| RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth G Hatzivassiliou, K Song, I Yen, BJ Brandhuber, DJ Anderson, R Alvarado, ... Nature 464 (7287), 431-435, 2010 | 1835 | 2010 |
| Molecular determinants of the response of glioblastomas to EGFR kinase inhibitors IK Mellinghoff, MY Wang, I Vivanco, DA Haas-Kogan, S Zhu, EQ Dia, ... New England Journal of Medicine 353 (19), 2012-2024, 2005 | 1726 | 2005 |
| Dual role of phosphatidylinositol-3, 4, 5-trisphosphate in the activation of protein kinase B D Stokoe, LR Stephens, T Copeland, PRJ Gaffney, CB Reese, GF Painter, ... Science 277 (5325), 567-570, 1997 | 1643 | 1997 |
| Loss of tumor suppressor PTEN function increases B7-H1 expression and immunoresistance in glioma AT Parsa, JS Waldron, A Panner, CA Crane, IF Parney, JJ Barry, ... Nature medicine 13 (1), 84-88, 2007 | 1512 | 2007 |
| Protein kinase B kinases that mediate phosphatidylinositol 3, 4, 5-trisphosphate-dependent activation of protein kinase B L Stephens, K Anderson, D Stokoe, H Erdjument-Bromage, GF Painter, ... Science 279 (5351), 710-714, 1998 | 1429 | 1998 |
| A pharmacological map of the PI3-K family defines a role for p110α in insulin signaling ZA Knight, B Gonzalez, ME Feldman, ER Zunder, DD Goldenberg, ... Cell 125 (4), 733-747, 2006 | 1406 | 2006 |
| Activation of Raf as a result of recruitment to the plasma membrane D Stokoe, SG Macdonald, K Cadwallader, M Symons, JF Hancock Science 264 (5164), 1463-1467, 1994 | 1243 | 1994 |
| Loss of PTEN facilitates HIF-1-mediated gene expression W Zundel, C Schindler, D Haas-Kogan, A Koong, F Kaper, E Chen, ... Genes & development 14 (4), 391-396, 2000 | 1223 | 2000 |
| Diverse somatic mutation patterns and pathway alterations in human cancers Z Kan, BS Jaiswal, J Stinson, V Janakiraman, D Bhatt, HM Stern, P Yue, ... Nature 466 (7308), 869-873, 2010 | 1206 | 2010 |
| Induction of NF-κB by the Akt/PKB kinase LP Kane, VS Shapiro, D Stokoe, A Weiss Current Biology 9 (11), 601-604, 1999 | 1158 | 1999 |
| A dual PI3 kinase/mTOR inhibitor reveals emergent efficacy in glioma QW Fan, ZA Knight, DD Goldenberg, W Yu, KE Mostov, D Stokoe, ... Cancer cell 9 (5), 341-349, 2006 | 761 | 2006 |
| Akt activation by growth factors is a multiple-step process: the role of the PH domain A Bellacosa, TO Chan, NN Ahmed, K Datta, S Malstrom, D Stokoe, ... Oncogene 17 (3), 313-325, 1998 | 744 | 1998 |
| Identification of MAPKAP kinase 2 as a major enzyme responsible for the phosphorylation of the small mammalian heat shock proteins D Stokoe, K Engel, DG Campbell, P Cohen, M Gaestel FEBS letters 313 (3), 307-313, 1992 | 709 | 1992 |
| PDGF stimulates an increase in GTP–Rac via activation of phosphoinositide 3-kinase PT Hawkins, A Eguinoa, RG Qiu, D Stokoe, FT Cooke, R Walters, ... Current Biology 5 (4), 393-403, 1995 | 700 | 1995 |
| Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity T Maurer, LS Garrenton, A Oh, K Pitts, DJ Anderson, NJ Skelton, ... Proceedings of the National Academy of Sciences 109 (14), 5299-5304, 2012 | 698 | 2012 |
| A comprehensive transcriptional portrait of human cancer cell lines C Klijn, S Durinck, EW Stawiski, PM Haverty, Z Jiang, H Liu, J Degenhardt, ... Nature biotechnology 33 (3), 306-312, 2015 | 673 | 2015 |
| Protein kinase B (PKB/Akt) activity is elevated in glioblastoma cells due to mutation of the tumor suppressor PTEN/MMAC D Haas-Kogan, N Shalev, M Wong, G Mills, G Yount, D Stokoe Current Biology 8 (21), 1195-1198, 1998 | 613 | 1998 |
| MAPKAP kinase‐2; a novel protein kinase activated by mitogen‐activated protein kinase. D Stokoe, DG Campbell, S Nakielny, H Hidaka, SJ Leevers, C Marshall, ... The EMBO journal 11 (11), 3985-3994, 1992 | 595 | 1992 |
| High frequency of coexistent mutations of PIK3CA and PTEN genes in endometrial carcinoma K Oda, D Stokoe, Y Taketani, F McCormick Cancer research 65 (23), 10669-10673, 2005 | 576 | 2005 |
| Epidermal growth factor receptor, protein kinase B/Akt, and glioma response to erlotinib DA Haas-Kogan, MD Prados, T Tihan, DA Eberhard, N Jelluma, ... Journal of the National Cancer Institute 97 (12), 880-887, 2005 | 556 | 2005 |
