关注
Joel Leverson
Joel Leverson
VP Translational Biology, Treeline Biosciences
在 treeline.bio 的电子邮件经过验证
标题
引用次数
引用次数
年份
ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets
AJ Souers, JD Leverson, ER Boghaert, SL Ackler, ND Catron, J Chen, ...
Nature medicine 19 (2), 202-208, 2013
31182013
The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligase
CAP Joazeiro, SS Wing, H Huang, JD Leverson, T Hunter, YC Liu
Science 286 (5438), 309-312, 1999
13001999
Efficacy and biological correlates of response in a phase II study of venetoclax monotherapy in patients with acute myelogenous leukemia
M Konopleva, DA Pollyea, J Potluri, B Chyla, L Hogdal, T Busman, ...
Cancer discovery 6 (10), 1106-1117, 2016
10342016
From basic apoptosis discoveries to advanced selective BCL-2 family inhibitors
A Ashkenazi, WJ Fairbrother, JD Leverson, AJ Souers
Nature reviews drug discovery 16 (4), 273-284, 2017
8672017
Selective BCL-2 inhibition by ABT-199 causes on-target cell death in acute myeloid leukemia
R Pan, LJ Hogdal, JM Benito, D Bucci, L Han, G Borthakur, J Cortes, ...
Cancer discovery 4 (3), 362-375, 2014
7282014
Exploiting selective BCL-2 family inhibitors to dissect cell survival dependencies and define improved strategies for cancer therapy
JD Leverson, DC Phillips, MJ Mitten, ER Boghaert, D Diaz, SK Tahir, ...
Science translational medicine 7 (279), 279ra40-279ra40, 2015
5502015
Efficacy of venetoclax as targeted therapy for relapsed/refractory t (11; 14) multiple myeloma
S Kumar, JL Kaufman, C Gasparetto, J Mikhael, R Vij, B Pegourie, ...
Blood, The Journal of the American Society of Hematology 130 (22), 2401-2409, 2017
5282017
Functional analysis of human microtubule-based motor proteins, the kinesins and dyneins, in mitosis/cytokinesis using RNA interference
C Zhu, J Zhao, M Bibikova, JD Leverson, E Bossy-Wetzel, JB Fan, ...
Molecular biology of the cell 16 (7), 3187-3199, 2005
5172005
The Inhibitor of Apoptosis, cIAP2, Functions as a Ubiquitin-Protein Ligase and Promotes in VitroMonoubiquitination of Caspases 3 and 7
H Huang, CAP Joazeiro, E Bonfoco, S Kamada, JD Leverson, T Hunter
Journal of Biological Chemistry 275 (35), 26661-26664, 2000
5092000
Potent and selective small-molecule MCL-1 inhibitors demonstrate on-target cancer cell killing activity as single agents and in combination with ABT-263 (navitoclax)
JD Leverson, H Zhang, J Chen, SK Tahir, DC Phillips, J Xue, P Nimmer, ...
Cell death & disease 6 (1), e1590-e1590, 2015
4952015
Conserved function of RNF4 family proteins in eukaryotes: targeting a ubiquitin ligase to SUMOylated proteins
H Sun, JD Leverson, T Hunter
The EMBO journal 26 (18), 4102-4112, 2007
3652007
Pim-1 kinase and p100 cooperate to enhance c-Myb activity
JD Leverson, PJ Koskinen, FC Orrico, EM Rainio, KJ Jalkanen, AB Dash, ...
Molecular cell 2 (4), 417-425, 1998
3451998
Discovery of a Potent and Selective BCL-XL Inhibitor with in Vivo Activity
ZF Tao, L Hasvold, L Wang, X Wang, AM Petros, CH Park, ER Boghaert, ...
ACS medicinal chemistry letters 5 (10), 1088-1093, 2014
3152014
The Bcl-2 specific BH3 mimetic ABT-199: a promising targeted therapy for t (11; 14) multiple myeloma
C Touzeau, C Dousset, S Le Gouill, D Sampath, JD Leverson, AJ Souers, ...
Leukemia 28 (1), 210-212, 2014
3002014
Expression Profile of BCL-2, BCL-XL, and MCL-1 Predicts Pharmacological Response to the BCL-2 Selective Antagonist Venetoclax in Multiple Myeloma Models
EA Punnoose, JD Leverson, F Peale, ER Boghaert, LD Belmont, N Tan, ...
Molecular cancer therapeutics 15 (5), 1132-1144, 2016
2982016
Promising efficacy and acceptable safety of venetoclax plus bortezomib and dexamethasone in relapsed/refractory MM
P Moreau, A Chanan-Khan, AW Roberts, AB Agarwal, T Facon, S Kumar, ...
Blood, The Journal of the American Society of Hematology 130 (22), 2392-2400, 2017
2912017
Potent and selective inhibitors of Akt kinases slow the progress of tumors in vivo
Y Luo, AR Shoemaker, X Liu, KW Woods, SA Thomas, R de Jong, EK Han, ...
Molecular cancer therapeutics 4 (6), 977-986, 2005
2752005
Synthetic lethality of combined Bcl-2 inhibition and p53 activation in AML: mechanisms and superior antileukemic efficacy
R Pan, V Ruvolo, H Mu, JD Leverson, G Nichols, JC Reed, M Konopleva, ...
Cancer cell 32 (6), 748-760. e6, 2017
2542017
The APC11 RING-H2 finger mediates E2-dependent ubiquitination
JD Leverson, CAP Joazeiro, AM Page, H Huang, P Hieter, T Hunter
Molecular biology of the cell 11 (7), 2315-2325, 2000
2292000
Potential mechanisms of resistance to venetoclax and strategies to circumvent it
SK Tahir, ML Smith, P Hessler, LR Rapp, KB Idler, CH Park, JD Leverson, ...
BMC cancer 17, 1-10, 2017
2122017
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