| Adverse outcome pathways: opportunities, limitations and open questions M Leist, A Ghallab, R Graepel, R Marchan, R Hassan, SH Bennekou, ... Archives of Toxicology 91, 3477-3505, 2017 | 339 | 2017 |
| A distinct role for transient receptor potential ankyrin 1, in addition to transient receptor potential vanilloid 1, in tumor necrosis factor α–induced inflammatory … ES Fernandes, FA Russell, D Spina, JJ McDougall, R Graepel, C Gentry, ... Arthritis & Rheumatism 63 (3), 819-829, 2011 | 185 | 2011 |
| Evidence for the pathophysiological relevance of TRPA1 receptors in the cardiovascular system in vivo G Pozsgai, JV Bodkin, R Graepel, S Bevan, DA Andersson, SD Brain Cardiovascular research 87 (4), 760-768, 2010 | 145 | 2010 |
| Hydrogen peroxide is a novel mediator of inflammatory hyperalgesia, acting via transient receptor potential vanilloid 1-dependent and independent mechanisms JE Keeble, JV Bodkin, L Liang, R Wodarski, M Davies, ES Fernandes, ... Pain 141 (1), 135-142, 2009 | 126 | 2009 |
| Towards grouping concepts based on new approach methodologies in chemical hazard assessment: the read-across approach of the EU-ToxRisk project SE Escher, H Kamp, SH Bennekou, A Bitsch, C Fisher, R Graepel, ... Archives of toxicology 93, 3643-3667, 2019 | 122 | 2019 |
| TRPA1 is essential for the vascular response to environmental cold exposure AA Aubdool, R Graepel, X Kodji, KM Alawi, JV Bodkin, S Srivastava, ... Nature communications 5 (1), 5732, 2014 | 119 | 2014 |
| Alternative approaches for identifying acute systemic toxicity: Moving from research to regulatory testing J Hamm, K Sullivan, AJ Clippinger, J Strickland, S Bell, B Bhhatarai, ... Toxicology In Vitro 41, 245-259, 2017 | 73 | 2017 |
| A reactive oxygen species-mediated component in neurogenic vasodilatation A Starr, R Graepel, J Keeble, S Schmidhuber, N Clark, A Grant, AM Shah, ... Cardiovascular research 78 (1), 139-147, 2008 | 73 | 2008 |
| Alternative methods for regulatory toxicology–a state-of-the-art review A Worth, J Barroso, S Bremer, J Burton, S Casati, S Coecke, R Corvi, ... JRC Sci Policy Rep EUR 26797, 1-475, 2014 | 67 | 2014 |
| 4-oxo-2-nonenal (4-ONE): evidence of transient receptor potential ankyrin 1-dependent and-independent nociceptive and vasoactive responses in vivo R Graepel, ES Fernandes, AA Aubdool, DA Andersson, S Bevan, ... Journal of Pharmacology and Experimental Therapeutics 337 (1), 117-124, 2011 | 62 | 2011 |
| Splenic B cells from Hymenolepis diminuta–infected mice ameliorate colitis independent of T cells and via cooperation with macrophages JL Reyes, A Wang, MR Fernando, R Graepel, G Leung, N van Rooijen, ... The Journal of Immunology 194 (1), 364-378, 2015 | 56 | 2015 |
| Grouping of nanomaterials to read-across hazard endpoints: from data collection to assessment of the grouping hypothesis by application of chemoinformatic techniques L Lamon, D Asturiol, A Richarz, E Joossens, R Graepel, K Aschberger, ... Particle and fibre toxicology 15, 1-17, 2018 | 52 | 2018 |
| Murine autoimmune arthritis is exaggerated by infection with the rat tapeworm, Hymenolepis diminuta R Graepel, G Leung, A Wang, M Villemaire, FR Jirik, KA Sharkey, ... International journal for parasitology 43 (7), 593-601, 2013 | 38 | 2013 |
| Evaluation of the availability and applicability of computational approaches in the safety assessment of nanomaterials A Worth, K Aschberger, D Asturiol, J Bessems, K Gerloff, R Graepel, ... Publications Office of the European Union, Luxembourg 10, 248139, 2017 | 31 | 2017 |
| Indomethacin-induced translocation of bacteria across enteric epithelia is reactive oxygen species-dependent and reduced by vitamin C I Schoultz, CM McKay, R Graepel, VC Phan, A Wang, J Söderholm, ... American Journal of Physiology-Gastrointestinal and Liver Physiology 303 (5 …, 2012 | 31 | 2012 |
| Investigating cell type specific mechanisms contributing to acute oral toxicity P Prieto, R Graepel, K Gerloff, L Lamon, M Sachana, F Pistollato, ... ALTEX-Alternatives to animal experimentation 36 (1), 39-64, 2019 | 25 | 2019 |
| Involvement of Mast Cells in α7 Nicotinic Receptor Agonist Exacerbation of Freund's Complete Adjuvant–Induced Monoarthritis in Mice F Lopes, R Graepel, JL Reyes, A Wang, B Petri, JJ McDougall, ... Arthritis & Rheumatology 68 (2), 542-552, 2016 | 21 | 2016 |
| Integrate mechanistic evidence from new approach methodologies (NAMs) into a read-across assessment to characterise trends in shared mode of action SE Escher, A Aguayo-Orozco, E Benfenati, A Bitsch, T Braunbeck, ... Toxicology in Vitro 79, 105269, 2022 | 20 | 2022 |
| EURL ECVAM strategy to replace, reduce and refine the use of animals in the assessment of acute mammalian systemic toxicity P Prieto, J Burton, R Graepel, A Price, M Whelan, A Worth Publications Office of the European Union, Luxembourg, 2014 | 18 | 2014 |
| Paradigm shift in safety assessment using new approach methods: the EU-ToxRisk strategy R Graepel, B Ter Braak, SE Escher, C Fisher, I Gardner, H Kamp, ... Current Opinion in Toxicology 15, 33-39, 2019 | 14 | 2019 |
