Conformational and dynamic plasticity in substrate-binding proteins underlies selective transport in ABC importers M de Boer, G Gouridis, R Vietrov, SL Begg, GK Schuurman-Wolters, ... Elife 8, e44652, 2019 | 113 | 2019 |
HDAC1-3 inhibitor MS-275 enhances IL10 expression in RAW264.7 macrophages and reduces cigarette smoke-induced airway inflammation in mice NGJ Leus, T van den Bosch, PE van der Wouden, K Krist, ME Ourailidou, ... Scientific reports 7 (1), 45047, 2017 | 73 | 2017 |
Rational Development of a Potent 15-Lipoxygenase-1 Inhibitor with in Vitro and ex Vivo Anti-inflammatory Properties N Eleftheriadis, CG Neochoritis, NGJ Leus, PE van der Wouden, ... Journal of medicinal chemistry 58 (19), 7850-7862, 2015 | 57 | 2015 |
Discovery of a novel activator of 5-lipoxygenase from an anacardic acid derived compound collection R Wisastra, PAM Kok, N Eleftheriadis, MP Baumgartner, CJ Camacho, ... Bioorganic & medicinal chemistry 21 (24), 7763-7778, 2013 | 42 | 2013 |
Design of a novel thiophene inhibitor of 15-lipoxygenase-1 with both anti-inflammatory and neuroprotective properties N Eleftheriadis, H Poelman, NGJ Leus, B Honrath, CG Neochoritis, ... European journal of medicinal chemistry 122, 786-801, 2016 | 39 | 2016 |
One-pot microwave assisted synthesis of new 2-alkoxycarbonylmethylene-4-oxo-1, 5-benzo-, naphtho-, and pyridodiazepines and assessment of their cytogenetic activity N Eleftheriadis, CG Neochoritis, CA Tsoleridis, ... European journal of medicinal chemistry 67, 302-309, 2013 | 37 | 2013 |
Identification of 6-benzyloxysalicylates as a novel class of inhibitors of 15-lipoxygenase-1 N Eleftheriadis, S Thee, J Te Biesebeek, P van der Wouden, BJ Baas, ... European Journal of Medicinal Chemistry 94, 265-275, 2015 | 34 | 2015 |
On the impact of competing intra-and intermolecular triplet-state quenching on photobleaching and photoswitching kinetics of organic fluorophores JH Smit, JHM van der Velde, J Huang, V Trauschke, SS Henrikus, S Chen, ... Physical Chemistry Chemical Physics 21 (7), 3721-3733, 2019 | 33 | 2019 |
Small multitarget molecules incorporating the enone moiety T Liargkova, N Eleftheriadis, F Dekker, E Voulgari, C Avgoustakis, ... Molecules 24 (1), 199, 2019 | 20 | 2019 |
Discovery of chromenes as inhibitors of macrophage migration inhibitory factor T Kok, H Wapenaar, K Wang, CG Neochoritis, T Zarganes-Tzitzikas, ... Bioorganic & medicinal chemistry 26 (5), 999-1005, 2018 | 20 | 2018 |
A nexus of intrinsic dynamics underlies translocase priming S Krishnamurthy, N Eleftheriadis, K Karathanou, JH Smit, AG Portaliou, ... Structure 29 (8), 846-858. e7, 2021 | 18 | 2021 |
A combinatorial approach for the discovery of drug-like inhibitors of 15-lipoxygenase-1 R van der Vlag, H Guo, U Hapko, N Eleftheriadis, L Monjas, FJ Dekker, ... European journal of medicinal chemistry 174, 45-55, 2019 | 18 | 2019 |
Ruthenium complexes as inhibitors of 15-lipoxygenase-1 K Traven, N Eleftheriadis, S Seršen, J Kljun, J Bezenšek, B Stanovnik, ... Polyhedron 101, 306-313, 2015 | 18 | 2015 |
Activity‐Based Probes for 15‐Lipoxygenase‐1 N Eleftheriadis, SA Thee, MRH Zwinderman, NGJ Leus, FJ Dekker Angewandte Chemie International Edition 55 (40), 12300-12305, 2016 | 17 | 2016 |
Identification of potential antivirulence agents by substitution-oriented screening for inhibitors of Streptococcus pyogenes sortase A M Wójcik, N Eleftheriadis, MRH Zwinderman, ASS Dömling, FJ Dekker, ... European Journal of Medicinal Chemistry 161, 93-100, 2019 | 16 | 2019 |
A thorough study on the reaction of DMAD with 1-arylaminoimidazole-2-thiones. Expeditious synthesis of imidazo [2, 1-b][1, 3] thiazoles through a novel arylamino rearrangement C Neochoritis, N Eleftheriadis, CA Tsoleridis, J Stephanidou-Stephanatou Tetrahedron 66 (3), 709-714, 2010 | 16 | 2010 |
Structural dynamics in the evolution of a bilobed protein scaffold G Gouridis, YA Muthahari, M de Boer, DA Griffith, A Tsirigotaki, K Tassis, ... Proceedings of the National Academy of Sciences 118 (49), e2026165118, 2021 | 15 | 2021 |
A Trap-Door Mechanism for Zinc Acquisition by Streptococcus pneumoniae AdcA Z Luo, JR Morey, E Deplazes, A Motygullina, A Tan, K Ganio, SL Neville, ... MBio 12 (1), 10.1128/mbio. 01958-20, 2021 | 12 | 2021 |
Preproteins couple the intrinsic dynamics of SecA to its ATPase cycle to translocate via a catch and release mechanism S Krishnamurthy, MF Sardis, N Eleftheriadis, KE Chatzi, JH Smit, ... Cell reports 38 (6), 2022 | 10 | 2022 |
Photoactivation provides a mechanistic explanation for pan-assay interference behaviour of 2-aminopyrroles in lipoxygenase inhibition H Guo, N Eleftheriadis, N Rohr-Udilova, A Dömling, FJ Dekker European Journal of Medicinal Chemistry 139, 633-643, 2017 | 10 | 2017 |