Zika virus replicons for drug discovery X Xie, J Zou, C Shan, Y Yang, DB Kum, K Dallmeier, J Neyts, PY Shi EBioMedicine 12, 156-160, 2016 | 96 | 2016 |
A single-dose live-attenuated Zika virus vaccine with controlled infection rounds that protects against vertical transmission X Xie, DB Kum, H Xia, H Luo, C Shan, J Zou, AE Muruato, DBA Medeiros, ... Cell host & microbe 24 (4), 487-499. e5, 2018 | 55 | 2018 |
A yellow fever–Zika chimeric virus vaccine candidate protects against Zika infection and congenital malformations in mice DB Kum, N Mishra, R Boudewijns, I Gladwyn-Ng, C Alfano, J Ma, ... npj Vaccines 3 (1), 56, 2018 | 48 | 2018 |
Capsid assembly modulators as antiviral agents against HBV: molecular mechanisms and clinical perspectives V Taverniti, G Ligat, Y Debing, DB Kum, TF Baumert, ER Verrier Journal of clinical medicine 11 (5), 1349, 2022 | 45 | 2022 |
A chimeric yellow fever-Zika virus vaccine candidate fully protects against yellow fever virus infection in mice DB Kum, R Boudewijns, J Ma, N Mishra, D Schols, J Neyts, K Dallmeier Emerging microbes & infections 9 (1), 520-533, 2020 | 23 | 2020 |
Limited evolution of the yellow fever virus 17d in a mouse infection model DB Kum, N Mishra, B Vrancken, HJ Thibaut, A Wilder-Smith, P Lemey, ... Emerging microbes & infections 8 (1), 1734-1746, 2019 | 19 | 2019 |
A high-throughput yellow fever neutralization assay M Rasulova, T Vercruysse, J Paulissen, C Coun, V Suin, L Heyndrickx, ... Microbiology Spectrum 10 (3), e02548-21, 2022 | 12 | 2022 |
Class a capsid assembly modulator RG7907 clears HBV-infected hepatocytes through core-dependent hepatocyte death and proliferation DB Kum, H Vanrusselt, AA Sanchez, V Taverniti, ER Verrier, TF Baumert, ... Hepatology 78 (4), 1252-1265, 2023 | 10 | 2023 |
Comparing immunogenicity and protective efficacy of the yellow fever 17D vaccine in mice J Ma, R Boudewijns, L Sanchez-Felipe, N Mishra, T Vercruysse, ... Emerging Microbes & Infections 10 (1), 2279-2290, 2021 | 8 | 2021 |
Novel non-HAP class A HBV capsid assembly modulators have distinct in vitro and in vivo profiles H Vanrusselt, DB Kum, V Taverniti, C Liu, A Acosta Sanchez, N Corthout, ... Journal of Virology 97 (10), e00722-23, 2023 | 3 | 2023 |
ALG-005398 is a potent non-HAP class I HBV capsid assembly modulator that strongly reduces HBsAg levels in vivo Y Debing, D Buh Kum, AA Sanchez, H Vanrusselt, C Liu, J Deval, ... Hepatology 74, 502A-503A, 2021 | 3 | 2021 |
Best-In-Class Preclinical Characteristics of Alg-000184, A Prodrug of The Capsid Assembly Modulator Alg-001075 for the Treatment of Chronic Hepatitis B Q Zhang, A Jekle, V Serebryany, M Welch, J Liu, S Vendeville, Y Debing, ... The Liver Meeting Digital Experience™, 2020 | 3 | 2020 |
Capsid assembly modulator ALG-000111 and its prodrug ALG-000286 display excellent in vitro and in vivo antiviral activity Y Debing, DB Kum, C Liu, J Deval, H Vanrusselt, AA Sanchez, Q Zhang, ... Cell 500, 4, 2021 | 2 | 2021 |
Non-HAP class I capsid assembly modulators have distinct profiles and a differentiated mechanism of action Y Debing, H Vanrusselt, D Buh Kum, A Acosta Sanchez, V Taverniti, ... AASLD 2022, 2022 | 1 | 2022 |
CAM-A-dependent HBV core aggregation induces apoptosis through ANXA1 V Taverniti, L Meiss-Heydmann, C Gadenne, H Vanrusselt, DB Kum, ... JHEP Reports, 101134, 2024 | | 2024 |
An in vivo duck hepatitis B virus model recapitulates key aspects of nucleic acid polymer treatment outcomes in chronic hepatitis B patients Y Debing, H Vanrusselt, L Degrauwe, DAS de Oliveira, CK Kariuki, ... Antiviral Research 224, 105835, 2024 | | 2024 |
PRECLINICAL RESISTANCE PROFILE AND ANTIVIRAL ACTIVITY OF THE BESTIN-CLASS CAM-E ALG-001075, THE PARENT COMPOUND OF ALG000184 Y Debing, AA Sanchez, H Vanrusselt, D Kum, L Degrauwe, TI Lin, ... Hepatology 78, S583-S583, 2023 | | 2023 |
CLASS A CAMS INDUCE CELL DEATH THROUGH HBV CORE PROTEIN AGGREGATION AND POTENTIALLY ACTIVATE THE INNATE IMMUNE RESPONSE V Taverniti, H Vanrusselt, D Kum, Y Debing, ER Verrier, TF Baumert HEPATOLOGY 78, S561-S562, 2023 | | 2023 |
HAP Class I Capsid Assembly Modulators Clear Hepatitis B Virus-Infected Hepatocytes Through Core-dependent Hepatocyte Death and Subsequent Proliferation DB Kum, H Vanrusselt, AA Sanchez, V Taverniti, ER Verrier, TF Baumert, ... HEPATOLOGY 76, S313-S314, 2022 | | 2022 |
Chimeric yellow fever ZIKA virus strain K Dallmeier, DB Kum, N Mishra, J Neyts, MA Schmid US Patent 11,351,240, 2022 | | 2022 |