Parkinson's disease: alterations in iron and redox biology as a key to unlock therapeutic strategies L Ma, MG Azad, M Dharmasivam, V Richardson, RJ Quinn, Y Feng, ... Redox biology 41, 101896, 2021 | 87 | 2021 |
The oncogenic signaling disruptor, NDRG1: molecular and cellular mechanisms of activity J Chekmarev, MG Azad, DR Richardson Cells 10 (9), 2382, 2021 | 41 | 2021 |
Designing tailored thiosemicarbazones with bespoke properties: The styrene moiety imparts potent activity, inhibits heme center oxidation, and results in a novel “Stealth Zinc … M Dharmasivam, B Kaya, T Wijesinghe, M Gholam Azad, MA Gonzalvez, ... Journal of Medicinal Chemistry 66 (2), 1426-1453, 2023 | 15 | 2023 |
The thiosemicarbazone, DpC, broadly synergizes with multiple anti-cancer therapeutics and demonstrates temperature-and energy-dependent uptake by tumor cells M Dharmasivam, MG Azad, R Afroz, V Richardson, PJ Jansson, ... Biochimica et Biophysica Acta (BBA)-General Subjects 1866 (8), 130152, 2022 | 15 | 2022 |
Ascorbate-and iron-driven redox activity of Dp44mT and Emodin facilitates peroxidation of micelles and bicelles OY Selyutina, PA Kononova, VE Koshman, EA Shelepova, MG Azad, ... Biochimica et Biophysica Acta (BBA)-General Subjects 1866 (4), 130078, 2022 | 11 | 2022 |
Calcium channels and iron metabolism: A redox catastrophe in Parkinson's disease and an innovative path to novel therapies? MK Boag, L Ma, GD Mellick, DL Pountney, Y Feng, RJ Quinn, AWC Liew, ... Redox Biology 47, 102136, 2021 | 7 | 2021 |
The Relationship of Glutathione-S-Transferase and Multi-Drug Resistance-Related Protein 1 in Nitric Oxide (NO) Transport and Storage TM Russell, MG Azad, DR Richardson Molecules 26 (19), 5784, 2021 | 7 | 2021 |
Innovative thiosemicarbazones that induce multi-modal mechanisms to down-regulate estrogen-, progesterone-, androgen-and prolactin-receptors in breast cancer F Shehadeh-Tout, HH Milioli, S Roslan, PJ Jansson, M Dharmasivam, ... Pharmacological Research 193, 106806, 2023 | 5 | 2023 |
Parkinson’s disease: alterations in iron and redox biology as a key to unlock therapeutic strategies. Redox Biol 41: 101896 L Ma, M Gholam Azad, M Dharmasivam, V Richardson, RJ Quinn, Y Feng, ... | 5 | 2021 |
Ascorbate and tumor cell iron metabolism: The evolving story and its link to pathology DH Bae, M Gholam Azad, DS Kalinowski, DJR Lane, PJ Jansson, ... Antioxidants & Redox Signaling 33 (12), 816-838, 2020 | 5 | 2020 |
Steric Blockade of Oxy-Myoglobin Oxidation by Thiosemicarbazones: Structure–Activity Relationships of the Novel PPP4pT Series TP Wijesinghe, B Kaya, MA Gonzálvez, JR Harmer, M Gholam Azad, ... Journal of Medicinal Chemistry 66 (22), 15453-15476, 2023 | 4 | 2023 |
Differential transmetallation of complexes of the anti-cancer thiosemicarbazone, Dp4e4mT: effects on anti-proliferative efficacy, redox activity, oxy-myoglobin and oxy … M Dharmasivam, B Kaya, TP Wijesinghe, V Richardson, JR Harmer, ... Chemical Science 15 (3), 974-990, 2024 | 3 | 2024 |
An innovative non-hormonal strategy targeting redox active metals to down-regulate estrogen-, progesterone-, androgen-and prolactin-receptors in breast cancer F Shehadeh-Tout, HH Milioli, S Roslan, PJ Jansson, M Dharmasivam, ... bioRxiv, 2023.02. 02.526543, 2023 | 3 | 2023 |
Thiosemicarbazones reprogram pancreatic cancer bidirectional oncogenic signaling between cancer cells and stellate cells to suppress desmoplasia DR Richardson, MG Azad, R Afroz, V Richardson, M Dharmasivam Future Medicinal Chemistry 14 (13), 1005-1017, 2022 | 2 | 2022 |
Melanotransferrin Functions as a Pro-Oncogenic WNT Agonist: A Yin-Yang Relationship in Melanoma with the WNT Antagonist and Metastasis Suppressor, NDRG1 J Paluncic, M Gholam Azad, DJR Lane, J Skoda, KC Park, S Chiang, ... bioRxiv, 2023.02. 27.530353, 2023 | 1 | 2023 |
Isosteric Replacement of Sulfur to Selenium in a Thiosemicarbazone: Promotion of Zn (II) Complex Dissociation and Transmetalation to Augment Anticancer Efficacy B Kaya, M Gholam Azad, M Suleymanoglu, JR Harmer, TP Wijesinghe, ... Journal of Medicinal Chemistry, 2024 | | 2024 |
Multi-modal mechanisms of the metastasis suppressor, NDRG1: Inhibition of WNT/β-catenin signaling by stabilization of protein kinase Cα MG Azad, M Hussaini, TM Russell, V Richardson, B Kaya, ... Journal of Biological Chemistry, 107417, 2024 | | 2024 |
Correction to “Steric Blockade of Oxy-Myoglobin Oxidation by Thiosemicarbazones: Structure–Activity Relationships of the Novel PPP4pT Series’’ TP Wijesinghe, B Kaya, MA Gonzálvez, JR Harmer, M Gholam Azad, ... Journal of Medicinal Chemistry 67 (8), 6893-6893, 2024 | | 2024 |
Steric Blockade of Oxy-Myoglobin Oxidation by Thiosemicarbazones: Structure-Activity Relationships of the Novel PPP4pT Series (Vol 66, pg 15453, 2023) TP Wijesinghe, B Kaya, MA Gonzalvez, JR Harmer, M Gholam Azad, ... JOURNAL OF MEDICINAL CHEMISTRY, 2024 | | 2024 |