Small-molecule covalent modification of conserved cysteine leads to allosteric inhibition of the TEAD⋅ Yap protein-protein interaction K Bum-Erdene, D Zhou, G Gonzalez-Gutierrez, MK Ghozayel, Y Si, D Xu, ... Cell chemical biology 26 (3), 378-389. e13, 2019 | 149 | 2019 |
The Src homology 3 domain of the β-subunit of voltage-gated calcium channels promotes endocytosis via dynamin interaction G Gonzalez-Gutierrez, E Miranda-Laferte, A Neely, P Hidalgo Journal of Biological Chemistry 282 (4), 2156-2162, 2007 | 96 | 2007 |
Mutations that stabilize the open state of the Erwinia chrisanthemi ligand-gated ion channel fail to change the conformation of the pore domain in crystals G Gonzalez-Gutierrez, T Lukk, V Agarwal, D Papke, SK Nair, C Grosman Proceedings of the National Academy of Sciences 109 (16), 6331-6336, 2012 | 90 | 2012 |
Bridging the gap between structural models of nicotinic receptor superfamily ion channels and their corresponding functional states G Gonzalez-Gutierrez, C Grosman Journal of molecular biology 403 (5), 693-705, 2010 | 68 | 2010 |
The α1-β-subunit interaction that modulates calcium channel activity is reversible and requires a competent α-interaction domain P Hidalgo, G Gonzalez-Gutierrez, J Garcia-Olivares, A Neely Journal of Biological Chemistry 281 (34), 24104-24110, 2006 | 65 | 2006 |
Multi-metal restriction by calprotectin impacts de novo flavin biosynthesis in Acinetobacter baumannii J Wang, ZR Lonergan, G Gonzalez-Gutierrez, BL Nairn, CN Maxwell, ... Cell chemical biology 26 (5), 745-755. e7, 2019 | 64 | 2019 |
Gating of the proton-gated ion channel from Gloeobacter violaceus at pH 4 as revealed by X-ray crystallography G Gonzalez-Gutierrez, LG Cuello, SK Nair, C Grosman Proceedings of the National Academy of Sciences 110 (46), 18716-18721, 2013 | 53 | 2013 |
Homodimerization of the Src homology 3 domain of the calcium channel β-subunit drives dynamin-dependent endocytosis E Miranda-Laferte, G Gonzalez-Gutierrez, S Schmidt, A Zeug, ... Journal of Biological Chemistry 286 (25), 22203-22210, 2011 | 52 | 2011 |
Desensitization of neurotransmitter‐gated ion channels during high‐frequency stimulation: a comparative study of Cys‐loop, AMPA and purinergic receptors D Papke, G Gonzalez‐Gutierrez, C Grosman The Journal of physiology 589 (7), 1571-1585, 2011 | 47 | 2011 |
Small-molecule covalent bond formation at tyrosine creates a binding site and inhibits activation of Ral GTPases K Bum-Erdene, D Liu, G Gonzalez-Gutierrez, MK Ghozayel, D Xu, ... Proceedings of the National Academy of Sciences 117 (13), 7131-7139, 2020 | 34 | 2020 |
Structural basis for persulfide-sensing specificity in a transcriptional regulator DA Capdevila, BJC Walsh, Y Zhang, C Dietrich, G Gonzalez-Gutierrez, ... Nature chemical biology 17 (1), 65-70, 2021 | 33 | 2021 |
Chasing the open-state structure of pentameric ligand-gated ion channels G Gonzalez-Gutierrez, Y Wang, GD Cymes, E Tajkhorshid, C Grosman Journal of General Physiology 149 (12), 1119-1138, 2017 | 33 | 2017 |
The guanylate kinase domain of the β-subunit of voltage-gated calcium channels suffices to modulate gating G Gonzalez-Gutierrez, E Miranda-Laferte, D Nothmann, S Schmidt, ... Proceedings of the National Academy of Sciences 105 (37), 14198-14203, 2008 | 33 | 2008 |
Functional role of solvent entropy and conformational entropy of metal binding in a dynamically driven allosteric system DA Capdevila, KA Edmonds, GC Campanello, H Wu, ... Journal of the American Chemical Society 140 (29), 9108-9119, 2018 | 29 | 2018 |
The atypical cation-conduction and gating properties of ELIC underscore the marked functional versatility of the pentameric ligand-gated ion-channel fold G Gonzalez-Gutierrez, C Grosman Journal of General Physiology 146 (1), 15-36, 2015 | 20 | 2015 |
Discovery and structure of a widespread bacterial ABC transporter specific for ergothioneine Y Zhang, G Gonzalez-Gutierrez, KA Legg, BJC Walsh, CM Pis Diez, ... Nature Communications 13 (1), 7586, 2022 | 17 | 2022 |
Structural differences between the woodchuck hepatitis virus core protein in the dimer and capsid states are consistent with entropic and conformational regulation of assembly Z Zhao, JCY Wang, G Gonzalez-Gutierrez, B Venkatakrishnan, R Asor, ... Journal of virology 93 (14), 10.1128/jvi. 00141-19, 2019 | 17 | 2019 |
Slow Inactivation in Shaker K Channels Is Delayed by Intracellular Tetraethylammonium V González-Pérez, A Neely, C Tapia, G González-Gutiérrez, G Contreras, ... The Journal of general physiology 132 (6), 633-650, 2008 | 17 | 2008 |
Functional asymmetry and chemical reactivity of CsoR family persulfide sensors JN Fakhoury, Y Zhang, KA Edmonds, M Bringas, JL Luebke, ... Nucleic acids research 49 (21), 12556-12576, 2021 | 15 | 2021 |
Mutations of Nonconserved Residues within the Calcium Channel α1-interaction Domain Inhibit β-Subunit Potentiation G Gonzalez-Gutierrez, E Miranda-Laferte, D Naranjo, P Hidalgo, A Neely The Journal of general physiology 132 (3), 383-395, 2008 | 12 | 2008 |