Bax crystal structures reveal how BH3 domains activate Bax and nucleate its oligomerization to induce apoptosis PE Czabotar, D Westphal, G Dewson, S Ma, C Hockings, WD Fairlie, ... Cell 152 (3), 519-531, 2013 | 648 | 2013 |
Bax dimerizes via a symmetric BH3: groove interface during apoptosis G Dewson, S Ma, P Frederick, C Hockings, I Tan, T Kratina, RM Kluck Cell Death & Differentiation 19 (4), 661-670, 2012 | 209 | 2012 |
VDAC2 enables BAX to mediate apoptosis and limit tumor development HS Chin, MX Li, IKL Tan, RL Ninnis, B Reljic, K Scicluna, LF Dagley, ... Nature communications 9 (1), 4976, 2018 | 142 | 2018 |
Bid chimeras indicate that most BH3-only proteins can directly activate Bak and Bax, and show no preference for Bak versus Bax C Hockings, K Anwari, RL Ninnis, J Brouwer, M O'Hely, M Evangelista, ... Cell death & disease 6 (4), e1735-e1735, 2015 | 98 | 2015 |
Assembly of the Bak apoptotic pore: a critical role for the Bak protein α6 helix in the multimerization of homodimers during apoptosis S Ma, C Hockings, K Anwari, T Kratina, S Fennell, M Lazarou, MT Ryan, ... Journal of Biological Chemistry 288 (36), 26027-26038, 2013 | 84 | 2013 |
A highly porous metal-organic framework system to deliver payloads for gene knockdown MH Teplensky, M Fantham, C Poudel, C Hockings, M Lu, A Guna, ... Chem 5 (11), 2926-2941, 2019 | 83 | 2019 |
Mcl-1 and Bcl-xL sequestration of Bak confers differential resistance to BH3-only proteins C Hockings, AE Alsop, SC Fennell, EF Lee, WD Fairlie, G Dewson, ... Cell Death & Differentiation 25 (4), 721-734, 2018 | 58 | 2018 |
Physiological restraint of Bak by Bcl-xL is essential for cell survival EF Lee, S Grabow, S Chappaz, G Dewson, C Hockings, RM Kluck, ... Genes & development 30 (10), 1240-1250, 2016 | 56 | 2016 |
BAK α6 permits activation by BH3-only proteins and homooligomerization via the canonical hydrophobic groove MX Li, IKL Tan, SB Ma, C Hockings, T Kratina, MA Dengler, AE Alsop, ... Proceedings of the National Academy of Sciences 114 (29), 7629-7634, 2017 | 41 | 2017 |
Satellite repeat transcripts modulate heterochromatin condensates and safeguard chromosome stability in mouse embryonic stem cells CL Novo, EV Wong, C Hockings, C Poudel, E Sheekey, M Wiese, ... Nature communications 13 (1), 3525, 2022 | 39 | 2022 |
Intramitochondrial proteostasis is directly coupled to α-synuclein and amyloid β1-42 pathologies J Lautenschläger, S Wagner-Valladolid, AD Stephens, ... Journal of Biological Chemistry 295 (30), 10138-10152, 2020 | 34 | 2020 |
A waveguide imaging platform for live‐cell TIRF imaging of neurons over large fields of view IS Opstad, F Ströhl, M Fantham, C Hockings, O Vanderpoorten, ... Journal of Biophotonics 13 (6), e201960222, 2020 | 19 | 2020 |
Endoplasmic Reticulum morphological regulation by RTN4/NOGO modulates neuronal regeneration by curbing luminal transport T Konno, P Parutto, DMD Bailey, V Davì, C Crapart, MA Awadelkareem, ... bioRxiv, 2021.05. 10.441946, 2021 | 13 | 2021 |
Discovery of an exosite on the SOCS2-SH2 domain that enhances SH2 binding to phosphorylated ligands EM Linossi, K Li, G Veggiani, C Tan, F Dehkhoda, C Hockings, DJ Calleja, ... Nature Communications 12 (1), 7032, 2021 | 12 | 2021 |
Compatibility of RUNX1/ETO fusion protein modules driving CD34+ human progenitor cell expansion L Chen-Wichmann, M Shvartsman, C Preiss, C Hockings, R Windisch, ... Oncogene 38 (2), 261-272, 2019 | 6 | 2019 |
Illuminating chromatin compaction in live cells and fixed tissues using SiR-DNA fluorescence lifetime C Hockings, C Poudel, KA Feeney, CL Novo, MS Hamouda, I Mela, ... BioRxiv, 2020.05. 02.073536, 2020 | 5 | 2020 |
Avoiding adsorption of Bcl-2 proteins to plasticware is important for accurate quantitation C Hockings, S Iyer, RT Uren, RM Kluck Cell Death & Differentiation 26 (5), 794-795, 2019 | 2 | 2019 |
BAX requires VDAC2 to mediate apoptosis and to limit tumor development HS Chin, MF van Delft, RL Ninnis, MX Li, IKL Tan, B Reljic, K Scicluna, ... BioRxiv, 266668, 2018 | 1 | 2018 |
Endoplasmic reticulum morphology regulation by RTN4 modulates neuronal regeneration by curbing luminal transport T Konno, P Parutto, CC Crapart, V Davì, DMD Bailey, MA Awadelkareem, ... Cell Reports 43 (7), 2024 | | 2024 |
Discovery of an exosite on the SOCS2-SH2 domain that enhances SH2 binding to phosphorylated ligands (vol 4, 7951, 2023) EM Linossi, K Li, G Veggiani, C Tan, F Dehkhoda, C Hockings, DJ Calleja, ... NATURE COMMUNICATIONS 14 (1), 2023 | | 2023 |