Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes JC Barrett, DG Clayton, P Concannon, B Akolkar, JD Cooper, HA Erlich, ... Nature genetics 41 (6), 703-707, 2009 | 2157 | 2009 |
Defective suppressor function in CD4+ CD25+ T-cells from patients with type 1 diabetes S Lindley, CM Dayan, A Bishop, BO Roep, M Peakman, TIM Tree Diabetes 54 (1), 92-99, 2005 | 1153 | 2005 |
HLA DR-DQ haplotypes and genotypes and type 1 diabetes risk: analysis of the type 1 diabetes genetics consortium families H Erlich, AM Valdes, J Noble, JA Carlson, M Varney, P Concannon, ... Diabetes 57 (4), 1084-1092, 2008 | 916 | 2008 |
Demonstration of islet-autoreactive CD8 T cells in insulitic lesions from recent onset and long-term type 1 diabetes patients KT Coppieters, F Dotta, N Amirian, PD Campbell, TWH Kay, MA Atkinson, ... Journal of Experimental Medicine 209 (1), 51-60, 2012 | 741 | 2012 |
Coxsackie B4 virus infection of β cells and natural killer cell insulitis in recent-onset type 1 diabetic patients F Dotta, S Censini, AGS van Halteren, L Marselli, M Masini, S Dionisi, ... Proceedings of the National Academy of Sciences 104 (12), 5115-5120, 2007 | 722 | 2007 |
Fine mapping of type 1 diabetes susceptibility loci and evidence for colocalization of causal variants with lymphoid gene enhancers S Onengut-Gumuscu, WM Chen, O Burren, NJ Cooper, AR Quinlan, ... Nature genetics 47 (4), 381-386, 2015 | 684 | 2015 |
Autoreactive T cell responses show proinflammatory polarization in diabetes but a regulatory phenotype in health S Arif, TI Tree, TP Astill, JM Tremble, AJ Bishop, CM Dayan, BO Roep, ... The Journal of clinical investigation 113 (3), 451-463, 2004 | 590 | 2004 |
Induction of Treg by monocyte‐derived DC modulated by vitamin D3 or dexamethasone: Differential role for PD‐L1 WWJ Unger, S Laban, FS Kleijwegt, AR van der Slik, BO Roep European journal of immunology 39 (11), 3147-3159, 2009 | 512 | 2009 |
The role of T-cells in the pathogenesis of Type 1 diabetes: from cause to cure BO Roep Diabetologia 46, 305-321, 2003 | 511 | 2003 |
CTLs are targeted to kill β cells in patients with type 1 diabetes through recognition of a glucose-regulated preproinsulin epitope A Skowera, RJ Ellis, R Varela-Calviño, S Arif, GC Huang, C Van-Krinks, ... The Journal of clinical investigation 118 (10), 3390-3402, 2008 | 460 | 2008 |
Type 1 diabetes mellitus as a disease of the β-cell (do not blame the immune system?) BO Roep, S Thomaidou, R van Tienhoven, A Zaldumbide Nature Reviews Endocrinology 17 (3), 150-161, 2021 | 401 | 2021 |
A genome-wide meta-analysis of six type 1 diabetes cohorts identifies multiple associated loci JP Bradfield, HQ Qu, K Wang, H Zhang, PM Sleiman, CE Kim, FD Mentch, ... PLoS genetics 7 (9), e1002293, 2011 | 390 | 2011 |
Interleukin-1 antagonism in type 1 diabetes of recent onset: two multicentre, randomised, double-blind, placebo-controlled trials A Moran, B Bundy, DJ Becker, LA DiMeglio, SE Gitelman, R Goland, ... The Lancet 381 (9881), 1905-1915, 2013 | 365 | 2013 |
Autoreactive CD8 T cells associated with β cell destruction in type 1 diabetes GGM Pinkse, OHM Tysma, CAM Bergen, MGD Kester, F Ossendorp, ... Proceedings of the National Academy of Sciences 102 (51), 18425-18430, 2005 | 361 | 2005 |
Development of type 1 diabetes despite severe hereditary B-cell deficiency S Martin, D Wolf-Eichbaum, G Duinkerken, WA Scherbaum, H Kolb, ... New England Journal of Medicine 345 (14), 1036-1040, 2001 | 355 | 2001 |
Translational mini-review series on type 1 diabetes: systematic analysis of T cell epitopes in autoimmune diabetes TP Di Lorenzo, M Peakman, BO Roep Clinical & Experimental Immunology 148 (1), 1-16, 2007 | 311 | 2007 |
The vitamin D receptor gene FokI polymorphism: Functional impact on the immune system E van Etten, L Verlinden, A Giulietti, E Ramos‐Lopez, DD Branisteanu, ... European journal of immunology 37 (2), 395-405, 2007 | 305 | 2007 |
Antigen targets of type 1 diabetes autoimmunity BO Roep, M Peakman Cold Spring Harbor perspectives in medicine 2 (4), a007781, 2012 | 304 | 2012 |
HLA class I and genetic susceptibility to type 1 diabetes: results from the Type 1 Diabetes Genetics Consortium JA Noble, AM Valdes, MD Varney, JA Carlson, P Moonsamy, AL Fear, ... Diabetes 59 (11), 2972-2979, 2010 | 301 | 2010 |
KIR in type 1 diabetes: disparate distribution of activating and inhibitory natural killer cell receptors in patients versus HLA-matched control subjects AR van der Slik, BPC Koeleman, W Verduijn, GJ Bruining, BO Roep, ... Diabetes 52 (10), 2639-2642, 2003 | 289 | 2003 |