Differential modulation of tissue function and therapeutic potential of selective inhibitors of cyclic nucleotide phosphodiesterase isoenzymes CD Nicholson, RAJ Challiss, M Shahid Trends in Pharmacological Sciences 12, 19-27, 1991 | 627 | 1991 |
Structural, signalling and regulatory properties of the group I metabotropic glutamate receptors: prototypic family C G-protein-coupled receptors E Hermans, RAJ Challiss Biochemical Journal 359, 465-484, 2001 | 507 | 2001 |
Neuronal Ca2+ stores: activation and function PB Simpson, RAJ Challiss, SR Nahorski Trends in Neurosciences 18 (7), 299-306, 1995 | 377 | 1995 |
Muscarinic acetylcholine receptor subtypes in smooth muscle RM Eglen, H Reddy, N Watson, RAJ Challiss Trends in Pharmacological Sciences 15 (4), 114-119, 1994 | 325 | 1994 |
Lithium and the phosphoinositide cycle: an example of uncompetitive inhibition and its pharmacological consequences SR Nahorski, CI Ragan, RAJ Challiss Trends in Pharmacological Sciences 12, 297-303, 1991 | 281 | 1991 |
Mass measurements of inositol 1,4,5-trisphosphate in rat cerebral cortex slices using a radioreceptor assay: effects of neurotransmitters and depolarization RAJ Challiss, IH Batty, SR Nahorski Biochemical and Biophysical Research Communications 157 (2), 684-691, 1988 | 232 | 1988 |
Differential regulation of muscarinic acetylcholine receptor-sensitive polyphosphoinositide pools and consequences for signaling in human neuroblastoma cells GB Willars, SR Nahorski, RAJ Challiss Journal of Biological Chemistry 273 (9), 5037-5046, 1998 | 190 | 1998 |
Nitric oxide is a volume transmitter regulating postsynaptic excitability at a glutamatergic synapse JR Steinert, C Kopp-Scheinpflug, C Baker, RAJ Challiss, R Mistry, ... Neuron 60 (4), 642-656, 2008 | 185 | 2008 |
Receptor-specific messenger oscillations MS Nash, KW Young, RA John Challiss, SR Nahorski Nature 413 (6854), 381-382, 2001 | 167 | 2001 |
Heterogeneity of [3H]inositol 1,4,5-trisphosphate binding sites in adrenal-cortical membranes: characterization and validation of a radioreceptor assay RAJ Challiss, ER Chilvers, AL Willcocks, SR Nahorski Biochemical Journal 265, 421-427, 1990 | 167 | 1990 |
Non-visual GRKs: are we seeing the whole picture? JM Willets, RAJ Challiss, SR Nahorski Trends in Pharmacological Sciences 24 (12), 626-633, 2003 | 160 | 2003 |
Biochemical adaptation in the skeletal muscle of rats depleted of creatine with the substrate analogue β-guanidinopropionic acid EA Shoubridge, RAJ Challiss, DJ Hayes, GK Radda Biochemical Journal 232, 125-131, 1985 | 160 | 1985 |
The effects of insulin on transport and metabolism of glucose in skeletal muscle from hyperthyroid and hypothyroid rats GD Dimitriadis, M Parry-Billings, S Bevan, B Leighton, U Krause, T Piva, ... European Journal of Clinical Investigation 27 (6), 475-483, 1997 | 141 | 1997 |
Increased nicotinamide adenine dinucleotide phosphate oxidase 4 expression mediates intrinsic airway smooth muscle hypercontractility in asthma A Sutcliffe, F Hollins, E Gomez, R Saunders, C Doe, MD Cooke, ... American Journal of Respiratory and Critical Care Medicine 185 (3), 267-274, 2012 | 137 | 2012 |
Phosphorus-31 NMR magnetization-transfer measurements of ATP turnover during steady-state isometric muscle contraction in the rat hind limb in vivo KM Brindle, MJ Blackledge, RAJ Challiss, GK Radda Biochemistry 28 (11), 4887-4893, 1989 | 128 | 1989 |
New developments in the molecular pharmacology of the myo-inositol 1,4,5-trisphosphate receptor RA Wilcox, WU Primrose, SR Nahorski, RAJ Challiss Trends in Pharmacological Sciences 19 (11), 467-475, 1998 | 124 | 1998 |
Group‐I metabotropic glutamate receptors, mGlu1a and mGlu5a, couple to extracellular signal‐regulated kinase (ERK) activation via distinct, but overlapping, signalling pathways S Thandi, JL Blank, RAJ Challiss Journal of Neurochemistry 83 (5), 1139-1153, 2002 | 123 | 2002 |
Determinants of metabotropic glutamate receptor-5 (mGlu5)-mediated Ca2+ and inositol 1,4,5-trisphosphate oscillation frequency MS Nash, MJ Schell, PJ Atkinson, NR Johnston, SR Nahorski, ... Journal of Biological Chemistry 277 (39), 35947-35960, 2002 | 123 | 2002 |
Gq/11 and Gi/o activation profiles in CHO cells expressing human muscarinic acetylcholine receptors: dependence on agonist as well as receptor‐subtype EC Akam, RAJ Challiss, SR Nahorski British Journal of Pharmacology 132 (4), 950-958, 2001 | 122 | 2001 |
The effect of prostaglandins E1, E2 and F2α and indomethacin on the sensitivity of glycolysis and glycogen synthesis to insulin in stripped soleus muscles of the rat B Leighton, L Budohoski, FJ Lozeman, RAJ Challiss, EA Newsholme Biochemical Journal 227 (1), 337, 1985 | 116 | 1985 |