| Structure of an IκBα/NF-κB complex MD Jacobs, SC Harrison Cell 95 (6), 749-758, 1998 | 1178 | 1998 |
| The structure of dimeric ROCK I reveals the mechanism for ligand selectivity M Jacobs, K Hayakawa, L Swenson, S Bellon, M Fleming, P Taslimi, ... Journal of Biological Chemistry 281 (1), 260-268, 2006 | 347 | 2006 |
| Pim-1 ligand-bound structures reveal the mechanism of serine/threonine kinase inhibition by LY294002 MD Jacobs, J Black, O Futer, L Swenson, B Hare, M Fleming, K Saxena Journal of Biological Chemistry 280 (14), 13728-13734, 2005 | 230 | 2005 |
| Discovery of a novel, first-in-class, orally bioavailable azaindole inhibitor (VX-787) of influenza PB2 MP Clark, MW Ledeboer, I Davies, RA Byrn, SM Jones, E Perola, A Tsai, ... Journal of medicinal chemistry 57 (15), 6668-6678, 2014 | 222 | 2014 |
| Comparison of dabigatran and warfarin in patients with atrial fibrillation and valvular heart disease: the RE-LY Trial (Randomized Evaluation of Long-Term Anticoagulant Therapy) MD Ezekowitz, R Nagarakanti, H Noack, M Brueckmann, C Litherland, ... Circulation 134 (8), 589-598, 2016 | 199 | 2016 |
| Preclinical activity of VX-787, a first-in-class, orally bioavailable inhibitor of the influenza virus polymerase PB2 subunit RA Byrn, SM Jones, HB Bennett, C Bral, MP Clark, MD Jacobs, AD Kwong, ... Antimicrobial agents and chemotherapy 59 (3), 1569-1582, 2015 | 199 | 2015 |
| Structure-guided design of potent and selective pyrimidylpyrrole inhibitors of extracellular signal-regulated kinase (ERK) using conformational control AM Aronov, Q Tang, G Martinez-Botella, GW Bemis, J Cao, G Chen, ... Journal of medicinal chemistry 52 (20), 6362-6368, 2009 | 186 | 2009 |
| Docking study yields four novel inhibitors of the protooncogene Pim-1 kinase AC Pierce, M Jacobs, C Stuver-Moody Journal of medicinal chemistry 51 (6), 1972-1975, 2008 | 140 | 2008 |
| Flipped out: structure-guided design of selective pyrazolylpyrrole ERK inhibitors AM Aronov, C Baker, GW Bemis, J Cao, G Chen, PJ Ford, UA Germann, ... Journal of medicinal chemistry 50 (6), 1280-1287, 2007 | 138 | 2007 |
| Staphylococcal nuclease folding intermediate characterized by hydrogen exchange and NMR spectroscopy. MD Jacobs, RO Fox PNAS 91 (2), 449-453, 1994 | 131 | 1994 |
| Classifying protein kinase structures guides use of ligand‐selectivity profiles to predict inactive conformations: Structure of lck/imatinib complex MD Jacobs, PR Caron, BJ Hare Proteins: Structure, Function, and Bioinformatics 70 (4), 1451-1460, 2008 | 89 | 2008 |
| Structure-based design of 3-aryl-6-amino-triazolo[4,3-b]pyridazine inhibitors of Pim-1 kinase R Grey, AC Pierce, GW Bemis, MD Jacobs, CS Moody, R Jajoo, N Mohal, ... Bioorganic & medicinal chemistry letters 19 (11), 3019-3022, 2009 | 77 | 2009 |
| Second-generation antibacterial benzimidazole ureas: discovery of a preclinical candidate with reduced metabolic liability AL Grillot, AL Tiran, D Shannon, E Krueger, Y Liao, H O’Dowd, Q Tang, ... Journal of Medicinal Chemistry 57 (21), 8792-8816, 2014 | 71 | 2014 |
| Applications of SHAPES screening in drug discovery CA Lepre, J Peng, J Fejzo, N Abdul-Manan, J Pocas, M Jacobs, X Xie, ... Combinatorial Chemistry & High Throughput Screening 5 (8), 583-590, 2002 | 71 | 2002 |
| Crystal structure of human JAK3 kinase domain complex and binding pockets thereof H Zuccola, M Jacobs, L Swenson, K Saxena US Patent 7,558,717, 2009 | 62 | 2009 |
| Court MP Clark, MW Ledeboer, I Davies, RA Byrn, SM Jones, E Perola, A Tsai, ... JJ, Deng, H., Duffy, JP, Dorsch, WA, Farmer, LJ, Gao, H., Gu, W., Jackson, K …, 2014 | 52 | 2014 |
| Novel 2-substituted 7-azaindole and 7-azaindazole analogues as potential antiviral agents for the treatment of influenza UK Bandarage, MP Clark, E Perola, H Gao, MD Jacobs, A Tsai, ... ACS medicinal chemistry letters 8 (2), 261-265, 2017 | 51 | 2017 |
| Structure-based design and parallel synthesis of N-benzyl isatin oximes as JNK3 MAP kinase inhibitors J Cao, H Gao, G Bemis, F Salituro, M Ledeboer, E Harrington, S Wilke, ... Bioorganic & medicinal chemistry letters 19 (10), 2891-2895, 2009 | 51 | 2009 |
| Design, synthesis, and structure–activity relationships of pyridine-based rho kinase (ROCK) inhibitors J Green, J Cao, UK Bandarage, H Gao, J Court, C Marhefka, M Jacobs, ... Journal of Medicinal Chemistry 58 (12), 5028-5037, 2015 | 43 | 2015 |
| Stress and strain in staphylococcal nuclease A Hodel, RA Kautz, MD Jacobs, RO Fox Protein Science 2 (5), 838-850, 1993 | 42 | 1993 |
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