ISG15 conjugation system targets the viral NS1 protein in influenza A virus–infected cells C Zhao, TY Hsiang, RL Kuo, RM Krug Proceedings of the National Academy of Sciences 107 (5), 2253-2258, 2010 | 276 | 2010 |
Reciprocal inhibition between intracellular antiviral signaling and the RNAi machinery in mammalian cells GJ Seo, RP Kincaid, T Phanaksri, JM Burke, JM Pare, JE Cox, TY Hsiang, ... Cell host & microbe 14 (4), 435-445, 2013 | 204 | 2013 |
De novo design of potent and resilient hACE2 decoys to neutralize SARS-CoV-2 TW Linsky, R Vergara, N Codina, JW Nelson, MJ Walker, W Su, ... Science 370 (6521), 1208-1214, 2020 | 191 | 2020 |
Interferon-induced ISG15 conjugation inhibits influenza A virus gene expression and replication in human cells TY Hsiang, C Zhao, RM Krug Journal of virology 83 (12), 5971-5977, 2009 | 155 | 2009 |
Interferon-induced ISG15 pathway: an ongoing virus–host battle C Zhao, MN Collins, TY Hsiang, RM Krug Trends in microbiology 21 (4), 181-186, 2013 | 138 | 2013 |
SARS-CoV-2 infects human pluripotent stem cell-derived cardiomyocytes, impairing electrical and mechanical function S Marchiano, TY Hsiang, A Khanna, T Higashi, LS Whitmore, J Bargehr, ... Stem cell reports 16 (3), 478-492, 2021 | 97 | 2021 |
SARS-CoV-2 ORF6 disrupts bidirectional nucleocytoplasmic transport through interactions with Rae1 and Nup98 A Addetia, NAP Lieberman, Q Phung, TY Hsiang, H Xie, P Roychoudhury, ... MBio 12 (2), 10.1128/mbio. 00065-21, 2021 | 93 | 2021 |
Multivalent designed proteins neutralize SARS-CoV-2 variants of concern and confer protection against infection in mice AC Hunt, JB Case, YJ Park, L Cao, K Wu, AC Walls, Z Liu, JE Bowen, ... Science translational medicine 14 (646), eabn1252, 2022 | 76 | 2022 |
Roles of the phosphorylation of specific serines and threonines in the NS1 protein of human influenza A viruses TY Hsiang, L Zhou, RM Krug Journal of virology 86 (19), 10370-10376, 2012 | 66 | 2012 |
Regulation of retinoic acid inducible gene-I (RIG-I) activation by the histone deacetylase 6 HM Liu, F Jiang, YM Loo, SZ Hsu, TY Hsiang, J Marcotrigiano, M Gale EBioMedicine 9, 195-206, 2016 | 65 | 2016 |
Endomembrane targeting of human OAS1 p46 augments antiviral activity FW Soveg, J Schwerk, NS Gokhale, K Cerosaletti, JR Smith, ... Elife 10, e71047, 2021 | 51 | 2021 |
Replicating RNA platform enables rapid response to the SARS-CoV-2 Omicron variant and elicits enhanced protection in naïve hamsters compared to ancestral vaccine DW Hawman, K Meade-White, C Clancy, J Archer, T Hinkley, ... EBioMedicine 83, 2022 | 38 | 2022 |
Characterizing viral infection by electron microscopy: lessons from the coronavirus disease 2019 pandemic S Akilesh, RF Nicosia, CE Alpers, M Tretiakova, TY Hsiang, M Gale Jr, ... The American journal of pathology 191 (2), 222-227, 2021 | 36 | 2021 |
T cell receptor sequencing identifies prior SARS-CoV-2 infection and correlates with neutralizing antibodies and disease severity R Elyanow, TM Snyder, SC Dalai, RM Gittelman, J Boonyaratanakornkit, ... JCI insight 7 (10), 2022 | 32 | 2022 |
Cross-validation of SARS-CoV-2 responses in kidney organoids and clinical populations L Helms, S Marchiano, IB Stanaway, TY Hsiang, BA Juliar, S Saini, ... JCI insight 6 (24), 2021 | 31 | 2021 |
SARS-CoV-2 serologic assays in control and unknown populations demonstrate the necessity of virus neutralization testing JA Rathe, EA Hemann, J Eggenberger, Z Li, ML Knoll, C Stokes, ... The Journal of infectious diseases 223 (7), 1120-1131, 2021 | 25 | 2021 |
SARS-CoV2 variant-specific replicating RNA vaccines protect from disease following challenge with heterologous variants of concern DW Hawman, K Meade-White, J Archer, SS Leventhal, D Wilson, C Shaia, ... Elife 11, e75537, 2022 | 23 | 2022 |
Combinations of host-and virus-targeting antiviral drugs confer synergistic suppression of SARS-CoV-2 J Wagoner, S Herring, TY Hsiang, A Ianevski, SB Biering, S Xu, ... Microbiology spectrum 10 (5), e03331-22, 2022 | 21 | 2022 |
Multivalent designed proteins protect against SARS-CoV-2 variants of concern AC Hunt, JB Case, YJ Park, L Cao, K Wu, AC Walls, Z Liu, JE Bowen, ... BioRxiv, 2021 | 16 | 2021 |
Discovery of GS-5245 (obeldesivir), an oral prodrug of nucleoside GS-441524 that exhibits antiviral efficacy in SARS-CoV-2-infected African green monkeys RL Mackman, RV Kalla, D Babusis, J Pitts, KT Barrett, K Chun, V Du Pont, ... Journal of Medicinal Chemistry 66 (17), 11701-11717, 2023 | 14 | 2023 |