| Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating … P Godoy, NJ Hewitt, U Albrecht, ME Andersen, N Ansari, S Bhattacharya, ... Archives of toxicology 87, 1315-1530, 2013 | 1428 | 2013 |
| Biomarkers for drug-induced renal damage and nephrotoxicity—an overview for applied toxicology TC Fuchs, P Hewitt The AAPS journal 13, 615-631, 2011 | 233 | 2011 |
| Evaluation of a urinary kidney biomarker panel in rat models of acute and subchronic nephrotoxicity D Hoffmann, TC Fuchs, T Henzler, KA Matheis, T Herget, W Dekant, ... Toxicology 277 (1-3), 49-58, 2010 | 198 | 2010 |
| Application of integrated transcriptomic, proteomic and metabolomic profiling for the delineation of mechanisms of drug induced cell stress A Wilmes, A Limonciel, L Aschauer, K Moenks, C Bielow, MO Leonard, ... Journal of proteomics 79, 180-194, 2013 | 195 | 2013 |
| Managing the challenge of drug-induced liver injury: a roadmap for the development and deployment of preclinical predictive models RJ Weaver, EA Blomme, AE Chadwick, IM Copple, HHJ Gerets, ... Nature Reviews Drug Discovery 19 (2), 131-148, 2020 | 193 | 2020 |
| Human-induced pluripotent stem cells generate light responsive retinal organoids with variable and nutrient-dependent efficiency D Hallam, G Hilgen, B Dorgau, L Zhu, M Yu, S Bojic, P Hewitt, M Schmitt, ... Stem cells 36 (10), 1535-1551, 2018 | 173 | 2018 |
| Acute hepatotoxicity: a predictive model based on focused illumina microarrays N Zidek, J Hellmann, PJ Kramer, PG Hewitt Toxicological Sciences 99 (1), 289-302, 2007 | 130 | 2007 |
| Performance of novel kidney biomarkers in preclinical toxicity studies D Hoffmann, M Adler, VS Vaidya, E Rached, L Mulrane, WM Gallagher, ... Toxicological Sciences 116 (1), 8-22, 2010 | 125 | 2010 |
| Liver microphysiological systems development guidelines for safety risk assessment in the pharmaceutical industry AR Baudy, MA Otieno, P Hewitt, J Gan, A Roth, D Keller, R Sura, ... Lab on a Chip 20 (2), 215-225, 2020 | 115 | 2020 |
| Serum-free collagen sandwich cultures of adult rat hepatocytes maintain liver-like properties long term: a valuable model for in vitro toxicity and drug–drug interaction studies G Tuschl, J Hrach, Y Walter, PG Hewitt, SO Mueller Chemico-biological interactions 181 (1), 124-137, 2009 | 110 | 2009 |
| A multicenter assessment of single-cell models aligned to standard measures of cell health for prediction of acute hepatotoxicity RL Sison-Young, VM Lauschke, E Johann, E Alexandre, S Antherieu, ... Archives of toxicology 91, 1385-1400, 2017 | 106 | 2017 |
| Comparative proteomic characterization of 4 human liver-derived single cell culture models reveals significant variation in the capacity for drug disposition, bioactivation … RLC Sison-Young, D Mitsa, RE Jenkins, D Mottram, E Alexandre, ... Toxicological Sciences 147 (2), 412-424, 2015 | 101 | 2015 |
| In vivo bioavailability and metabolism of topical diclofenac lotion in human volunteers X Hui, PG Hewitt, N Poblete, HI Maibach, JZ Shainhouse, RC Wester Pharmaceutical research 15, 1589-1595, 1998 | 99 | 1998 |
| Delineation of the key aspects in the regulation of epithelial monolayer formation L Aschauer, LN Gruber, W Pfaller, A Limonciel, TJ Athersuch, R Cavill, ... Molecular and cellular biology 33 (13), 2535-2550, 2013 | 93 | 2013 |
| The evolving role of investigative toxicology in the pharmaceutical industry F Pognan, M Beilmann, H Boonen, A Czich, G Dear, P Hewitt, T Mow, ... Nature reviews drug discovery 22 (4), 317-335, 2023 | 89 | 2023 |
| Evaluation of novel acute urinary rat kidney toxicity biomarker for subacute toxicity studies in preclinical trials TC Fuchs, K Frick, B Emde, S Czasch, F Landenberg, P Hewitt Toxicologic pathology 40 (7), 1031-1048, 2012 | 83 | 2012 |
| Evidence-based selection of training compounds for use in the mechanism-based integrated prediction of drug-induced liver injury in man S Dragovic, NPE Vermeulen, HH Gerets, PG Hewitt, ... Archives of toxicology 90, 2979-3003, 2016 | 72 | 2016 |
| Application of RPTEC/TERT1 cells for investigation of repeat dose nephrotoxicity: a transcriptomic study L Aschauer, A Limonciel, A Wilmes, S Stanzel, A Kopp-Schneider, ... Toxicology in Vitro 30 (1), 106-116, 2015 | 69 | 2015 |
| Template for the description of cell-based toxicological test methods to allow evaluation and regulatory use of the data A Krebs, T Waldmann, MF Wilks, BMA van Vugt-Lussenburg, ... ALTEX-Alternatives to animal experimentation 36 (4), 682-699, 2019 | 68 | 2019 |
| Genomics and proteomics analysis of cultured primary rat hepatocytes J Beigel, K Fella, PJ Kramer, M Kroeger, P Hewitt Toxicology in Vitro 22 (1), 171-181, 2008 | 68 | 2008 |
