disposition 41 (10), 1875-1882, 2013
392013
Human plasma concentrations of cytochrome P450 probe cocktails extrapolated from pharmacokinetics in mice transplanted with human hepatocytes and from pharmacokinetics in …
M Utoh, H Suemizu, M Mitsui, M Kawano, A Toda, S Uehara, Y Uno, ...
Xenobiotica 46 (12), 1049-1055, 2016
372016
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