| Structure of the human M2 muscarinic acetylcholine receptor bound to an antagonist K Haga, AC Kruse, H Asada, T Yurugi-Kobayashi, M Shiroishi, C Zhang, ... Nature 482 (7386), 547-551, 2012 | 932 | 2012 |
| Structure and function of an irreversible agonist-β2 adrenoceptor complex DM Rosenbaum, C Zhang, JA Lyons, R Holl, D Aragao, DH Arlow, ... Nature 469 (7329), 236-240, 2011 | 905 | 2011 |
| High-resolution crystal structure of human protease-activated receptor 1 C Zhang, Y Srinivasan, DH Arlow, JJ Fung, D Palmer, Y Zheng, HF Green, ... Nature 492 (7429), 387-392, 2012 | 539 | 2012 |
| Versatile and multivalent nanobodies efficiently neutralize SARS-CoV-2 Y Xiang, S Nambulli, Z Xiao, H Liu, Z Sang, WP Duprex, ... Science 370 (6523), 1479-1484, 2020 | 370 | 2020 |
| Cryo-EM structure of the human cannabinoid receptor CB2-Gi signaling complex C Xing, Y Zhuang, TH Xu, Z Feng, XE Zhou, M Chen, L Wang, X Meng, ... Cell 180 (4), 645-654. e13, 2020 | 222 | 2020 |
| Structural insights into the human D1 and D2 dopamine receptor signaling complexes Y Zhuang, P Xu, C Mao, L Wang, B Krumm, XE Zhou, S Huang, H Liu, ... Cell 184 (4), 931-942. e18, 2021 | 182 | 2021 |
| Structural insights into binding specificity, efficacy and bias of a β2AR partial agonist M Masureel, Y Zou, LP Picard, E van der Westhuizen, JP Mahoney, ... Nature chemical biology 14 (11), 1059-1066, 2018 | 178 | 2018 |
| Cholesterol increases kinetic, energetic, and mechanical stability of the human β2-adrenergic receptor M Zocher, C Zhang, SGF Rasmussen, BK Kobilka, DJ Müller Proceedings of the National Academy of Sciences 109 (50), E3463-E3472, 2012 | 178 | 2012 |
| Cryo-EM structure of oxysterol-bound human Smoothened coupled to a heterotrimeric Gi X Qi, H Liu, B Thompson, J McDonald, C Zhang, X Li Nature 571 (7764), 279-283, 2019 | 149 | 2019 |
| Imaging G protein–coupled receptors while quantifying their ligand-binding free-energy landscape D Alsteens, M Pfreundschuh, C Zhang, PM Spoerri, SR Coughlin, ... Nature methods 12 (9), 845-851, 2015 | 126 | 2015 |
| Covalent agonists for studying G protein-coupled receptor activation D Weichert, AC Kruse, A Manglik, C Hiller, C Zhang, H Hübner, ... Proceedings of the National Academy of Sciences 111 (29), 10744-10748, 2014 | 117 | 2014 |
| Orthosteric and allosteric action of the C5a receptor antagonists H Liu, HR Kim, RNVK Deepak, L Wang, KY Chung, H Fan, Z Wei, ... Nature structural & molecular biology 25 (6), 472-481, 2018 | 114 | 2018 |
| Potent neutralizing nanobodies resist convergent circulating variants of SARS-CoV-2 by targeting diverse and conserved epitopes D Sun, Z Sang, YJ Kim, Y Xiang, T Cohen, AK Belford, A Huet, JF Conway, ... Nature communications 12 (1), 4676, 2021 | 100 | 2021 |
| Structure of formylpeptide receptor 2-Gi complex reveals insights into ligand recognition and signaling Y Zhuang, H Liu, X Edward Zhou, R Kumar Verma, PW de Waal, W Jang, ... Nature communications 11 (1), 885, 2020 | 96 | 2020 |
| Trypsin inhibitory loop is an excellent lead structure to design serine protease inhibitors and antimicrobial peptides J Li, C Zhang, X Xu, J Wang, H Yu, R Lai, W Gong The FASEB Journal 21 (10), 2466-2473, 2007 | 89 | 2007 |
| G protein–coupled receptors in asthma therapy: pharmacology and drug action SG Wendell, H Fan, C Zhang Pharmacological reviews 72 (1), 1-49, 2020 | 88 | 2020 |
| Identifying and quantifying two ligand-binding sites while imaging native human membrane receptors by AFM M Pfreundschuh, D Alsteens, R Wieneke, C Zhang, SR Coughlin, ... Nature communications 6 (1), 8857, 2015 | 81 | 2015 |
| Structure of human steroid 5α-reductase 2 with the anti-androgen drug finasteride Q Xiao, L Wang, S Supekar, T Shen, H Liu, F Ye, J Huang, H Fan, Z Wei, ... Nature communications 11 (1), 5430, 2020 | 76 | 2020 |
| Structures of the human PGD2 receptor CRTH2 reveal novel mechanisms for ligand recognition L Wang, D Yao, RNVK Deepak, H Liu, Q Xiao, H Fan, W Gong, Z Wei, ... Molecular cell 72 (1), 48-59. e4, 2018 | 66 | 2018 |
| Mechanism of dopamine binding and allosteric modulation of the human D1 dopamine receptor Y Zhuang, B Krumm, H Zhang, XE Zhou, Y Wang, XP Huang, Y Liu, ... Cell research 31 (5), 593-596, 2021 | 60 | 2021 |
