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James Finnigan
James Finnigan
Technical Director at Prozomix Limited
在 prozomix.com 的电子邮件经过验证
标题
引用次数
引用次数
年份
Screening and characterization of a diverse panel of metagenomic imine reductases for biocatalytic reductive amination
JR Marshall, P Yao, SL Montgomery, JD Finnigan, TW Thorpe, RB Palmer, ...
Nature chemistry 13 (2), 140-148, 2021
1352021
nanoDSF as screening tool for enzyme libraries and biotechnology development
AO Magnusson, A Szekrenyi, HJ Joosten, J Finnigan, S Charnock, ...
The FEBS journal 286 (1), 184-204, 2019
1192019
Cytochromes P450: History, Classes, Catalytic Mechanism, and Industrial Application
DJ Cook, JD Finnigan, K Cook, GW Black, SJ Charnock
Advances in Protein Chemistry and Structural Biology, 2016
862016
Serum amyloid A induces interleukin‐6 in dermal fibroblasts via Toll‐like receptor 2, interleukin‐1 receptor‐associated kinase 4 and nuclear factor‐κB
S O'Reilly, R Cant, M Ciechomska, J Finnigan, F Oakley, S Hambleton, ...
Immunology 143 (3), 331-340, 2014
782014
Multifunctional biocatalyst for conjugate reduction and reductive amination
TW Thorpe, JR Marshall, V Harawa, RE Ruscoe, A Cuetos, JD Finnigan, ...
Nature 604 (7904), 86-91, 2022
762022
Chemoenzymatic synthesis of substituted azepanes by sequential biocatalytic reduction and organolithium-mediated rearrangement
W Zawodny, SL Montgomery, JR Marshall, JD Finnigan, NJ Turner, ...
Journal of the American Chemical Society 140 (51), 17872-17877, 2018
662018
Role of toll-like receptors in systemic sclerosis
M Ciechomska, R Cant, J Finnigan, JM van Laar, S O'Reilly
Expert reviews in molecular medicine 15, e9, 2013
462013
Cytochromes P450 (P450s): A review of the class system with a focus on prokaryotic P450s
JD Finnigan, C Young, DJ Cook, SJ Charnock, GW Black
Advances in protein chemistry and structural biology 122, 289-320, 2020
452020
An engineered cytidine deaminase for biocatalytic production of a key intermediate of the Covid-19 antiviral molnupiravir
AJ Burke, WR Birmingham, Y Zhuo, TW Thorpe, B Zucoloto da Costa, ...
Journal of the American Chemical Society 144 (9), 3761-3765, 2022
332022
Synthesis of stereoenriched piperidines via chemo-enzymatic dearomatization of activated pyridines
V Harawa, TW Thorpe, JR Marshall, JJ Sangster, AK Gilio, L Pirvu, ...
Journal of the American Chemical Society 144 (46), 21088-21095, 2022
252022
Synthesis of pharmaceutically relevant 2‐aminotetralin and 3‐aminochroman derivatives via enzymatic reductive amination
J Citoler, V Harawa, JR Marshall, H Bevinakatti, JD Finnigan, ...
Angewandte Chemie 133 (46), 24661-24665, 2021
252021
Chemoenzymatic Cascades for the Enantioselective Synthesis of β‐Hydroxysulfides Bearing a Stereocentre at the C− O or C− S Bond by Ketoreductases
F Zhao, K Lauder, S Liu, JD Finnigan, SBR Charnock, SJ Charnock, ...
Angewandte Chemie International Edition 61 (31), e202202363, 2022
122022
An Efficient Synthesis of the Bicyclic Darunavir Side Chain Using Chemoenzymatic Catalysis
PS Riehl, J Lim, JD Finnigan, SJ Charnock, TK Hyster
Organic Process Research & Development 26 (7), 2096-2101, 2022
102022
Enantioselective Synthesis of α‐Thiocarboxylic Acids by Nitrilase Biocatalysed Dynamic Kinetic Resolution of α‐Thionitriles
K Lauder, S Anselmi, JD Finnigan, Y Qi, SJ Charnock, D Castagnolo
Chemistry–A European Journal 26 (46), 10422-10426, 2020
92020
A Coupled Ketoreductase‐Diaphorase Assay for the Detection of Polyethylene Terephthalate‐Hydrolyzing Activity
M Gimeno‐Pérez, JD Finnigan, C Echeverria, SJ Charnock, A Hidalgo, ...
ChemSusChem 15 (9), e202102750, 2022
72022
Advances in Protein Chemistry and Structural Biology
DJ Cook, JD Finnigan, K Cook, GW Black, SJ Charnock, CZ Christov
Cytochromes P450: history, classes, catalytic mechanism, and industrial …, 2016
72016
Biocatalysis in drug design: engineered reductive aminases (redams) are used to access chiral building blocks with multiple stereocenters
AR Casamajo, Y Yu, C Schnepel, C Morrill, R Barker, CW Levy, ...
Journal of the American Chemical Society 145 (40), 22041-22046, 2023
52023
A biocatalytic approach to a key intermediate for the synthesis of the COVID-19 experimental drug Molnupiravir
A Burke, W Birmingham, Y Zhuo, C BZd, R Crawshaw, T Thorpe, I Rowles, ...
52021
Regiodivergent Radical Termination for Intermolecular Biocatalytic C–C Bond Formation
MR Petchey, Y Ye, V Spelling, JD Finnigan, S Gittings, MJ Johansson, ...
Journal of the American Chemical Society 146 (7), 5005-5010, 2024
32024
A rapid, inexpensive and colorimetric high-throughput assay format for the screening commercial ketoreductase panels, providing indication of substrate scope, co-factor …
Y Qi, M Bawn, R Duncan, R Lloyd, J Finnigan, G Black, S Charnock
Practical Methods for Biocatalysis and Biotransformations 3, 266-276, 2016
32016
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