| TREM2 regulates microglial cholesterol metabolism upon chronic phagocytic challenge AA Nugent, K Lin, B Van Lengerich, S Lianoglou, L Przybyla, SS Davis, ... Neuron 105 (5), 837-854. e9, 2020 | 440 | 2020 |
| Presenilin-1 knockin mice reveal loss-of-function mechanism for familial Alzheimer’s disease D Xia, H Watanabe, B Wu, SH Lee, Y Li, E Tsvetkov, VY Bolshakov, ... Neuron 85 (5), 967-981, 2015 | 262 | 2015 |
| Enhancing protective microglial activities with a dual function TREM 2 antibody to the stalk region K Schlepckow, KM Monroe, G Kleinberger, L Cantuti‐Castelvetri, ... EMBO molecular medicine 12 (4), e11227, 2020 | 190 | 2020 |
| A TREM2-activating antibody with a blood–brain barrier transport vehicle enhances microglial metabolism in Alzheimer’s disease models B van Lengerich, L Zhan, D Xia, D Chan, D Joy, JI Park, D Tatarakis, ... Nature neuroscience 26 (3), 416-429, 2023 | 82 | 2023 |
| Novel App knock-in mouse model shows key features of amyloid pathology and reveals profound metabolic dysregulation of microglia D Xia, S Lianoglou, T Sandmann, M Calvert, JH Suh, E Thomsen, ... Molecular neurodegeneration 17 (1), 41, 2022 | 41 | 2022 |
| Loss of Aβ43 production caused by presenilin-1 mutations in the knockin mouse brain D Xia, RJ Kelleher, J Shen Neuron 90 (2), 417-422, 2016 | 40 | 2016 |
| The Flightless I Homolog, fli-1, Regulates Anterior/Posterior Polarity, Asymmetric Cell Division and Ovulation During Caenorhabditis elegans Development H Deng, D Xia, B Fang, H Zhang Genetics 177 (2), 847-860, 2007 | 39 | 2007 |
| The C. elegans CBFβ homolog, BRO-1, regulates the proliferation, differentiation and specification of the stem cell-like seam cell lineages D Xia, Y Zhang, X Huang, Y Sun, H Zhang Developmental biology 309 (2), 259-272, 2007 | 36 | 2007 |
| Familial frontotemporal dementia-associated presenilin-1 c. 548G> T mutation causes decreased mRNA expression and reduced presenilin function in knock-in mice H Watanabe, D Xia, T Kanekiyo, RJ Kelleher, J Shen Journal of Neuroscience 32 (15), 5085-5096, 2012 | 26 | 2012 |
| Fibrillar Aβ causes profound microglial metabolic perturbations in a novel APP knock-in mouse model D Xia, S Lianoglou, T Sandmann, M Calvert, JH Suh, E Thomsen, ... bioRxiv, 2021.01. 19.426731, 2021 | 8 | 2021 |
| The temporally regulated transcription factor sel-7 controls developmental timing in C. elegans D Xia, X Huang, H Zhang Developmental biology 332 (2), 246-257, 2009 | 7 | 2009 |
| Quantitative Bioimaging of Microglial Response to Brain-Targeted Treatment Using Deep Learning Based Morphometry D Joy, D Xia, K Monroe, P Sanchez, M Calvert Microscopy and Microanalysis 28 (S1), 1422-1423, 2022 | | 2022 |
