ROSETTA3: an object-oriented software suite for the simulation and design of macromolecules A Leaver-Fay, M Tyka, SM Lewis, OF Lange, J Thompson, R Jacak, ... Methods in enzymology 487, 545-574, 2011 | 1967 | 2011 |
Computational design of self-assembling protein nanomaterials with atomic level accuracy NP King, W Sheffler, MR Sawaya, BS Vollmar, JP Sumida, I André, ... Science 336 (6085), 1171-1174, 2012 | 740 | 2012 |
Accurate design of co-assembling multi-component protein nanomaterials NP King, JB Bale, W Sheffler, DE McNamara, S Gonen, T Gonen, ... Nature 510 (7503), 103-108, 2014 | 610 | 2014 |
Structure prediction for CASP8 with all‐atom refinement using Rosetta S Raman, R Vernon, J Thompson, M Tyka, R Sadreyev, J Pei, D Kim, ... Proteins: Structure, Function, and Bioinformatics 77 (S9), 89-99, 2009 | 594 | 2009 |
Accurate design of megadalton-scale two-component icosahedral protein complexes JB Bale, S Gonen, Y Liu, W Sheffler, D Ellis, C Thomas, D Cascio, ... Science 353 (6297), 389-394, 2016 | 556 | 2016 |
A new generation of crystallographic validation tools for the protein data bank RJ Read, PD Adams, WB Arendall, AT Brunger, P Emsley, RP Joosten, ... Structure 19 (10), 1395-1412, 2011 | 502 | 2011 |
Design of a hyperstable 60-subunit protein icosahedron Y Hsia, JB Bale, S Gonen, D Shi, W Sheffler, KK Fong, U Nattermann, ... Nature 535 (7610), 136-139, 2016 | 454 | 2016 |
De novo design of protein structure and function with RFdiffusion JL Watson, D Juergens, NR Bennett, BL Trippe, J Yim, HE Eisenach, ... Nature 620 (7976), 1089-1100, 2023 | 443 | 2023 |
Induction of potent neutralizing antibody responses by a designed protein nanoparticle vaccine for respiratory syncytial virus J Marcandalli, B Fiala, S Ols, M Perotti, W de van der Schueren, J Snijder, ... Cell 176 (6), 1420-1431. e17, 2019 | 394 | 2019 |
De novo design of a fluorescence-activating β-barrel J Dou, AA Vorobieva, W Sheffler, LA Doyle, H Park, MJ Bick, B Mao, ... Nature 561 (7724), 485-491, 2018 | 334 | 2018 |
Structure prediction for CASP7 targets using extensive all‐atom refinement with Rosetta@ home R Das, B Qian, S Raman, R Vernon, J Thompson, P Bradley, S Khare, ... Proteins: Structure, Function, and Bioinformatics 69 (S8), 118-128, 2007 | 276 | 2007 |
Design of protein-binding proteins from the target structure alone L Cao, B Coventry, I Goreshnik, B Huang, W Sheffler, JS Park, KM Jude, ... Nature 605 (7910), 551-560, 2022 | 251 | 2022 |
Broadly applicable and accurate protein design by integrating structure prediction networks and diffusion generative models JL Watson, D Juergens, NR Bennett, BL Trippe, J Yim, HE Eisenach, ... BioRxiv, 2022.12. 09.519842, 2022 | 176 | 2022 |
Accurate computational design of multipass transmembrane proteins P Lu, D Min, F DiMaio, KY Wei, MD Vahey, SE Boyken, Z Chen, JA Fallas, ... Science 359 (6379), 1042-1046, 2018 | 176 | 2018 |
Enhancing and shaping the immunogenicity of native-like HIV-1 envelope trimers with a two-component protein nanoparticle PJM Brouwer, A Antanasijevic, Z Berndsen, A Yasmeen, B Fiala, TPL Bijl, ... Nature Communications 10 (1), 4272, 2019 | 160 | 2019 |
RosettaHoles: rapid assessment of protein core packing for structure prediction, refinement, design, and validation W Sheffler, D Baker Protein Science 18 (1), 229-239, 2009 | 160 | 2009 |
Computational design of self-assembling cyclic protein homo-oligomers JA Fallas, G Ueda, W Sheffler, V Nguyen, DE McNamara, B Sankaran, ... Nature chemistry 9 (4), 353-360, 2017 | 158 | 2017 |
De novo design of self-assembling helical protein filaments H Shen, JA Fallas, E Lynch, W Sheffler, B Parry, N Jannetty, J Decarreau, ... Science 362 (6415), 705-709, 2018 | 138 | 2018 |
Efficient flexible backbone protein–protein docking for challenging targets NA Marze, SS Roy Burman, W Sheffler, JJ Gray Bioinformatics 34 (20), 3461-3469, 2018 | 136 | 2018 |
Tailored design of protein nanoparticle scaffolds for multivalent presentation of viral glycoprotein antigens G Ueda, A Antanasijevic, JA Fallas, W Sheffler, J Copps, D Ellis, ... Elife 9, e57659, 2020 | 135 | 2020 |