| LRRK2 phosphorylates moesin at threonine-558: characterization of how Parkinson's disease mutants affect kinase activity M Jaleel, RJ Nichols, M Deak, DG Campbell, F Gillardon, A Knebel, ... Biochemical Journal 405 (2), 307-317, 2007 | 623 | 2007 |
| 14-3-3 binding to LRRK2 is disrupted by multiple Parkinson's disease-associated mutations and regulates cytoplasmic localization RJ Nichols, N Dzamko, NA Morrice, DG Campbell, M Deak, A Ordureau, ... Biochemical Journal 430 (3), 393-404, 2010 | 423 | 2010 |
| Inhibition of LRRK2 kinase activity leads to dephosphorylation of Ser910/Ser935, disruption of 14-3-3 binding and altered cytoplasmic localization N Dzamko, M Deak, F Hentati, AD Reith, AR Prescott, DR Alessi, ... Biochemical Journal 430 (3), 405-413, 2010 | 412 | 2010 |
| The vaccinia-related kinases phosphorylate the N′ terminus of BAF, regulating its interaction with DNA and its retention in the nucleus RJ Nichols, MS Wiebe, P Traktman Molecular biology of the cell 17 (5), 2451-2464, 2006 | 266 | 2006 |
| Substrate specificity and inhibitors of LRRK2, a protein kinase mutated in Parkinson's disease RJ Nichols, N Dzamko, JE Hutti, LC Cantley, M Deak, J Moran, ... Biochemical Journal 424 (1), 47-60, 2009 | 233 | 2009 |
| Characterization of three paralogous members of the Mammalian vaccinia related kinase family RJ Nichols, P Traktman Journal of Biological Chemistry 279 (9), 7934-7946, 2004 | 154 | 2004 |
| Parkinson disease-associated mutation R1441H in LRRK2 prolongs the “active state” of its GTPase domain J Liao, CX Wu, C Burlak, S Zhang, H Sahm, M Wang, ZY Zhang, ... Proceedings of the National Academy of Sciences 111 (11), 4055-4060, 2014 | 137 | 2014 |
| Identification of protein phosphatase 1 as a regulator of the LRRK2 phosphorylation cycle E Lobbestael, J Zhao, IN Rudenko, A Beylina, F Gao, J Wetter, M Beullens, ... Biochemical Journal 456 (1), 119-128, 2013 | 108 | 2013 |
| Phosphorylation of LRRK2 serines 955 and 973 is disrupted by Parkinson’s disease mutations and LRRK2 pharmacological inhibition EA Doggett, J Zhao, CN Mork, D Hu, RJ Nichols Journal of neurochemistry 120 (1), 37-45, 2012 | 104 | 2012 |
| LRRK2‐mediated Rab10 phosphorylation in immune cells from Parkinson's disease patients F Atashrazm, D Hammond, G Perera, MF Bolliger, E Matar, GM Halliday, ... Movement disorders 34 (3), 406-415, 2019 | 94 | 2019 |
| LRRK2 kinase activity and biology are not uniformly predicted by its autophosphorylation and cellular phosphorylation site status A Reynolds, EA Doggett, SM Riddle, CS Lebakken, RJ Nichols Frontiers in molecular neuroscience 7, 54, 2014 | 78 | 2014 |
| LRRK2 dephosphorylation increases its ubiquitination J Zhao, TP Molitor, JW Langston, RJ Nichols Biochemical Journal 469 (1), 107-120, 2015 | 73 | 2015 |
| Mice deficient in the serine/threonine protein kinase VRK1 are infertile due to a progressive loss of spermatogonia MS Wiebe, RJ Nichols, TP Molitor, JK Lindgren, P Traktman Biology of reproduction 82 (1), 182-193, 2010 | 63 | 2010 |
| P62/SQSTM1 is a novel leucine-rich repeat kinase 2 (LRRK2) substrate that enhances neuronal toxicity AF Kalogeropulou, J Zhao, MF Bolliger, A Memou, S Narasimha, ... Biochemical journal 475 (7), 1271-1293, 2018 | 60 | 2018 |
| Multisystem Lewy body disease and the other parkinsonian disorders JW Langston, B Schüle, L Rees, RJ Nichols, C Barlow Nature genetics 47 (12), 1378-1384, 2015 | 58 | 2015 |
| The vaccinia virus gene I2L encodes a membrane protein with an essential role in virion entry RJ Nichols, E Stanitsa, B Unger, P Traktman Journal of virology 82 (20), 10247-10261, 2008 | 56 | 2008 |
| Reduced LRRK2 in association with retromer dysfunction in post-mortem brain tissue from LRRK2 mutation carriers Y Zhao, G Perera, J Takahashi-Fujigasaki, DC Mash, JPG Vonsattel, ... Brain 141 (2), 486-495, 2018 | 53 | 2018 |
| LRRK2 levels and phosphorylation in Parkinson's disease brain and cases with restricted Lewy bodies N Dzamko, AM Gysbers, R Bandopadhyay, MF Bolliger, A Uchino, Y Zhao, ... Movement Disorders 32 (3), 423-432, 2017 | 50 | 2017 |
| Screening for novel LRRK2 inhibitors using a high-throughput TR-FRET cellular assay for LRRK2 Ser935 phosphorylation SB Hermanson, CB Carlson, SM Riddle, J Zhao, KW Vogel, RJ Nichols, ... Public Library of Science 7 (8), e43580, 2012 | 44 | 2012 |
| Parkinson's disease-associated mutations in the GTPase domain of LRRK2 impair its nucleotide-dependent conformational dynamics CX Wu, J Liao, Y Park, X Reed, VA Engel, NC Hoang, Y Takagi, ... Journal of Biological Chemistry 294 (15), 5907-5913, 2019 | 28 | 2019 |
Nicolas DzamkoUniversity of Sydney在 sydney.edu.au 的电子邮件经过验证
