Delta-secretase phosphorylation by SRPK2 enhances its enzymatic activity, provoking pathogenesis in Alzheimer’s disease ZH Wang, P Liu, X Liu, FP Manfredsson, IM Sandoval, SP Yu, JZ Wang, ... Molecular cell 67 (5), 812-825. e5, 2017 | 56 | 2017 |
High-fat diet-induced diabetes couples to Alzheimer’s disease through inflammation-activated C/EBPβ/AEP pathway P Liu, ZH Wang, SS Kang, X Liu, Y Xia, CB Chan, K Ye Molecular psychiatry 27 (8), 3396-3409, 2022 | 35 | 2022 |
Delta-secretase (AEP) mediates tau-splicing imbalance and accelerates cognitive decline in tauopathies ZH Wang, P Liu, X Liu, SP Yu, JZ Wang, K Ye Journal of Experimental Medicine 215 (12), 3038-3056, 2018 | 34 | 2018 |
ApoE4 activates C/EBPβ/δ-secretase with 27-hydroxycholesterol, driving the pathogenesis of Alzheimer’s disease ZH Wang, Y Xia, P Liu, X Liu, L Edgington-Mitchell, K Lei, SP Yu, ... Progress in neurobiology 202, 102032, 2021 | 32 | 2021 |
TrkB receptor cleavage by delta-secretase abolishes its phosphorylation of APP, aggravating Alzheimer’s disease pathologies Y Xia, ZH Wang, P Liu, L Edgington-Mitchell, X Liu, XC Wang, K Ye Molecular Psychiatry 26 (7), 2943-2963, 2021 | 26 | 2021 |
Neuronal ApoE4 stimulates C/EBPβ activation, promoting Alzheimer’s disease pathology in a mouse model ZH Wang, Y Xia, Z Wu, SS Kang, J Zhang, P Liu, X Liu, W Song, V Huin, ... Progress in Neurobiology 209, 102212, 2022 | 22 | 2022 |
Neuronal C/EBPβ/AEP pathway shortens life span via selective GABAnergic neuronal degeneration by FOXO repression Y Xia, H Qadota, ZH Wang, P Liu, X Liu, KX Ye, CJ Matheny, K Berglund, ... Science advances 8 (13), eabj8658, 2022 | 20 | 2022 |
A TrkB cleavage fragment in hippocampus promotes Depressive-Like behavior in mice J Wang, H Yu, X Li, F Li, H Chen, X Zhang, Y Wang, R Xu, F Gao, J Wang, ... Brain, Behavior, and Immunity 119, 56-83, 2024 | | 2024 |