LoFreq: a sequence-quality aware, ultra-sensitive variant caller for uncovering cell-population heterogeneity from high-throughput sequencing datasets A Wilm, PPK Aw, D Bertrand, GHT Yeo, SH Ong, CH Wong, CC Khor, ... Nucleic Acids Research, 2012 | 1239 | 2012 |
Spread, Circulation, and Evolution of the Middle East Respiratory Syndrome Coronavirus M Cotten, SJ Watson, AI Zumla, HQ Makhdoom, AL Palser, SH Ong, ... mBio 5 (1), e01062-13, 2014 | 287 | 2014 |
IVA: accurate de novo assembly of RNA virus genomes M Hunt, A Gall, SH Ong, J Brener, B Ferns, P Goulder, E Nastouli, ... Bioinformatics 31 (14), 2374-2376, 2015 | 207 | 2015 |
Spatial competition shapes the dynamic mutational landscape of normal esophageal epithelium B Colom, MP Alcolea, G Piedrafita, MWJ Hall, A Wabik, SC Dentro, ... Nature Genetics, 1-11, 2020 | 134 | 2020 |
Mutant clones in normal epithelium outcompete and eliminate emerging tumours B Colom, A Herms, MWJ Hall, SC Dentro, C King, RK Sood, MP Alcolea, ... Nature 598 (7881), 510-514, 2021 | 123 | 2021 |
Species Identification and Profiling of Complex Microbial Communities Using Shotgun Illumina Sequencing of 16S rRNA Amplicon Sequences SH Ong, VU Kukkillaya, A Wilm, C Lay, EXP Ho, L Low, ML Hibberd, ... PLOS ONE 8 (4), e60811, 2013 | 123 | 2013 |
Genomic epidemiology of a dengue virus epidemic in urban Singapore MJ Schreiber, EC Holmes, SH Ong, HSH Soh, W Liu, L Tanner, PPK Aw, ... Journal of Virology 83 (9), 4163-4173, 2009 | 121 | 2009 |
Outcompeting p53-mutant cells in the normal esophagus by redox manipulation D Fernandez-Antoran, G Piedrafita, K Murai, SH Ong, A Herms, C Frezza, ... Cell stem cell 25 (3), 329-341. e6, 2019 | 103 | 2019 |
A method for full genome sequencing of all four serotypes of the dengue virus JG Christenbury, PPK Aw, SH Ong, MJ Schreiber, A Chow, DJ Gubler, ... Journal of Virological Methods 169 (1), 202-206, 2010 | 98 | 2010 |
Deep sequencing of norovirus genomes defines evolutionary patterns in an urban tropical setting M Cotten, V Petrova, MVT Phan, MA Rabaa, SJ Watson, SH Ong, ... Journal of Virology 88 (19), 11056-11069, 2014 | 97 | 2014 |
Epidermal tissue adapts to restrain progenitors carrying clonal p53 mutations K Murai, G Skrupskelyte, G Piedrafita, M Hall, V Kostiou, SH Ong, T Nagy, ... Cell stem cell 23 (5), 687-699. e8, 2018 | 91 | 2018 |
Genome-wide CRISPR-KO Screen Uncovers mTORC1-Mediated Gsk3 Regulation in Naive Pluripotency Maintenance and Dissolution M Li, SL Jason, K Tilgner, SH Ong, H Koike-Yusa, K Yusa Cell Reports 24 (2), 489-502, 2018 | 87 | 2018 |
Plasmablasts Generated during Repeated Dengue Infection Are Virus Glycoprotein–Specific and Bind to Multiple Virus Serotypes MH Xu, V Hadinoto, R Appanna, K Joensson, YX Toh, T Balakrishnan, ... The Journal of Immunology 189 (12), 5877-5885, 2012 | 87 | 2012 |
Selection of oncogenic mutant clones in normal human skin varies with body site JC Fowler, C King, C Bryant, MWJ Hall, R Sood, SH Ong, E Earp, ... Cancer discovery 11 (2), 340-361, 2021 | 79 | 2021 |
Easy and accurate reconstruction of whole HIV genomes from short-read sequence data with shiver C Wymant, F Blanquart, T Golubchik, A Gall, M Bakker, D Bezemer, ... Virus Evolution 4 (1), vey007, 2018 | 78 | 2018 |
Periodic re-emergence of endemic strains with strong epidemic potential—A proposed explanation for the 2004 Indonesian dengue epidemic SH Ong, JT Yip, YL Chen, W Liu, S Harun, E Lystiyaningsih, B Heriyanto, ... Infection, Genetics and Evolution 8 (2), 191-204, 2008 | 69 | 2008 |
Viral genetic variation accounts for a third of variability in HIV-1 set-point viral load in Europe F Blanquart, C Wymant, M Cornelissen, A Gall, M Bakker, D Bezemer, ... PLoS biology 15 (6), e2001855, 2017 | 68 | 2017 |
A highly virulent variant of HIV-1 circulating in the Netherlands C Wymant, D Bezemer, F Blanquart, L Ferretti, A Gall, M Hall, T Golubchik, ... Science 375 (6580), 540-545, 2022 | 60 | 2022 |
Optimised metrics for CRISPR-KO screens with second-generation gRNA libraries SH Ong, Y Li, H Koike-Yusa, K Yusa Scientific Reports 7 (1), 7384, 2017 | 57 | 2017 |
Notch1 mutations drive clonal expansion in normal esophageal epithelium but impair tumor growth E Abby, SC Dentro, MWJ Hall, JC Fowler, SH Ong, R Sood, A Herms, ... Nature Genetics 55 (2), 232-245, 2023 | 53 | 2023 |