Inferring protein 3D structure from deep mutation scans NJ Rollins, KP Brock, FJ Poelwijk, MA Stiffler, NP Gauthier, C Sander, ... Nature genetics 51 (7), 1170-1176, 2019 | 152 | 2019 |
Multiplexed measurement of variant abundance and activity reveals VKOR topology, active site and human variant impact MA Chiasson, NJ Rollins, JJ Stephany, KA Sitko, KA Matreyek, M Verby, ... elife 9, e58026, 2020 | 62 | 2020 |
Learning from prepandemic data to forecast viral escape NN Thadani, S Gurev, P Notin, N Youssef, NJ Rollins, D Ritter, C Sander, ... Nature, 1-8, 2023 | 42* | 2023 |
PDBe-KB: collaboratively defining the biological context of structural data Nucleic acids research 50 (D1), D534-D542, 2022 | 32 | 2022 |
Exploring targeting peptide-shell interactions in encapsulin nanocompartments WJ Altenburg, N Rollins, PA Silver, TW Giessen Scientific reports 11 (1), 4951, 2021 | 32 | 2021 |
Chimeric fatty acyl-acyl carrier protein thioesterases provide mechanistic insight into enzyme specificity and expression M Ziesack, N Rollins, A Shah, B Dusel, G Webster, PA Silver, JC Way Applied and environmental microbiology 84 (10), e02868-17, 2018 | 30 | 2018 |
ProteinGym: large-scale benchmarks for protein fitness prediction and design P Notin, A Kollasch, D Ritter, L Van Niekerk, S Paul, H Spinner, N Rollins, ... Advances in Neural Information Processing Systems 36, 2024 | 28* | 2024 |
Natural and designed proteins inspired by extremotolerant organisms can form condensates and attenuate apoptosis in human cells MT Veling, DT Nguyen, NN Thadani, ME Oster, NJ Rollins, KP Brock, ... ACS synthetic biology 11 (3), 1292-1302, 2022 | 13 | 2022 |
Protein design using structure-based residue preferences D Ding, AY Shaw, S Sinai, N Rollins, N Prywes, DF Savage, MT Laub, ... Nature Communications 15 (1), 1639, 2024 | 12* | 2024 |
MaveDB v2: a curated community database with over three million variant effects from multiplexed functional assays A Rubin, J Min, N Rollins, E Da, D Esposito, M Harrington, J Stone, ... bioRxiv, 2021 | 11 | 2021 |
Machine learning for functional protein design P Notin, N Rollins, Y Gal, C Sander, D Marks Nature Biotechnology 42 (2), 216-228, 2024 | 10 | 2024 |
3D protein structure from genetic epistasis experiments NJ Rollins, KP Brock, FJ Poelwijk, MA Stiffler, NP Gauthier, C Sander, ... bioRxiv, 320721, 2018 | 8 | 2018 |
High-Content Screening and Computational Prediction Reveal Viral Genes That Suppress the Innate Immune Response TL Ng, EJ Olson, TY Yoo, HS Weiss, Y Koide, PD Koch, NJ Rollins, ... Msystems 7 (2), e01466-21, 2022 | 4 | 2022 |
Removing bias in sequence models of protein fitness A Shaw, H Spinner, S Gurev, JE Shin, N Rollins, D Marks bioRxiv, 2023 | 3 | 2023 |
Mammalian Cells Engineered To Produce New Steroids ES Spady, TP Wyche, NJ Rollins, J Clardy, JC Way, PA Silver ChemBioChem 19 (17), 1827-1833, 2018 | 2 | 2018 |
High-content screening of coronavirus genes for innate immune suppression reveals enhanced potency of SARS-CoV-2 proteins EJ Olson, DM Brown, TZ Chang, L Ding, TL Ng, HS Weiss, Y Koide, ... bioRxiv, 2021.03. 02.433434, 2021 | 1 | 2021 |
Fc fusion molecules and uses thereof N Higginson-Scott, N Rollins, J Anderson, Y Zhou, A Pellerin, ... US Patent App. 18/512,556, 2024 | | 2024 |
Preclinical Pharmacology of S-1117, a Novel Engineered Fc-fused IgG Cleaving Enzyme, for Chronic Treatment of Autoantibody-mediated Diseases (P4-14.018) I Mascanfroni, J Manasson, A Pellerin, L Sanmarco, J Anderson, N Rollins, ... Neurology 102 (17_supplement_1), 6869, 2024 | | 2024 |
The promise of machine learning: using Seismic’s IMPACT platform to design IgG cleaving enzymes for chronic treatment of autoimmune diseases A Pellerin, J Anderson, N Rollins, L Sanmarco, A Newton, N Le, J Shin, ... The Journal of Immunology 210 (1_Supplement), 85.13-85.13, 2023 | | 2023 |
In vitro assay development to assess successful removal of T and B cell epitopes through Seismic’s IMPACT platform AP Newton, A Pellerin, J Anderson, N Rollins, M Hollfelder, R Peckner, ... The Journal of Immunology 210 (1_Supplement), 85.16-85.16, 2023 | | 2023 |