| A unified model for predicting human hepatic, metabolic clearance from in vitro intrinsic clearance data in hepatocytes and microsomes RJ Riley, DF McGinnity, RP Austin Drug Metabolism and Disposition 33 (9), 1304-1311, 2005 | 417 | 2005 |
| Epoxidation of olefins by cytochrome P450: evidence from site-specific mutagenesis for hydroperoxo-iron as an electrophilic oxidant ADN Vaz, DF McGinnity, MJ Coon Proceedings of the National Academy of Sciences 95 (7), 3555-3560, 1998 | 412 | 1998 |
| Evaluation of fresh and cryopreserved hepatocytes as in vitro drug metabolism tools for the prediction of metabolic clearance DF McGinnity, MG Soars, RA Urbanowicz, RJ Riley Drug metabolism and disposition 32 (11), 1247-1253, 2004 | 372 | 2004 |
| From ATP to AZD6140: the discovery of an orally active reversible P2Y12 receptor antagonist for the prevention of thrombosis B Springthorpe, A Bailey, P Barton, TN Birkinshaw, RV Bonnert, ... Bioorganic & medicinal chemistry letters 17 (21), 6013-6018, 2007 | 301 | 2007 |
| The pivotal role of hepatocytes in drug discovery MG Soars, DF McGinnity, K Grime, RJ Riley Chemico-biological interactions 168 (1), 2-15, 2007 | 203 | 2007 |
| Optimising proteolysis-targeting chimeras (PROTACs) for oral drug delivery: a drug metabolism and pharmacokinetics perspective A Pike, B Williamson, S Harlfinger, S Martin, DF McGinnity Drug Discovery Today 25 (10), 1793-1800, 2020 | 164 | 2020 |
| Automated definition of the enzymology of drug oxidation by the major human drug metabolizing cytochrome P450s DF McGinnity, AJ Parker, M Soars, RJ Riley Drug Metabolism and Disposition 28 (11), 1327-1334, 2000 | 151 | 2000 |
| Evaluation of human pharmacokinetics, therapeutic dose and exposure predictions using marketed oral drugs DF McGinnity, J Collington, RP Austin, RJ Riley Current drug metabolism 8 (5), 463-479, 2007 | 134 | 2007 |
| Evaluation of time-dependent cytochrome P450 inhibition using cultured human hepatocytes DF McGinnity, AJ Berry, JR Kenny, K Grime, RJ Riley Drug metabolism and disposition 34 (8), 1291-1300, 2006 | 128 | 2006 |
| Evaluation of multiple in vitro systems for assessment of CYP3A4 induction in drug discovery: human hepatocytes, pregnane X receptor reporter gene, and Fa2N-4 and HepaRG cells DF McGinnity, G Zhang, JR Kenny, GA Hamilton, S Otmani, KR Stams, ... Drug metabolism and disposition 37 (6), 1259-1268, 2009 | 123 | 2009 |
| Prediction of human renal clearance from preclinical species for a diverse set of drugs that exhibit both active secretion and net reabsorption SW Paine, K Ménochet, R Denton, DF McGinnity, RJ Riley Drug metabolism and disposition 39 (6), 1008-1013, 2011 | 111 | 2011 |
| Multiple activated oxygen species in P450 catalysis: contributions to specificity in drug metabolism MJ Coon, ADN Vaz, DF McGinnity, HM Peng Drug metabolism and disposition 26 (12), 1190-1193, 1998 | 100 | 1998 |
| Improving the accuracy of predicted human pharmacokinetics: lessons learned from the AstraZeneca drug pipeline over two decades M Davies, RDO Jones, K Grime, R Jansson-Löfmark, AJ Fretland, ... Trends in pharmacological sciences 41 (6), 390-408, 2020 | 93 | 2020 |
| Application of in silico, in vitro and preclinical pharmacokinetic data for the effective and efficient prediction of human pharmacokinetics KH Grime, P Barton, DF McGinnity Molecular pharmaceutics 10 (4), 1191-1206, 2013 | 85 | 2013 |
| Discovery of AZD9833, a potent and orally bioavailable selective estrogen receptor degrader and antagonist JS Scott, TA Moss, A Balazs, B Barlaam, J Breed, RJ Carbajo, ... Journal of medicinal chemistry 63 (23), 14530-14559, 2020 | 84 | 2020 |
| Predicting drug pharmacokinetics in humans from in vitro metabolism studies DF McGinnity, RJ Riley Biochemical Society Transactions 29 (2), 135-139, 2001 | 80 | 2001 |
| Rapid characterization of the major drug-metabolizing human hepatic cytochrome P-450 enzymes expressed in Escherichia coli DF McGinnity, SJ Griffin, GC Moody, M Voice, S Hanlon, T Friedberg, ... Drug metabolism and disposition 27 (9), 1017-1023, 1999 | 74 | 1999 |
| Mass spectrometry imaging in oncology drug discovery RJA Goodwin, J Bunch, DF McGinnity Advances in cancer research 134, 133-171, 2017 | 70 | 2017 |
| Prediction of CYP2C9-mediated drug-drug interactions: a comparison using data from recombinant enzymes and human hepatocytes DF McGinnity, J Tucker, S Trigg, RJ Riley Drug Metabolism and Disposition 33 (11), 1700-1707, 2005 | 60 | 2005 |
| Integrated in vitro analysis for the in vivo prediction of cytochrome P450-mediated drug-drug interactions DF McGinnity, NJ Waters, J Tucker, RJ Riley Drug metabolism and disposition 36 (6), 1126-1134, 2008 | 54 | 2008 |
