Strategy and success for the directed evolution of enzymes PA Dalby Current opinion in structural biology 21 (4), 473-480, 2011 | 263 | 2011 |
Optimising enzyme function by directed evolution PA Dalby Current opinion in structural biology 13 (4), 500-505, 2003 | 195 | 2003 |
Accelerated design of bioconversion processes using automated microscale processing techniques GJ Lye, P Ayazi-Shamlou, F Baganz, PA Dalby, JM Woodley TRENDS in Biotechnology 21 (1), 29-37, 2003 | 187 | 2003 |
One‐pot synthesis of amino‐alcohols using a de‐novo transketolase and β‐alanine: Pyruvate transaminase pathway in Escherichia coli CU Ingram, M Bommer, MEB Smith, PA Dalby, JM Ward, HC Hailes, ... Biotechnology and bioengineering 96 (3), 559-569, 2007 | 183 | 2007 |
Two strategies to engineer flexible loops for improved enzyme thermostability H Yu, Y Yan, C Zhang, PA Dalby Scientific reports 7 (1), 41212, 2017 | 178 | 2017 |
Directed evolution of biocatalytic processes EG Hibbert, F Baganz, HC Hailes, JM Ward, GJ Lye, JM Woodley, ... Biomolecular engineering 22 (1-3), 11-19, 2005 | 154 | 2005 |
Directed evolution strategies for improved enzymatic performance EG Hibbert, PA Dalby Microbial Cell Factories 4, 1-6, 2005 | 127 | 2005 |
A multidisciplinary approach toward the rapid and preparative-scale biocatalytic synthesis of chiral amino alcohols: a concise transketolase-/ω-transaminase-mediated synthesis … MEB Smith, BH Chen, EG Hibbert, U Kaulmann, K Smithies, JL Galman, ... Organic Process Research & Development 14 (1), 99-107, 2010 | 109 | 2010 |
Directed evolution of transketolase activity on non-phosphorylated substrates EG Hibbert, T Senussi, SJ Costelloe, W Lei, MEB Smith, JM Ward, ... Journal of biotechnology 131 (4), 425-432, 2007 | 109 | 2007 |
Evolutionary analysis of the TPP-dependent enzyme family SJ Costelloe, JM Ward, PA Dalby Journal of molecular evolution 66, 36-49, 2008 | 99 | 2008 |
Directed evolution of transketolase substrate specificity towards an aliphatic aldehyde EG Hibbert, T Senussi, MEB Smith, SJ Costelloe, JM Ward, HC Hailes, ... Journal of biotechnology 134 (3-4), 240-245, 2008 | 97 | 2008 |
Non-α-hydroxylated aldehydes with evolved transketolase enzymes A Cázares, JL Galman, LG Crago, MEB Smith, J Strafford, L Ríos-Solís, ... Organic & biomolecular chemistry 8 (6), 1301-1309, 2010 | 90 | 2010 |
Enhancing and Reversing the Stereoselectivity of Escherichia coli Transketolase via Single‐Point Mutations MEB Smith, EG Hibbert, AB Jones, PA Dalby, HC Hailes Advanced Synthesis & Catalysis 350 (16), 2631-2638, 2008 | 90 | 2008 |
The global landscape of approved antibody therapies X Lyu, Q Zhao, J Hui, T Wang, M Lin, K Wang, J Zhang, J Shentu, ... Antibody therapeutics 5 (4), 233-257, 2022 | 89 | 2022 |
Coupled molecular dynamics mediate long-and short-range epistasis between mutations that affect stability and aggregation kinetics H Yu, PA Dalby Proceedings of the National Academy of Sciences 115 (47), E11043-E11052, 2018 | 84 | 2018 |
Engineering enzymes for biocatalysis PA Dalby Recent patents on biotechnology 1 (1), 1-9, 2007 | 82 | 2007 |
Exploiting correlated molecular-dynamics networks to counteract enzyme activity–stability trade-off H Yu, PA Dalby Proceedings of the National Academy of Sciences 115 (52), E12192-E12200, 2018 | 81 | 2018 |
High‐throughput measurement of protein stability in microtiter plates JP Aucamp, AM Cosme, GJ Lye, PA Dalby Biotechnology and Bioengineering 89 (5), 599-607, 2005 | 80 | 2005 |
Mapping the aggregation kinetics of a therapeutic antibody fragment N Chakroun, D Hilton, SS Ahmad, GW Platt, PA Dalby Molecular pharmaceutics 13 (2), 307-319, 2016 | 76 | 2016 |
Identification and use of an alkane transporter plug-in for applications in biocatalysis and whole-cell biosensing of alkanes C Grant, D Deszcz, YC Wei, RJ MartInez-Torres, P Morris, T Folliard, ... Scientific reports 4 (1), 5844, 2014 | 73 | 2014 |