Screening and characterization of a diverse panel of metagenomic imine reductases for biocatalytic reductive amination JR Marshall, P Yao, SL Montgomery, JD Finnigan, TW Thorpe, RB Palmer, ... Nature chemistry 13 (2), 140-148, 2021 | 135 | 2021 |
nanoDSF as screening tool for enzyme libraries and biotechnology development AO Magnusson, A Szekrenyi, HJ Joosten, J Finnigan, S Charnock, ... The FEBS journal 286 (1), 184-204, 2019 | 119 | 2019 |
Cytochromes P450: History, Classes, Catalytic Mechanism, and Industrial Application DJ Cook, JD Finnigan, K Cook, GW Black, SJ Charnock Advances in Protein Chemistry and Structural Biology, 2016 | 86 | 2016 |
Serum amyloid A induces interleukin‐6 in dermal fibroblasts via Toll‐like receptor 2, interleukin‐1 receptor‐associated kinase 4 and nuclear factor‐κB S O'Reilly, R Cant, M Ciechomska, J Finnigan, F Oakley, S Hambleton, ... Immunology 143 (3), 331-340, 2014 | 78 | 2014 |
Multifunctional biocatalyst for conjugate reduction and reductive amination TW Thorpe, JR Marshall, V Harawa, RE Ruscoe, A Cuetos, JD Finnigan, ... Nature 604 (7904), 86-91, 2022 | 76 | 2022 |
Chemoenzymatic synthesis of substituted azepanes by sequential biocatalytic reduction and organolithium-mediated rearrangement W Zawodny, SL Montgomery, JR Marshall, JD Finnigan, NJ Turner, ... Journal of the American Chemical Society 140 (51), 17872-17877, 2018 | 66 | 2018 |
Role of toll-like receptors in systemic sclerosis M Ciechomska, R Cant, J Finnigan, JM van Laar, S O'Reilly Expert reviews in molecular medicine 15, e9, 2013 | 46 | 2013 |
Cytochromes P450 (P450s): A review of the class system with a focus on prokaryotic P450s JD Finnigan, C Young, DJ Cook, SJ Charnock, GW Black Advances in protein chemistry and structural biology 122, 289-320, 2020 | 45 | 2020 |
An engineered cytidine deaminase for biocatalytic production of a key intermediate of the Covid-19 antiviral molnupiravir AJ Burke, WR Birmingham, Y Zhuo, TW Thorpe, B Zucoloto da Costa, ... Journal of the American Chemical Society 144 (9), 3761-3765, 2022 | 33 | 2022 |
Synthesis of stereoenriched piperidines via chemo-enzymatic dearomatization of activated pyridines V Harawa, TW Thorpe, JR Marshall, JJ Sangster, AK Gilio, L Pirvu, ... Journal of the American Chemical Society 144 (46), 21088-21095, 2022 | 25 | 2022 |
Synthesis of pharmaceutically relevant 2‐aminotetralin and 3‐aminochroman derivatives via enzymatic reductive amination J Citoler, V Harawa, JR Marshall, H Bevinakatti, JD Finnigan, ... Angewandte Chemie 133 (46), 24661-24665, 2021 | 25 | 2021 |
Chemoenzymatic Cascades for the Enantioselective Synthesis of β‐Hydroxysulfides Bearing a Stereocentre at the C− O or C− S Bond by Ketoreductases F Zhao, K Lauder, S Liu, JD Finnigan, SBR Charnock, SJ Charnock, ... Angewandte Chemie International Edition 61 (31), e202202363, 2022 | 12 | 2022 |
An Efficient Synthesis of the Bicyclic Darunavir Side Chain Using Chemoenzymatic Catalysis PS Riehl, J Lim, JD Finnigan, SJ Charnock, TK Hyster Organic Process Research & Development 26 (7), 2096-2101, 2022 | 10 | 2022 |
Enantioselective Synthesis of α‐Thiocarboxylic Acids by Nitrilase Biocatalysed Dynamic Kinetic Resolution of α‐Thionitriles K Lauder, S Anselmi, JD Finnigan, Y Qi, SJ Charnock, D Castagnolo Chemistry–A European Journal 26 (46), 10422-10426, 2020 | 9 | 2020 |
A Coupled Ketoreductase‐Diaphorase Assay for the Detection of Polyethylene Terephthalate‐Hydrolyzing Activity M Gimeno‐Pérez, JD Finnigan, C Echeverria, SJ Charnock, A Hidalgo, ... ChemSusChem 15 (9), e202102750, 2022 | 7 | 2022 |
Advances in Protein Chemistry and Structural Biology DJ Cook, JD Finnigan, K Cook, GW Black, SJ Charnock, CZ Christov Cytochromes P450: history, classes, catalytic mechanism, and industrial …, 2016 | 7 | 2016 |
Biocatalysis in drug design: engineered reductive aminases (redams) are used to access chiral building blocks with multiple stereocenters AR Casamajo, Y Yu, C Schnepel, C Morrill, R Barker, CW Levy, ... Journal of the American Chemical Society 145 (40), 22041-22046, 2023 | 5 | 2023 |
A biocatalytic approach to a key intermediate for the synthesis of the COVID-19 experimental drug Molnupiravir A Burke, W Birmingham, Y Zhuo, C BZd, R Crawshaw, T Thorpe, I Rowles, ... | 5 | 2021 |
Regiodivergent Radical Termination for Intermolecular Biocatalytic C–C Bond Formation MR Petchey, Y Ye, V Spelling, JD Finnigan, S Gittings, MJ Johansson, ... Journal of the American Chemical Society 146 (7), 5005-5010, 2024 | 3 | 2024 |
A rapid, inexpensive and colorimetric high-throughput assay format for the screening commercial ketoreductase panels, providing indication of substrate scope, co-factor … Y Qi, M Bawn, R Duncan, R Lloyd, J Finnigan, G Black, S Charnock Practical Methods for Biocatalysis and Biotransformations 3, 266-276, 2016 | 3 | 2016 |