| VHL substrate transcription factor ZHX2 as an oncogenic driver in clear cell renal cell carcinoma J Zhang, T Wu, J Simon, M Takada, R Saito, C Fan, XD Liu, E Jonasch, ... Science 361 (6399), 290-295, 2018 | 145 | 2018 |
| TBK1 Is a Synthetic Lethal Target in Cancer with VHL Loss L Hu, H Xie, X Liu, F Potjewyd, LI James, EM Wilkerson, LE Herring, L Xie, ... Cancer discovery 10 (3), 460-475, 2020 | 82 | 2020 |
| FBW7 loss promotes chromosomal instability and tumorigenesis via cyclin E1/CDK2–mediated phosphorylation of CENP-A M Takada, W Zhang, A Suzuki, TS Kuroda, Z Yu, H Inuzuka, D Gao, ... Cancer research 77 (18), 4881-4893, 2017 | 77 | 2017 |
| Brahma is essential for Drosophila intestinal stem cell proliferation and regulated by Hippo signaling Y Jin, J Xu, MX Yin, Y Lu, L Hu, P Li, P Zhang, Z Yuan, MS Ho, H Ji, ... Elife 2, e00999, 2013 | 77 | 2013 |
| Genome-wide screening identifies SFMBT1 as an oncogenic driver in cancer with VHL loss X Liu, JM Simon, H Xie, L Hu, J Wang, G Zurlo, C Fan, TS Ptacek, ... Molecular cell 77 (6), 1294-1306. e5, 2020 | 50 | 2020 |
| Importin α1 mediates Yorkie nuclear import via an N-terminal non-canonical nuclear localization signal S Wang, Y Lu, MX Yin, C Wang, W Wu, J Li, W Wu, L Ge, L Hu, Y Zhao, ... Journal of Biological Chemistry 291 (15), 7926-7937, 2016 | 43 | 2016 |
| Identification of BBOX1 as a therapeutic target in triple-negative breast cancer C Liao, Y Zhang, C Fan, LE Herring, J Liu, JW Locasale, M Takada, ... Cancer discovery 10 (11), 1706-1721, 2020 | 38 | 2020 |
| Bantam is essential for Drosophila intestinal stem cell proliferation in response to Hippo signaling H Huang, J Li, L Hu, L Ge, H Ji, Y Zhao, L Zhang Developmental biology 385 (2), 211-219, 2014 | 35 | 2014 |
| USP37 promotes deubiquitination of HIF2α in kidney cancer K Hong, L Hu, X Liu, JM Simon, TS Ptacek, X Zheng, C Liao, AS Baldwin, ... Proceedings of the National Academy of Sciences 117 (23), 13023-13032, 2020 | 29 | 2020 |
| Histone H3 proline 16 hydroxylation regulates mammalian gene expression X Liu, J Wang, JA Boyer, W Gong, S Zhao, L Xie, Q Wu, C Zhang, K Jain, ... Nature genetics 54 (11), 1721-1735, 2022 | 28 | 2022 |
| An oncogenic JMJD6-DGAT1 axis tunes the epigenetic regulation of lipid droplet formation in clear cell renal cell carcinoma J Zhou, JM Simon, C Liao, C Zhang, L Hu, G Zurlo, X Liu, C Fan, ... Molecular cell 82 (16), 3030-3044. e8, 2022 | 24 | 2022 |
| Suppressor of Deltex mediates Pez degradation and modulates Drosophila midgut homeostasis C Wang, W Zhang, MX Yin, L Hu, P Li, J Xu, H Huang, S Wang, Y Lu, ... Nature Communications 6 (1), 6607, 2015 | 20 | 2015 |
| Ack promotes tissue growth via phosphorylation and suppression of the Hippo pathway component Expanded L Hu, J Xu, MX Yin, L Zhang, Y Lu, W Wu, Z Xue, MS Ho, G Gao, Y Zhao, ... Cell discovery 2 (1), 1-14, 2016 | 15 | 2016 |
| TBK1 is a synthetic lethal target in cancer with VHL loss. Cancer Discov. 2020; 10: 460–475. doi: 10.1158/2159-8290 L Hu, H Xie, X Liu, F Potjewyd, LI James, EM Wilkerson, LE Herring, L Xie, ... CD-19-0837.[Europe PMC free article][Abstract][CrossRef][Google Scholar], 0 | 9 | |
| Drosophila casein kinase 2 (CK2) promotes warts protein to suppress Yorkie protein activity for growth control L Hu, H Huang, J Li, MX Yin, Y Lu, W Wu, R Zeng, J Jiang, Y Zhao, ... Journal of Biological Chemistry 289 (48), 33598-33607, 2014 | 7 | 2014 |
| Von Hippel Lindau tumor suppressor controls m6A-dependent gene expression in renal tumorigenesis C Zhang, M Yu, AJ Hepperla, Z Zhang, R Raj, H Zhong, J Zhou, L Hu, ... Journal of Clinical Investigation 134 (8), e175703, 2024 | 1 | 2024 |
| Kinome-wide siRNA screen identifies a DCLK2-TBK1 oncogenic signaling axis in clear cell renal cell carcinoma L Hu, Y Zhang, L Guo, H Zhong, L Xie, J Zhou, C Liao, H Yao, J Fang, ... Molecular cell 84 (4), 776-790. e5, 2024 | 1 | 2024 |
| Von Hippel–Lindau protein signalling in clear cell renal cell carcinoma C Liao, L Hu, Q Zhang Nature Reviews Urology, 1-14, 2024 | | 2024 |
| Abstract PR007: Von Hippel Lindau (VHL) tumor suppressor regulates m6A-dependent gene expression involved in renal tumorigenesis C Zhang, Z Zhang, A Hepperla, M Yu, J Zhou, L Hu, J Fang, Q Liang, K Xu, ... Cancer Research 83 (16_Supplement), PR007-PR007, 2023 | | 2023 |
| Abstract A003: Kinome-wide siRNA screening identifies DCLK2 as a TBK1 activator and therapeutic target for ccRCC L Hu, Q Zhang Cancer Research 83 (16_Supplement), A003-A003, 2023 | | 2023 |
