[6]-Gingerol suppresses colon cancer growth by targeting leukotriene A4 hydrolase CH Jeong, AM Bode, A Pugliese, YY Cho, HG Kim, JH Shim, YJ Jeon, ... Cancer research 69 (13), 5584-5591, 2009 | 288 | 2009 |
Raf and MEK protein kinases are direct molecular targets for the chemopreventive effect of quercetin, a major flavonol in red wine KW Lee, NJ Kang, YS Heo, EA Rogozin, A Pugliese, MK Hwang, ... Cancer research 68 (3), 946-955, 2008 | 242 | 2008 |
Software and resources for computational medicinal chemistry C Liao, M Sitzmann, A Pugliese, MC Nicklaus Future medicinal chemistry 3 (8), 1057-1085, 2011 | 210 | 2011 |
Fragment-based hit identification: thinking in 3D AD Morley, A Pugliese, K Birchall, J Bower, P Brennan, N Brown, ... Drug Discovery Today 18 (23-24), 1221-1227, 2013 | 187 | 2013 |
Resveratrol, a Red Wine Polyphenol, Suppresses Pancreatic Cancer by Inhibiting Leukotriene A4 Hydrolase N Oi, CH Jeong, J Nadas, YY Cho, A Pugliese, AM Bode, Z Dong Cancer Research 70 (23), 9755-9764, 2010 | 124 | 2010 |
(-)-Epigallocatechin gallate regulates CD3-mediated T cell receptor signaling in leukemia through the inhibition of ZAP-70 kinase JH Shim, HS Choi, A Pugliese, SY Lee, JI Chae, BY Choi, AM Bode, ... Journal of Biological Chemistry 283 (42), 28370-28379, 2008 | 124 | 2008 |
A regulatory mechanism for RSK2 NH2-terminal kinase activity YY Cho, K Yao, A Pugliese, ML Malakhova, AM Bode, Z Dong Cancer research 69 (10), 4398-4406, 2009 | 78 | 2009 |
Computational tools and resources for metabolism-related property predictions. 1. Overview of publicly available (free and commercial) databases and software ML Peach, AV Zakharov, R Liu, A Pugliese, G Tawa, A Wallqvist, ... Future medicinal chemistry 4 (15), 1907-1932, 2012 | 68 | 2012 |
Eriodictyol inhibits RSK2-ATF1 signaling and suppresses EGF-induced neoplastic cell transformation K Liu, YY Cho, K Yao, J Nadas, DJ Kim, EJ Cho, MH Lee, A Pugliese, ... Journal of Biological Chemistry 286 (3), 2057-2066, 2011 | 68 | 2011 |
Cyclin-dependent kinase-3–mediated c-Jun phosphorylation at Ser63 and Ser73 enhances cell transformation YY Cho, F Tang, K Yao, C Lu, F Zhu, D Zheng, A Pugliese, AM Bode, ... Cancer research 69 (1), 272-281, 2009 | 61 | 2009 |
Role of NEK6 in tumor promoter-induced transformation in JB6 C141 mouse skin epidermal cells YJ Jeon, KY Lee, YY Cho, A Pugliese, HG Kim, CH Jeong, AM Bode, ... Journal of Biological Chemistry 285 (36), 28126-28133, 2010 | 46 | 2010 |
Herbacetin is a novel allosteric inhibitor of ornithine decarboxylase with antitumor activity DJ Kim, E Roh, MH Lee, N Oi, DY Lim, MO Kim, YY Cho, A Pugliese, ... Cancer research 76 (5), 1146-1157, 2016 | 41 | 2016 |
Anti-cancer gallotannin penta-O-galloyl-beta-D-glucose is a nanomolar inhibitor of select mammalian DNA polymerases Y Mizushina, J Zhang, A Pugliese, SH Kim, J Lü Biochemical pharmacology 80 (8), 1125-1132, 2010 | 39 | 2010 |
Structure-based design, synthesis and biological evaluation of a novel series of isoquinolone and pyrazolo [4, 3-c] pyridine inhibitors of fascin 1 as potential anti-metastatic … S Francis, D Croft, AW Schüttelkopf, C Parry, A Pugliese, K Cameron, ... Bioorganic & Medicinal Chemistry Letters 29 (8), 1023-1029, 2019 | 38 | 2019 |
Computational tools and resources for metabolism-related property predictions. 2. Application to prediction of half-life time in human liver microsomes AV Zakharov, ML Peach, M Sitzmann, IV Filippov, HJ McCartney, ... Future medicinal chemistry 4 (15), 1933-1944, 2012 | 35 | 2012 |
The resveratrol analogue 3, 5, 3′, 4′, 5′‐pentahydroxy‐trans‐stilbene inhibits cell transformation via MEK KW Lee, NJ Kang, EA Rogozin, SM Oh, YS Heo, A Pugliese, AM Bode, ... International journal of cancer 123 (11), 2487-2496, 2008 | 35 | 2008 |
Identification of a selective G1-phase benzimidazolone inhibitor by a senescence-targeted virtual screen using artificial neural networks AE Bilsland, A Pugliese, Y Liu, J Revie, S Burns, C McCormick, ... Neoplasia 17 (9), 704-715, 2015 | 22 | 2015 |
Automated generation of novel fragments using screening data, a dual SMILES autoencoder, transfer learning and syntax correction AE Bilsland, K McAulay, R West, A Pugliese, J Bower Journal of Chemical Information and Modeling 61 (6), 2547-2559, 2021 | 18 | 2021 |
Access to 3D Alicyclic Amine-Containing Fragments through Transannular C–H Arylation M Lee, A Adams, PB Cox, MS Sanford Synlett 30 (04), 417-422, 2019 | 17 | 2019 |
Stabilization of the ras: Pde6d complex is a novel strategy to inhibit ras signaling T Yelland, E Garcia, C Parry, D Kowalczyk, M Wojnowska, A Gohlke, ... Journal of Medicinal Chemistry 65 (3), 1898-1914, 2022 | 12 | 2022 |